Prevalencia de hipovitaminosis D en una población anciana institucionalizada. Valoración del tratamiento sustitutivo

Larrosa, M.; Gratacós, Jordi; Vaqueiro, Montserrat; Prat, Mercè; Campos, Francesc; Figuls, Marta Roqué i

doi:10.1016/s0025-7753(01)72195-1

Cited by 34 publications

(11 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to the Third National Health and Nutrition Examination Survey, 61% of Caucasian- and 91% of African-Americans are vitamin D deficient (Khazai et al, 2008). Figures similar to these have been cited internationally for all segments of the population (Holick and Chen, 2008; MacFarlane et al, 2004), but they tend to be especially high in the old, the ill, and the institutionalized, with studies reporting prevalence statistics ranging from 65% to 74% in hospital inpatients (Chatfield et al, 2007; Corino et al, 2007; Thomas et al, 1998), to 87% in elderly institutionalized patients (Larrosa et al, 2001) and 86% in institutionalized postmenopausal women (Gaugris et al, 2005). Vitamin D deficiency (VitD-deficiency), defined by serum levels of 25-hydroxyvitamin D 3 (25OHD 3 ) below 50 nmol/L or 20 ng/mL (Grant and Holick, 2005), is associated with rickets in children and osteomalacia in adults, and has recently also been linked to a number of systemic conditions such as secondary hyperparathyroidism (Holick, 2005a; McCarty, 2005), metabolic syndrome (Peterlik and Cross, 2005), hypertension (Li et al, 2002; Wang et al, 2008), obesity (Rajakumar et al, 2008), and diabetes mellitus (Giulietti et al, 2004; Grant, 2006), as well as cardiovascular disease outcomes such as stroke and congestive heart failure (Michos and Melamed, 2008; Vieth and Kimball, 2006).…”

Section: Introductionsupporting

confidence: 57%

Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats

Cekić

Cutler

VanLandingham

et al. 2011

Neurobiology of Aging

View full text Add to dashboard Cite

Administration of the neurosteroid progesterone (PROG) has been shown to be beneficial in a number of brain injury models and in two recent clinical trials. Given widespread vitamin D deficiency and increasing traumatic brain injuries (TBIs) in the elderly, we investigated the interaction of vitamin D deficiency and PROG with cortical contusion injury in aged rats. Vitamin D deficient (VitD-deficient) animals showed elevated inflammatory proteins (TNFα, IL-1β, IL-6, NFκB p65) in the brain even without injury. VitD-deficient rats with TBI, whether given PROG or vehicle, showed increased inflammation and greater open-field behavioral deficits compared to VitD-normal animals. Although PROG was beneficial in injured VitD-normal animals, in VitD-deficient subjects neurosteroid treatment conferred no improvement over vehicle. A supplemental dose of 1,25-dihydroxyvitamin D3 (VDH) given with the first PROG treatment dramatically improved results in VitD-deficient rats, but treatment with VDH alone did not. Our results suggest that VitD-deficiency can increase baseline brain inflammation, exacerbate the effects of TBI, and attenuate the benefits of PROG treatment; these effects may be reversed if the deficiency is corrected.

show abstract

Section: Introductionsupporting

confidence: 57%

Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats

Cekić

Cutler

VanLandingham

et al. 2011

Neurobiology of Aging

View full text Add to dashboard Cite

show abstract

“…This state of calciferol insufficiency is replicated in Spain, with results which we show in table 1 [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] . The interlaboratory variation in the different methodologies used makes a rigorous comparison difficult, but the table illustrates clearly that, in spite of a theoretical climatological ease of vitamin D synthesis in Spain, the levels are similar to, or even lower than those reported for central Europe or Scandinavia, as has been described in earlier works 39 .…”

Section: State Of Vitamin D Insufficiency In Spainmentioning

confidence: 55%

“…Most of Spain is above the 35ºN parallel where the possibility of synthesising vitamin D in winter and spring is low, and because most Spanish people have darker skin which makes the synthesis of vitamin D more difficult 39 . We observed that in Spain, as in the rest of the world, insufficiency, or even true deficiency in vitamin D is already found in children or young people, and persists in adults, postmenopausal women (osteoporotic or not), and in older people who live in their own homes, and that it is even higher if they live in residential homes, with a seasonal variation which barley reaches normal levels after summer-autumn [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] . Although this high prevalence of low levels of vitamin D occurs due to inadequate exposure to sunlight, in older Spanish people lower levels have been described in the summer months due to the high temperatures which occur in the cities of southern Spain such as Murcia or Cordoba at this time of year, which are commonly between 30 and 40° C. The older people avoid being in the sun and prefer to remain indoors where the temperature is more comfortable.…”

Section: State Of Vitamin D Insufficiency In Spainmentioning

confidence: 77%

Deficiencia de vitamina D en España: ¿realidad o mito?

