Prevalencia de insuficiencia renal oculta y variables asociadas en una población de pacientes con diabetes tipo 2

Rodríguez‐Poncelas, Antonio; Sabaté, Miquel Quesada; Coll‐de‐Tuero, Gabriel; Ros, Jacint Caula; Gelada-Batlle, Esther; Gómez‐Marcos, Manuel A.; Garré-Olmo, Josep; Daniel, Carme Comalada; Ramos, Rafael

doi:10.1016/j.medcli.2009.06.069

Cited by 16 publications

(17 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, the European Societies of Cardiology and Hypertension [20] recommend adopting different normal values according to gender (<31 mg/g or 3.5 mg/mmol for men and <22 mg/g or 2.5 mg/mmol for women). So, i is possible that if we had used the European criteria, the prevalence of albuminuria would have been similar to the prevalence obtained by [12] in a similar cohort: 20.6%.…”

Section: Discussionsupporting

confidence: 68%

Chronic kidney disease in the type 2 diabetic patients: prevalence and associated variables in a random sample of 2642 patients of a Mediterranean area

et al. 2012

View full text Add to dashboard Cite

BackgroundKidney disease is associated with an increased total mortality and cardiovascular morbimortality in the general population and in patients with Type 2 diabetes. The aim of this study is to determine the prevalence of kidney disease and different types of renal disease in patients with type 2 diabetes (T2DM).MethodsCross-sectional study in a random sample of 2,642 T2DM patients cared for in primary care during 2007. Studied variables: demographic and clinical characteristics, pharmacological treatments and T2DM complications (diabetic foot, retinopathy, coronary heart disease and stroke). Variables of renal function were defined as follows: 1) Microalbuminuria: albumin excretion rate & 30 mg/g or 3.5 mg/mmol, 2) Macroalbuminuria: albumin excretion rate & 300 mg/g or 35 mg/mmol, 3) Kidney disease (KD): glomerular filtration rate according to Modification of Diet in Renal Disease < 60 ml/min/1.73 m2 and/or the presence of albuminuria, 4) Renal impairment (RI): glomerular filtration rate < 60 ml/min/1.73 m2, 5) Nonalbuminuric RI: glomerular filtration rate < 60 ml/min/1.73 m2 without albuminuria and, 5) Diabetic nephropathy (DN): macroalbuminuria or microalbuminuria plus diabetic retinopathy.ResultsThe prevalence of different types of renal disease in patients was: 34.1% KD, 22.9% RI, 19.5% albuminuria and 16.4% diabetic nephropathy (DN). The prevalence of albuminuria without RI (13.5%) and nonalbuminuric RI (14.7%) was similar. After adjusting per age, BMI, cholesterol, blood pressure and macrovascular disease, RI was significantly associated with the female gender (OR 2.20; CI 95% 1.86–2.59), microvascular disease (OR 2.14; CI 95% 1.8–2.54) and insulin treatment (OR 1.82; CI 95% 1.39–2.38), and inversely associated with HbA1c (OR 0.85 for every 1% increase; CI 95% 0.80–0.91). Albuminuria without RI was inversely associated with the female gender (OR 0.27; CI 95% 0.21–0.35), duration of diabetes (OR 0.94 per year; CI 95% 0.91–0.97) and directly associated with HbA1c (OR 1.19 for every 1% increase; CI 95% 1.09–1.3).ConclusionsOne-third of the sample population in this study has KD. The presence or absence of albuminuria identifies two subgroups with different characteristics related to gender, the duration of diabetes and metabolic status of the patient. It is important to determine both albuminuria and GFR estimation to diagnose KD.

show abstract

Section: Discussionsupporting

confidence: 68%

Chronic kidney disease in the type 2 diabetic patients: prevalence and associated variables in a random sample of 2642 patients of a Mediterranean area

et al. 2012

View full text Add to dashboard Cite

show abstract

“…There were no differences in glomerular filtration rate estimated with the CKD-EPI equation either between evaluation timepoints or between groups the values in all cases being over 85 ml/min/1.73 m 2 and greater than those recorded in other studies [33,37]. Likewise, we observed no differences between the two evaluations in terms of the albumin-creatine index the values being lower in the subjects with Metabolic syndrome, and also lower than the values published for diabetic subjects in our setting [37].…”

