Prevalência de infecções congênitas e perinatais em gestantes HIV positivas da região metropolitana de Belo Horizonte

Maia, Marcelle Marie Martins; Lage, Eura Martins; Moreira, Bárbara; Deus, Elayne Alayne Braga de; Faria, Joanna Gonçalves; Pinto, Jorge; Melo, Victor Hugo

doi:10.1590/so100-720320150005355

Cited by 13 publications

(9 citation statements)

References 20 publications

(17 reference statements)

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“…There was a prevalence of deliveries by elective cesarean section in half of the studied population, and deliveries by emergency cesarean section reached the rate of 81.5% of cesareans. The data found differ from the average of previous research results, where the prevalence was 63.0% in the South region and 72.7% in another study in the Southeast region, respectively (6)(7)(8)(9)(10)(11)(12) . In the perinatal prophylaxis and at the time of delivery, there was a significant increase in prevalence, when compared with the same studies that had an average coverage of perinatal prophylaxis of 41.7% and 54.5%, and prophylaxis at delivery was between 67.0% and 77.3%, respectively (1)(2)(3)(4) .…”

Section: Discussioncontrasting

confidence: 99%

“…Regarding the variables related to the newborn, the result of the prevalence of prematurity did not present a significant difference when compared to other studies, as well as low birth weight (1,(13)(14) . Prematurity is an event influenced by several factors, and there is a consensus in the literature that infectious processes are one of the causes of preterm birth (11)(12) .…”

Section: Discussionmentioning

confidence: 99%

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Delivery and birth indicators of seropositive women for the human immunodeficiency virus

et al. 2018

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Objective: to evaluate delivery and birth indicators of seropositive parturient women for the human immunodeficiency virus. Methods: this is a documentary study held with 92 medical records of seropositive women for the human immunodeficiency virus, with analysis of sociodemographic, obstetric and neonatal variables. The chi-square test was used to verify association between predictor variables and outcome. Results: parturient women received prophylaxis perinatal (77.2%) and delivery (91.3%); 52.2% of them performed seven prenatal consultations. 8.7% of newborns were preterm, 18.5% were underweight, and 92.4% received antiretroviral prophylaxis in the first 24 hours of birth. Conclusion: Vulnerability and the highest risk of illness occur in young adults with low education and socioeconomic status. The coverage indicator of pregnant women needs to improve their indexes, since a little more than half of the women performed seven antenatal consultations, negatively impacting the evolution of pregnancy with a percentage of pregnancy prophylaxis below the desired.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Delivery and birth indicators of seropositive women for the human immunodeficiency virus

et al. 2018

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“…In Brazil, several studies have reported the prevalence rates of HIV, HTLV, CMV, HBV and rubella in general populations of pregnant women [ 12 , 18 , 22 , 23 ]. However, epidemiological information about these agents is still scarce in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of HIV, HTLV, CMV, HBV and rubella virus infections in pregnant adolescents who received care in the city of Belém, Pará, Northern Brazil

