Prevalência de soropositividade para toxoplasmose em gestantes

Varella, Ivana Rosângela dos Santos; Wagner, Mário Bernardes; Darela, Alessandra C.; Nunes, Leandro Meirelles; Müller, R

doi:10.1590/s0021-75572003000100012

Cited by 36 publications

(49 citation statements)

References 29 publications

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“…The high prevalence of acute toxoplasmosis during pregnancy found in this study was expected, since a high frequency of seropositivity (prevalence: 59.8%; 95% CI: 57.0-62.5%) in this population was reported in a previous study (Varella et al 2003).…”

Section: Discussionsupporting

confidence: 79%

Prevalence of acute toxoplasmosis infection among 41,112 pregnant women and the mother-to-child transmission rate in a public hospital in South Brazil

Varella

Canti

Santos

et al. 2009

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 79%

Prevalence of acute toxoplasmosis infection among 41,112 pregnant women and the mother-to-child transmission rate in a public hospital in South Brazil

Varella

Canti

Santos

et al. 2009

Mem. Inst. Oswaldo Cruz

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“…In Porto Alegre, three studies involving large populations of pregnant women showed prevalences of toxoplasmic infection between 54.3% and 61.1%, similar to the highest described internationally (Neves et al1994, Varella et al 2003, Reis 2006. The results indirectly show that pregnant women who have not yet been infected are highly vulnerable to primary infection.…”

supporting

confidence: 55%

Contributions to the history of ocular toxoplasmosis in Southern Brazil

Melamed

2009

Mem. Inst. Oswaldo Cruz

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“…No Brasil, estudos realizados com grávidas evidenciaram 67% de positividade em Londrina-PR 37 , e outras regiões de mesmo padrão social, também mostraram prevalência equivalente, como 59,8% em Porto Alegre-RS 44 , 51,6% em Uberlândia-MG 16 e 71,4% em São Bernardo do Campo-SP 16 .…”

Section: Discussionunclassified

Evidência sorológica da infecção aguda pelo Toxoplasma gondii em gestantes de Cascavel, Paraná

Mioranza

Meireles

Mioranza³

et al. 2008

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 41(6):628-634, nov-dez, 2008 ARTIGO/ARTICLEA toxoplasmose, infecção causada pelo parasita Toxoplasma gondii 11 15 , é especialmente importante na infecção congênita e reativação em imunodeprimidos 26 , sendo geralmente assintomática ou associada a manifestações inespecíficas em indivíduos imunocompetentes 30 .A primo-infecção na gravidez pode afetar o feto, com severas complicações, como nascimento prematuro, dano neurológico permanente e comprometimento visual 20 31 . A freqüência e severidade da infecção congênita dependem do período gestacional 12 e do diagnóstico precoce para intervenção terapêutica específica 34 e redução do risco de infecção fetal. ABSTRACTIn order to investigate the incidence of toxoplasmosis in Cascavel, Paraná, a city near the region where the largest reported epidemic outbreak in the world occurred, 334 serum samples from pregnant women were screened using a commercial IgG immunoenzymatic assay at the Municipal Laboratory in Cascavel and were confirmed at the Institute of Tropical Medicine in São Paulo, by means of IgG immunofluorescence, immunoenzymatic assaying and the in-house IgG avidity test. The IgG seropositivity from the commercial test was 54.2%, from immunofluorescence 54.8% and from the in-house IgG 53.9%, with good agreement between immunofluorescence and the commercial IgG test (kappa = 0.963781; co-positivity = 97.8%; co-negativity = 98,7%) and between immunofluorescence and the in-house IgG (kappa = 0.975857; co-positivity = 97.8%; co-negativity = 100%). The evidence of acute infection among the pregnant women was similar, as estimated both by IgG avidity (2.4%/year) and by statistical trend analysis (χ 2 test) according to age group (2%/year). This suggests that prenatal serological screening and epidemiological surveillance are essential for reducing the risk of toxoplasmosis in the region, although without evidence of an epidemic outbreak. Key-words: Toxoplasma gondii. Immunodiagnosis. IgG avidity.Para o diagnóstico da infecção pelo Toxoplasma gondii, os testes sorológicos de imunofluorescência indireta, aglutinação e imunoenzimáticos são os métodos mais freqüentemente utilizados para pesquisa de anticorpos específicos como IgM e/ou IgA e/ou aumento significante do nível de anticorpos IgG 2 41 .Contudo, o diagnóstico sorológico da toxoplasmose é muito complexo e tem sido discutido extensivamente na literatura, especialmente em gestantes 31 . Os resultados devem ser interpretados com cautela 46 , porque tanto a IgA 18 quanto a IgM podem persistir por anos, levando a erro na determinação da época da infecção materna 24 e falha no diagnóstico da infecção aguda na gestante 22 .

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Prevalência de soropositividade para toxoplasmose em gestantes

Cited by 36 publications

References 29 publications

Prevalence of acute toxoplasmosis infection among 41,112 pregnant women and the mother-to-child transmission rate in a public hospital in South Brazil

Prevalence of acute toxoplasmosis infection among 41,112 pregnant women and the mother-to-child transmission rate in a public hospital in South Brazil

Contributions to the history of ocular toxoplasmosis in Southern Brazil

Evidência sorológica da infecção aguda pelo Toxoplasma gondii em gestantes de Cascavel, Paraná

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