Valverde

Gómez

2014

Rev Osteoporos Metab Miner

View full text Add to dashboard Cite

Vitamin D 3 (colecalciferol) is formed from its precursor 7-dehydrocholesterol in the skin by ultraviolet irradiation. In the liver the vitamin D 3 is hydroxylated to form 25-hydroxyvitamin D 3 , which is metabolised to its active metabolite 1,25-dihydroxyvitamin D 3 preferentially in the kidney. Vitamin D 3 may also be provided in the diet, which is a significant source of supply only in the case of insufficient exposure to sunlight. Blue fish naturally contains large quantities of vitamin D 3 , while other foods contain significant quantities of vitamin D only after being fortified. For fortification, in many countries vitamin D 2 is used (ergocalciferol) obtained from vegetable sources 1 . The presence of the enzyme CYP27B1, which drives the synthesis of dihydroxyvitamin D from its principal substrate, 25-hydroxyvitamin D, and the vitamin D receptor (VDR), distributed almost universally in the cells and tissues of the organism, confers on vitamin D (although it would be increasingly more correct to say the endocrine system of vitamin D) a broad role in health. This is not only in the regulation of calcium and bone metabolism but also in relation to the cardiovascular system, innate or acquired immunomodulation, the regulation of cell growth, etc., such that around 3% of the human genome is regulated by the hormone 1,25(OH) 2 vitamin D 3 1-3 . It is therefore not surprising that basic scientific and clinical interest in vitamin D 4 , as well as interest in the non-specialist press and in the general population 5 , has increased almost exponentially in the last decade. 25-hydroxyvitamin D, marker for the status of vitamin D in the bodyFor some years there has been universal consensus that the measurement of the levels of the metabolite 25-hydroxyvitamin D in the blood is the marker for the status of vitamin D in the body, including the endogenous synthesis due to exposure to sunlight, dietary consumption in foods, supplemented or not, and pharmacological treatments 1,2

show abstract

“…The misperception of vitamin D as a “simple vitamin” can hide the effects of its deficiency, which is a significant and on-going problem that has been termed the “silent epidemic”. Vitamin D deficiency has a number of potential consequences, many of which are still unknown [5], [27].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Vitamin D Receptor Silencing on the Expression of LVSCC-A1C and LVSCC-A1D and the Release of NGF in Cortical Neurons

2011

View full text Add to dashboard Cite

BackgroundRecent studies have suggested that vitamin D can act on cells in the nervous system. Associations between polymorphisms in the vitamin D receptor (VDR), age- dependent cognitive decline, and insufficient serum 25 hydroxyvitamin D3 levels in Alzheimer's patients and elderly people with cognitive decline have been reported. We have previously shown that amyloid β (Aβ) treatment eliminates VDR protein in cortical neurons. These results suggest a potential role for vitamin D and vitamin D-mediated mechanisms in Alzheimer's disease (AD) and neurodegeneration. Vitamin D has been shown to down-regulate the L-type voltage-sensitive calcium channels, LVSCC-A1C and LVSCC-A1D, and up-regulate nerve growth factor (NGF). However, expression of these proteins when VDR is repressed is unknown. The aim of this study is to investigate LVSCC-A1C, LVSCC-A1D expression levels and NGF release in VDR-silenced primary cortical neurons prepared from Sprague-Dawley rat embryos.Methodology/Principal FindingsqRT-PCR and western blots were performed to determine VDR, LVSCC-A1C and -A1D expression levels. NGF and cytotoxicity levels were determined by ELISA. Apoptosis was determined by TUNEL. Our findings illustrate that LVSCC-A1C mRNA and protein levels increased rapidly in cortical neurons when VDR is down-regulated, whereas, LVSCC-A1D mRNA and protein levels did not change and NGF release decreased in response to VDR down-regulation. Although vitamin D regulates LVSCC-A1C through VDR, it may not regulate LVSCC-A1D through VDR.Conclusions/SignificanceOur results indicate that suppression of VDR disrupts LVSCC-A1C and NGF production. In addition, when VDR is suppressed, neurons could be vulnerable to aging and neurodegeneration, and when combined with Aβ toxicity, it is possible to explain some of the events that occur during neurodegeneration.

show abstract

Prevalencia de hipovitaminosis D en una población anciana institucionalizada. Valoración del tratamiento sustitutivo

Cited by 34 publications

References 22 publications

Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats

Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats

Deficiencia de vitamina D en España: ¿realidad o mito?

The Effects of Vitamin D Receptor Silencing on the Expression of LVSCC-A1C and LVSCC-A1D and the Release of NGF in Cortical Neurons

Contact Info

Product

Resources

About