Prevalencia de tumores metastásicos en la glándula tiroides. Revisión sistemática y metanálisis.

Rodrigo-Gómez, Lucía; Pardal-Refoyo, José Luis; Batuecas‐Caletrío, Ángel

doi:10.14201/orl.23207

Cited by 2 publications

References 119 publications

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Thyroid gland: a rare site of metastasis

Orlandi,

Alcaraz,

Bielski

et al. 2024

Endocrine

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Purpose: Despite its rich vascularity, metastasis (MTS) to the thyroid tissue is unusual, ranging from 1 to 3%. This entity is not usually considered as differential diagnosis and is not included in the upfront approach in patients with thyroid nodules. Once diagnosed, treatment is controversial. The aim of this study was to evaluate diagnosis, treatment and outcome at the end of follow-up in patients with a diagnosis of MTS to the thyroid.Methods: A retrospective multicenter study was designed from 1985 to 2022; 29 patients with MTS to the thyroid gland were included in the analysis.Results: Clinical presentation included the presence of a thyroid nodule (65.5%), compression symptoms (17.2%), diffuse goiter (10.3%), and suspicious lymph nodes in the neck (7%). Primary tumor sites were: kidney (44.8%), breast (24.1%), lung (13.8%), neuroendocrine system (6.9%), colon (3.4%), cervix (3.4%), and ovary (3.4%). In 18/23 patients, suspicious ultrasound criteria for malignancy were described.Preoperative diagnosis was made in 23/27 patients by FNA, and con rmed in 18 cases by immunohistochemistry. Seventeen patients underwent surgery. At the end of follow-up, 19 patients had died of oncological disease, and 6 were alive (2/6 disease-free with isolated intra-thyroidal MTS).Conclusion: Renal carcinoma was the tumor that most frequently metastasized to the thyroid gland.Immunodiagnosis was a very useful tool for etiological con rmation. Patients with MTS to the thyroid gland as a unique site had a more favorable course compared to patients with multiple metastatic sites.Finally, outcomes and prognosis essentially depended on the biology of the primary tumor.

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Thyroid gland: a rare site of metastasis

Orlandi,

Alcaraz,

Bielski

et al. 2024

Endocrine

View full text Add to dashboard Cite

show abstract

Thyroid gland: A rare site of metastasis

Orlandi,

Alcaraz,

Bielski

et al. 2023

Preprint

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Purpose: Despite its rich vascularity, metastasis (MTS) to the thyroid tissue is unusual, ranging from 1 to 3%. This entity is not usually considered as differential diagnosis and is not included in the upfront approach in patients with thyroid nodules. Once diagnosed, treatment is controversial. The aim of this study was to evaluate diagnosis, treatment and outcome at the end of follow-up in patients with a diagnosis of MTS to the thyroid. Methods: A retrospective multicenter study was designed from 1985 to 2022; 29 patients with MTS to the thyroid gland were included in the analysis. Results: Clinical presentation included the presence of a thyroid nodule (65.5%), compression symptoms (17.2%), diffuse goiter (10.3%), and suspicious lymph nodes in the neck (7%). Primary tumor sites were: kidney (44.8%), breast (24.1%), lung (13.8%), neuroendocrine system (6.9%), colon (3.4%), cervix (3.4%), and ovary (3.4%). In 18/23 patients, suspicious ultrasound criteria for malignancy were described. Preoperative diagnosis was made in 23/27 patients by FNA, and confirmed in 18 cases by immunohistochemistry. Seventeen patients underwent surgery. At the end of follow-up, 19 patients had died of oncological disease, and 6 were alive (2/6 disease-free with isolated intra-thyroidal MTS). Conclusion: Renal carcinoma was the tumor that most frequently metastasized to the thyroid gland. Immunodiagnosis was a very useful tool for etiological confirmation. Patients with MTS to the thyroid gland as a unique site had a more favorable course compared to patients with multiple metastatic sites. Finally, outcomes and prognosis essentially depended on the biology of the primary tumor.

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Prevalencia de tumores metastásicos en la glándula tiroides. Revisión sistemática y metanálisis.

Cited by 2 publications

References 119 publications

Thyroid gland: a rare site of metastasis

Thyroid gland: a rare site of metastasis

Thyroid gland: A rare site of metastasis

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