Prevalência de fissuras orais no Estado do Rio Grande do Norte, Brasil, entre 2000 e 2005

Figueirêdo, Cristina Jordão R.; Vasconcelos, W.; Maciel, Shirley Suely Soares Veras; Maciel, Wamberto Vieira; Gondim, Líbia Augusta Maciel; Tassitano, Rafael Miranda

doi:10.1590/s0103-05822011000100005

Cited by 11 publications

(8 citation statements)

References 7 publications

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“…The birth prevalence of NSCLP in Brazil was estimated to be 0.19 in 1000 liveborns during the period from 1975 to 1994 and 0.36 in 1000 liveborns from 1998 to 2002 (Rodrigues et al , ; Wettergren et al , ). A previous study reported a prevalence of 0.49 per 1000 liveborns between 2000 and 2005 in the state of Rio Grande do Norte (Figueirêdo et al , ).…”

Section: Introductionmentioning

confidence: 95%

Genetic and non‐genetic factors that increase the risk of non‐syndromic cleft lip and/or palate development

et al. 2014

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Section: Introductionmentioning

confidence: 95%

Genetic and non‐genetic factors that increase the risk of non‐syndromic cleft lip and/or palate development

et al. 2014

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“…4 In Rio Grande do Norte (RN) state, in the northeastern region, a previous study reported a prevalence of 4.9 per 10,000 live births between 2000 and 2005, remaining within the incidence range of 4.82 to 5.50 per 10,000 live births between the years of 2009 and 2013. 3,4,5 The etiology of CL/P is attributed to genetic susceptibility and to maternal exposure to environmental risk factors, including smoking, alcohol consumption, medications, and vitamin deficiencies during pregnancy. 2 According to some studies, alcohol consumption can inhibit retinoic acid production, increasing the risk of CL/P.…”

Section: Introductionmentioning

confidence: 99%

Risk factors and comorbidities in Brazilian patients with orofacial clefts

et al. 2018

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Considering that environmental risk factors substantially contribute to the etiology of orofacial clefts and that knowledge about the characteristics and comorbidities associated with oral clefts is fundamental to promoting better quality of life, this study aimed to describe the risk factors, main characteristics, and comorbidities of a group of patients with cleft lip and/or cleft palate (CL/P) from Rio Grande do Norte (RN), Brazil. Data were obtained from 173 patients with CL/P using a form from the Brazilian database on Orofacial Clefts. Most patients were male with cleft lip and palate and had a normal size and weight at birth; presented few neonatal intercurrent events; and had anemia and respiratory and cardiovascular diseases as main associated comorbidities. They also required timely surgical rehabilitation and multidisciplinary care to stimulate their neuropsychomotor development. In addition, a high frequency of familial recurrence and of parental consanguinity was evidenced in the studied population, especially for the cleft lip and cleft palate type. Other relevant findings were the considerable maternal exposure to alcohol, infections, smoking, and hypertension, as well as low supplementation with vitamins and minerals and deliberate consumption of analgesics, antibiotics, and antihypertensives during pregnancy. Characterization of the CL/P patient profile is essential for the planning of health services and integration among the health professionals involved in the diagnosis and treatment of these malformations. Our results reinforce the need for additional research to confirm the association between environmental factors and the development of orofacial clefts.

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“…Another study showed the mean prevalence of orofacial clefts in Brazil was 0.36 per 1000 live births from 1998 to 2002 (Rodrigues et al , ). In Rio Grande do Norte (Brazil), a study reported a prevalence of 0.49 cases per 1000 live births between 2000 and 2005 (Figueirêdo et al , ).…”

Section: Introductionmentioning

confidence: 99%

MSX1 gene polymorphisms in non‐syndromic cleft lip and/or palate

Bezerra

et al. 2012

Oral Diseases

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Introduction: The aim of this study was to evaluate the association of AXIN2 gene variants rs 7591 and rs 7224837 with non-syndromic cleft lip and palate. Materials and Methods: Blood samples of 30 subjects with NSCLP and 30 unrelated controls were used for the study. The extracted DNA samples were subjected to Polymerase chain reaction in which amplification of the selected gene segments was done; later these amplified products were subjected to DNA sequencing. Results: This study suggests that the likelihood of Non-syndromic cleft lip and palate is higher in subjects having TT (p<0.001) & AT (p=0.03) genotype for AXIN2 gene variant rs7591 and AG (p=0.01) genotype for AXIN2 gene variant rs7224837.Conclusion: The result suggests that AXIN2 gene variant rs7591 and AXIN2 gene variant rs7224837 can be considered as genetic markers for Non syndromic cleft lip and palate in local population.

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Prevalência de fissuras orais no Estado do Rio Grande do Norte, Brasil, entre 2000 e 2005

Cited by 11 publications

References 7 publications

Genetic and non‐genetic factors that increase the risk of non‐syndromic cleft lip and/or palate development

Genetic and non‐genetic factors that increase the risk of non‐syndromic cleft lip and/or palate development

Risk factors and comorbidities in Brazilian patients with orofacial clefts

MSX1 gene polymorphisms in non‐syndromic cleft lip and/or palate

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