Prevalencia de la infección por Helicobacter pylori en el linfoma MALT gástrico: una revisión sistemática

Asenjo, L M; Gisbert, Javier P.

doi:10.4321/s1130-01082007000700006

Cited by 47 publications

(18 citation statements)

References 38 publications

(44 reference statements)

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“…Explanations for this diversity may be multiple and seem to depend, at least partly, on the number and type of techniques used to detect the infection, the histological grade of lymphoma, and the depth of tumor invasion. Thus, if appropriate diagnostic methods (in number and characteristics) are used, and if only low-grade lymphomas are considered, the prevalence of H. pylori infection increases to nearly 90%, which reinforces the causal role of these bacteria in gastric MALT lymphoma (8). Nevertheless, in our study, when only low-grade lymphomas in stage EI were considered, H. pylori prevalence was still low (55%).…”

Section: Discussionsupporting

confidence: 64%

“…A higher H. pylori prevalence has been described when serologic rather than histological methods were used (8). This probably could be explained by a decrease in bacterial colonization due to gastric atrophy and hypochlorhydria; however, antibodies against bacteria can be detected even years after mucosal clearance (38,54).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies showed that the prevalence of infection depends on the lymphoma's histological grade or the diagnostic method used, among others (8). A knowledge of the true prevalence of H. pylori in patients with MALT lymphoma is clinically relevant, as the detection of this organism will be followed by adequate eradication treatment, with consequent tumor regression in a high number of cases (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Gisbert

Aguado

Luna

et al. 2006

Rev. esp. enferm. dig.

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Objective: to perform a retrospective review of the clinical characteristics and prevalence of H. pylori infection in patients with gastric MALT lymphoma diagnosed in our hospital during the last 15 years.Methods: patients with gastric MALT lymphoma diagnosed in our hospital during the last 15 years were retrospectively included. Demographic, clinic, analytic, endoscopic, and histological variables were reviewed. The extension study, the staging classification, and the presence of H. pylori infection were assessed.Results: thirty-seven patients with gastric MALT lymphoma were identified. Mean age was 61 years, with 62% of males. The most common presentation symptom was dyspepsia (76%), followed by digestive bleeding (11%) and constitutional syndrome (8%). At endoscopy, erosive lesions were identified in 41%, and proliferative or exophytic lesions in 43%. Most lymphomas were classified as low-grade (68%). The stage distribution was EI for 56%, EII for 13%, EIII for 3%, and EIV for 28%. The prevalence of H. pylori infection (histology in all cases, rapid urease test in 19%, and 13 C-urea breath test in 24%) was 46%. When only lowgrade lymphomas in stage EI were considered, H. pylori prevalence increased to 55%. When H. pylori infection was evaluated by 13 C-urea breath testing (in addition to histology), the prevalence of H. pylori infection increased to 78%.Conclusions: it is probable that the reduced H. pylori prevalence found in some studies, as in ours, could be explained by false-negative results obtained when only one diagnostic method was used. Therefore, at least two (invasive) diagnostic methods should be performed. Furthermore, the performance of a non-invasive diagnostic method (such as a 13 C-urea breath test) before the exclusion of H. pylori infection should be considered.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Gisbert

Aguado

Luna

et al. 2006

Rev. esp. enferm. dig.

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“…Gastric MALT lymphomas usually show slow progression and are localized; therefore, they are clinically characterized by long disease-free and long overall survival periods 14–16. In gastric MALT lymphomas, H. pylori infection is generally known as an important cause of the disease, and when appropriate diagnostic methods are used, the prevalence of H. pylori infection is high, at nearly 90% 16.…”

Section: Discussionmentioning

confidence: 99%

“…In gastric MALT lymphomas, H. pylori infection is generally known as an important cause of the disease, and when appropriate diagnostic methods are used, the prevalence of H. pylori infection is high, at nearly 90% 16. Therefore, eradication therapy against H. pylori is universally accepted as the first-line treatment for H. pylori -positive gastric MALT lymphoma,6,17 achieving complete lymphoma remission in 60% to 90% of patients 3,6,18.…”

Section: Discussionmentioning

confidence: 99%

Treatment Outcome for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according toHelicobacter pyloriInfection Status: A Single-Center Experience

Ryu¹,

Kim²,

Park³

et al. 2014

Gut Liver

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Background/AimsHelicobacter pylori eradication therapy has been used as a first-line treatment for H. pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, the management strategy for H. pylori-negative MALT lymphoma remains controversial. Therefore, the aim of this study was to examine the success rate of each treatment option for H. pylori-positive and H. pylori-negative gastric MALT lymphomas.MethodsIn total, 57 patients with gastric MALT lymphoma diagnosed between December 2000 and June 2012 were enrolled in the study. The treatment responses were compared between H. pylori-positive and H. pylori-negative gastric MALT lymphomas.ResultsOf the 57 patients, 43 (75%) had H. pylori infection. Forty-eight patients received H. pylori eradication as a first-line treatment, and complete remission was achieved in 31 of the 39 patients (80%) with H. pylori-positive MALT lymphoma and in five (56%) of the nine patients with H. pylori-negative MALT lymphoma; no significant difference was observed between the groups (p=0.135). The other treatment modalities, including radiation therapy, chemotherapy, and surgery, were effective irrespective of H. pylori infection status, with no significant difference in the treatment response between H. pylori-positive and H. pylori-negative MALT lymphomas.ConclusionsH. pylori eradication therapy may be considered as a first-line treatment regardless of H. pylori infection status.

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Helicobacter pylori Infection: When Should It Be Treated?

Fong

2020

Current Trends and Concerns in Infectious Diseases

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Prevalencia de la infección por Helicobacter pylori en el linfoma MALT gástrico: una revisión sistemática

Cited by 47 publications

References 38 publications

Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Treatment Outcome for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according toHelicobacter pyloriInfection Status: A Single-Center Experience

Helicobacter pylori Infection: When Should It Be Treated?

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