Guerra

Siravenha

Laurentino

et al. 2018

BMC Pregnancy Childbirth

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BackgroundPrenatal tests are important for prevention of vertical transmission of various infectious agents. The objective of this study was to describe the prevalence of human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis B virus (HBV), cytomegalovirus (CMV), rubella virus and vaccination coverage against HBV in pregnant adolescents who received care in the city of Belém, Pará, Brazil.MethodsA cross-sectional study was performed with 324 pregnant adolescents from 2009 to 2010. After the interview and blood collection, the patients were screened for antibodies and/or antigens against HIV-1/2, HTLV-1/2, CMV, rubella virus and HBV. The epidemiological variables were demonstrated using descriptive statistics with the G, χ2 and Fisher exact tests.ResultsThe mean age of the participants was 15.8 years, and the majority (65.4%) had less than 6 years of education. The mean age at first intercourse was 14.4 years, and 60.8% reported having a partner aged between 12 and 14 years. The prevalence of HIV infection was 0.3%, and of HTLV infection was 0.6%. Regarding HBV, 0.6% of the participants had acute infection, 9.9% had a previous infection, 16.7% had vaccine immunity and 72.8% were susceptible to infection. The presence of anti-HBs was greater in adolescent between 12 and 14 years old (28.8%) while the anti-HBc was greater in adolescent between 15 and 18 years old (10.3%). Most of the adolescents presented the IgG antibody to CMV (96.3%) and rubella (92.3%). None of the participants had acute rubella infection, and 2.2% had anti-CMV IgM.ConclusionsThis study is the first report of the seroepidemiology of infectious agents in a population of pregnant adolescents in the Northern region of Brazil. Most of the adolescents had low levels of education, were susceptible to HBV infection and had IgG antibodies to CMV and rubella virus. The prevalence of HBV, HIV and HTLV was similar to that reported in other regions of Brazil. However, the presence of these agents in this younger population reinforces the need for good prenatal follow-up and more comprehensive vaccination campaigns against HBV due to the large number of women susceptible to the virus.

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“…The rate of transmission from the pregnant woman to the fetus was 70% to 100% depending on the stage of the disease, significantly higher than other infections 2 . Despite the Ministry of Health's efforts to reduce syphilis, this disease is still associated with other risk factors, such as human immunodeficiency virus (HIV) infection and drug use 22 . The difficulties in reducing the incidence and transmission of this disease may be partially explained by a generally asymptomatic condition and inadequate treatment of the pregnant woman and the partner 11,23 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological profile of 39 cases of microcephaly caused by congenital infections diagnosed in the state of Rio Grande do Sul between 2015-2017

Friedrich

Herber

Terra

et al. 2019

CBR

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Introduction: Microcephaly is a clinical finding that can arise from congenital anomalies or emerge after childbirth. Maternal infections acquired during pregnancy can result in characteristic brain damage in the newborn (NB), which may be visible even in the fetal stage. To describe the epidemiological profile of newborns with reported microcephaly and diagnosed with congenital infections in the state of Rio Grande do Sul between 2015 and 2017. Methods: A cross-sectional study was carried out on data collected from the Public Health Event Registry as well as from medical records. The investigation included serologies for toxoplasmosis and rubella; polymerase chain reaction (PCR) for Zika virus (ZIKV) in the blood and cytomegalovirus in the urine; non-treponemal tests for syphilis; and brain imaging tests. Results: Of the 257 reported cases of microcephaly, 39 were diagnosed with congenital infections. Severe microcephaly was identified in 13 patients (33.3%) and 51.3% of the cases showed alterations in brain imaging tests. In relation to the diagnosis of congenital infections, three patients (7.7%) were diagnosed with ZIKV, nine (23.1%) with cytomegalovirus, nine (23.1%) with toxoplasmosis, and 18 (46.1%) with congenital syphilis. The three cases of ZIKV showed calcification in brain imaging tests, signs of arthrogryposis, excess occipital skin and irritability, characterizing the typical phenotype of ZIKV infection. Conclusions: Most cases of congenital infection had severe neurological lesions, particularly the cases of ZIKV, which can cause neurodevelopmental delays and sequelae in these infants throughout early childhood.

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Prevalência de infecções congênitas e perinatais em gestantes HIV positivas da região metropolitana de Belo Horizonte

Cited by 13 publications

References 20 publications

Delivery and birth indicators of seropositive women for the human immunodeficiency virus

Delivery and birth indicators of seropositive women for the human immunodeficiency virus

Seroprevalence of HIV, HTLV, CMV, HBV and rubella virus infections in pregnant adolescents who received care in the city of Belém, Pará, Northern Brazil

Epidemiological profile of 39 cases of microcephaly caused by congenital infections diagnosed in the state of Rio Grande do Sul between 2015-2017

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