Prevalencia de Candida orthopsilosis y Candida metapsilosis en muestras clínicas

Sena, Gabriel; Aznar, P; García-Agudo, Lidia; García-Martos, Pedro

doi:10.1016/j.eimc.2014.06.008

Cited by 1 publication

(2 citation statements)

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“…129). Although CPC may be found as colonizers of skin and mucous membranes [ 15 ], isolates from non-bloodstream sources should receive attention, as they are prone to cause invasive disease in high-risk patients [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…C. parapsilosis sensu stricto and, possibly, C. orthopsilosis and C. metapsilosis , are commensal microorganisms of the human microbiota [ 15 ], but may act as opportunistic pathogens causing systemic infections in immunocompromised patients [ 16 , 17 ]. Accordingly, C. parapsilosis sensu stricto is frequently isolated from the hands, which makes it relevant in the context of hospital-related infections [ 2 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical, Epidemiological and Laboratory Features of Invasive Candida parapsilosis Complex Infections in a Brazilian Pediatric Reference Hospital during the COVID-19 Pandemic

Peixoto

Silva

Portela

et al. 2023

JoF

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The present study aimed to describe the clinical, epidemiological and laboratory characteristics of invasive candidiasis by C. parapsilosis complex (CPC) in a Brazilian tertiary pediatric hospital during the COVID-19 pandemic. Clinical samples were processed in the BACT/ALERT® 3D system or on agar plates. Definitive identification was achieved by MALDI-TOF MS. Antifungal susceptibility was initially analyzed by the VITEK 2 system (AST-YS08 card) and confirmed by the CLSI protocol. Patient data were collected from the medical records using a structured questionnaire. CPC was recovered from 124 patients over an 18-month period, as follows: C. parapsilosis (83.87%), C. orthopsilosis (13.71%) and C. metapsilosis (2.42%). Antifungal resistance was not detected. The age of the patients with invasive CPC infections ranged from <1 to 18 years, and most of them came from oncology-related sectors, as these patients were more affected by C. parapsilosis. C. orthopsilosis infections were significantly more prevalent in patients from critical care units. Invasive infections caused by different pathogens occurred in 75 patients up to 30 days after the recovery of CPC isolates. Overall, 23 (18.55%) patients died within 30 days of CPC diagnosis. Catheter removal and antifungal therapy were important measures to prevent mortality. COVID-19 coinfection was only detected in one patient.

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Section: Discussionmentioning

confidence: 99%