Prevalência de anticorpos para o vírus da varicela-zoster em adultos jovens de diferentes regiões climáticas brasileiras

Reis, Alexanda Dias; Pannuti, Cláudio Sérgio; Souza, Vanda Akico Ueda Fick de

doi:10.1590/s0037-86822003000300001

Cited by 21 publications

(22 citation statements)

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“…There is no clear definition in the literature establishing an anti-VZV antibody titer value (as measured by ELISA) that would be considered protective (13,17). In a recently published article, Li et al demonstrated a correlation between antibody titers and protection using the gpELISA, which detects anti-VZV glycoprotein antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…The anti-VZV antibodies were detected by immunosorbent assay, using an in-house assay developed by Reis et al (13). An anti-VZV antibody titer greater than 100 mAU/mL was considered positive by the standardized method (13). We decided to vaccinate those patients presenting anti-VZV antibody titers lower than 500 mAU/mL.…”

Section: Quantitation Of Anti-vzv Antibodiesmentioning

confidence: 99%

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Seroprevalence of antibodies against varicella‐zoster virus and response to the varicella vaccine in pediatric renal transplant patients

Chaves¹,

Lopes²,

Souza

et al. 2005

Pediatric Transplantation

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The severity of varicella-zoster virus (VZV) in immunocompromised children, especially in those receiving renal transplants, is well known. However, the use of live attenuated virus vaccine in this population is controversial. This study aimed to: (i) assess the immunization status of pediatric renal transplant recipients at our center; (ii) determine the anti-VZV antibody titers in such patients; (iii) evaluate the response to VZV vaccine in seronegative children and in those who present low antibody titers (defined as <500 mAU/mL). Vaccinated children were monitored for adverse effects for 8 wk after vaccination. Fifty patients with a mean age of 13.7 yr (range, 3-17 yr) were enrolled. In 49, blood samples were collected and antibodies were screened using ELISA. Seropositivity to VZV was found in 43 (88%), and antibody titers were >/=500 mAU/mL in 37 (75.5%). Of the 12 children who were eligible for vaccination and had antibody titers <500 mAU/mL, one developed varicella before vaccination, two did not meet the inclusion criteria, and three parents refused the vaccination. In the six vaccinated children, there were no adverse reactions to the vaccine, and four (66.6%) responded with anti-VZV titers >/=500 mAU/mL 6-8 wk after vaccination. In conclusion, after renal transplantation, varicella vaccine is safe with a 66% rate of conversion to high antibody titers.

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Section: Discussionmentioning

confidence: 99%

Section: Quantitation Of Anti-vzv Antibodiesmentioning

confidence: 99%

Seroprevalence of antibodies against varicella‐zoster virus and response to the varicella vaccine in pediatric renal transplant patients

Chaves¹,

Lopes²,

Souza

et al. 2005

Pediatric Transplantation

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“…América (AAP/CDC, 2003), dados brasileiros (BRASIL, 2003b;BRASIL, 2003c) e dados da cidade de São Paulo (CVE, 2003d;CVE, 2003e SOUZA et al, 1997;YU et al, 2000;MACHADO et al, 2002;REIS et al, 2003).…”

Section: Os Dados Foram Comparados Com Dados Dos Estados Unidos Daunclassified

“…Para varicela, o cut off do teste foi calculado pela média, mais três desvios padrões das DOs (densidades ópticas) de vinte amostras sabidamente negativas. O título considerado protetor para a doença foi igual e/ou superior a 100 mUA/ml (REIS et al, 2003).…”

Section: 1a Quanto Aos Critérios De Inclusão Dos Pacientesunclassified

"Levantamento da situação vacinal e avaliação sorológica para sarampo e varicela de crianças e adolescentes portadores de insuficiência renal crônica em tratamento conservador e dialítico"

Fagundes¹

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“…Varicela é uma doença exantemática benigna e freqüente na infância (STOCCO et al, 1990;MANDELL et al, 2000;YU et al, 2000;WAREHAM e BREUER, 2000;ABARCA et al, 2001;LAW, 2001;YOSHINORI et al, 2001;DEL PONT et al, 2002;FELDMAN, 2002). Embora seja uma importante causa de morbidade em todos os grupos etários, a infecção ocorre primariamente em crianças (CLEMENS et al, 1999;REIS et al, 2003).…”

Section: Introductionunclassified

Estudo de fatores preditores de gravidade e óbito por varicela em residentes da região metropolitana da grande São Paulo (SP), 2003

Pellini¹

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Introduction: Chickenpox is a benign exanthematous disease of childhood, whose primary infection is caused by the Varicella-zoster virus. In the State of São Paulo, in 2003, 58,972 chickenpox cases were notified following outbreaks, configuring a hyperendemic year for the disease. From a total of 60 deaths in the whole State, 47 happened in children up to 4 years old. More than half of the deaths occurred in residents of the Greater São Paulo Metropolitan Area. Objectives: To describe and characterize those individuals residents in the Greater São Paulo Metropolitan Area who developed chickenpox severity or death during the year 2003, and to study the predictive factors of these events. Method: A descriptive study was performed, analyzing clinical and social-demographic variables, personal and epidemiological records of the chickenpox cases. Besides, an exploratory analysis of the predictive factors of severity and death by the disease was made. Association between exposures of interest and chickenpox severity or death was investigated by unadjusted and adjusted odds ratio estimation, with 95% confidence intervals, using unconditional logistic regression. Results: The following variables keep an independent association with severity and death for chickenpox: development of rare, pulmonary, hemorrhagic and neurological complications. The need of surgery during the chickenpox hospitalization was an independent predictive factor for severity only. The mortality rate was 36 times greater in the age group from 0 to 14 years old than in the adult age group, and 5 times greater in children up to 1 year old than in the age group ranging from 0 to 14 years old. Conclusion: The comprehensive knowledge of the chickenpox epidemiology, its complications and risk factors for severity and death is extremely important to base the implementation of prevention and control strategies for groups at greater risk of infection.

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Prevalência de anticorpos para o vírus da varicela-zoster em adultos jovens de diferentes regiões climáticas brasileiras

Cited by 21 publications

References 11 publications

Seroprevalence of antibodies against varicella‐zoster virus and response to the varicella vaccine in pediatric renal transplant patients

Seroprevalence of antibodies against varicella‐zoster virus and response to the varicella vaccine in pediatric renal transplant patients

"Levantamento da situação vacinal e avaliação sorológica para sarampo e varicela de crianças e adolescentes portadores de insuficiência renal crônica em tratamento conservador e dialítico"

Estudo de fatores preditores de gravidade e óbito por varicela em residentes da região metropolitana da grande São Paulo (SP), 2003

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