Section: Discussioncontrasting

confidence: 48%

“…Likewise, we observed no differences between the two evaluations in terms of the albumin-creatine index the values being lower in the subjects with Metabolic syndrome, and also lower than the values published for diabetic subjects in our setting [37]. …”

Section: Discussioncontrasting

confidence: 46%

Yearly evolution of organ damage markers in diabetes or metabolic syndrome: data from the LOD-DIABETES study

Gómez‐Marcos¹,

Patino-Alonso

Agudo‐Conde³

et al. 2011

Cardiovasc Diabetol

View full text Add to dashboard Cite

BackgroundCardiovascular disease morbidity-mortality is greater in people with type 2 diabetes mellitus or metabolic syndrome. The purpose of this study was to evaluate the yearly evolution of organ damage markers in diabetes or metabolic syndrome, and to analyze the associated factors.MethodsAn observational prospective study was carried out in the primary care setting, involving 112 patients: 68 diabetics and 44 subjects with metabolic syndrome, subjected to 12 months of follow-up. Measurements: traditional cardiovascular risk factors (blood pressure, blood glucose, lipids, smoking, body mass index (BMI) and) and non-traditional risk factors (waist circumference, hsC Reactive Protein and fibrinogen); subclinical vascular (carotid intima-media thickness, pulse wave velocity and ankle/brachial index), cardiac (Cornell voltage-duration product), renal organ damage (creatinine, glomerular filtration and albumin/creatinine index), and antihypertensive and lipid-lowering drugs.ResultsAt baseline, the diabetics presented a mean age of 59.9 years, versus 55.2 years in the subjects with metabolic syndrome (p = 0.03). Diastolic blood pressure, total cholesterol and HDL-cholesterol were lower among the patients with diabetes, while blood glucose and HbA1c, as well as antihypertensive and lipid-lowering drug use, were greater. At evaluation after one year, the diabetics showed a decrease in BMI (-0.39), diastolic blood pressure (-3.59), and an increase in fibrinogen (30.23 mg/dL), ankle/brachial index (0.07) and the number of patients with ankle/brachial index pathologic decreased in 6. In turn, the patients with metabolic syndrome showed an increase in HDL-cholesterol (1-91 mg/dL), fibrinogen (25.54 mg/dL), Cornell voltage-duration product (184.22 mm/ms), ankle/brachial index (0.05) and the use of antihypertensive and lipid-lowering drugs, and a reduction in serum glucose (3.74 mg/dL), HOMA, systolic (-6.76 mmHg), diastolic blood pressure (-3.29 mmHg), and pulse wave velocity (-0.72 m/s). The variable that best predicted a decrease in pulse wave velocity in subjects with metabolic syndrome was seen to be an increase in antihypertensive drug use.ConclusionsThe annual assessment of cardiovascular risk factors and the decrease in pulse wave velocity was more favorable in the patients with metabolic syndrome, probably influenced by the increased percentage of subjects treated with antihypertensive and lipid lowering drugs in this group.

show abstract

“…existiendo una relación hiperbólica abierta entre ambas variables 28 . Estudios en diversos ámbitos asistenciales muestran como la IRO constituye el 26 a 49,3% de todas las IR, siendo mayoritariamente estadios 3 y afectando casi exclusivamente a ancianos y mujeres [6][7][8][9][10][11]13,29 . Los resultados de la serie son coincidentes con los previos: casi un tercio de las IR son una IRO, todas un estadio 3, y casi todas son mujeres y más ancianas que el resto de pacientes con IR.…”

Section: Discussionunclassified

Insuficiencia renal en pacientes cardiológicos: buscar para encontrar

Lorente

Salvadó-Usach

2015

Rev. méd. Chile

View full text Add to dashboard Cite

show abstract

Prevalencia de insuficiencia renal oculta y variables asociadas en una población de pacientes con diabetes tipo 2

Cited by 16 publications

References 25 publications

Chronic kidney disease in the type 2 diabetic patients: prevalence and associated variables in a random sample of 2642 patients of a Mediterranean area

Chronic kidney disease in the type 2 diabetic patients: prevalence and associated variables in a random sample of 2642 patients of a Mediterranean area

Yearly evolution of organ damage markers in diabetes or metabolic syndrome: data from the LOD-DIABETES study

Insuficiencia renal en pacientes cardiológicos: buscar para encontrar

Contact Info

Product

Resources

About