Prevalencia de anemia asociada a la enfermedad pulmonar obstructiva crónica. Estudio de las variables asociadas

Casanova, Lorena Aida Comeche; Echave-Sustaeta, José; Luján, Ricardo García; Albarrán, Irene; Alonso-González, Pablo; Alonso, María J.

doi:10.1016/j.arbres.2013.04.007

Cited by 12 publications

(6 citation statements)

References 24 publications

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“…The criteria used to identify anemia by Cote et al( <13 g/dL independently from gender ) [ 5 ], and the difference in the population studied (subjects with COPD from the US Medicare Claims Database, in the study carried out by Halpern et al [ 18 ]) can justify the discrepancy of the results. Only Casanova et al [ 29 ] reported a prevalence of anemia that was lower (6.2%) than the one found in the present study.…”

Section: Discussioncontrasting

confidence: 94%

Anemia and hemoglobin serum levels are associated with exercise capacity and quality of life in chronic obstructive pulmonary disease

et al. 2015

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BackgroundLittle is known about the relationship between hemoglobin concentrations, functional status and health related quality of life (HRQL) in chronic obstructive pulmonary disease (COPD). Our aim was to investigate the prevalence of anemia and the association of hemoglobin with shortness of breath, exercise capacity, muscle strength and HRQL, in COPD patients.MethodsA total of 105 COPD patients (77 males, 71.6 ± 9.2 years) were studied. Patients were classified as anemic and non anemic using the WHO criteria. We used the Medical Research Council Dyspnoea scale (MRCs) to measure shortness of breath. Exercise capacity was assessed using the six minute walking distance (6MWD) and the peak of VO2 during the maximal cycle ergometer test (VO2max). We used the Quadriceps and Handgrip strength assessment to determine muscle strength. The Saint George Respiratory Questionnaire was used to investigate HRQL. The physiological/functional characteristics of the two groups were compared. Regression models adjusting for confounders examined the independent association of anemia and of hemoglobin levels with clinical and functional outcomes.ResultsAnemic patients (12.3%) showed a significantly higher MRCs, a lower 6MWD, VO2max, and a worse quality of life. On the contrary, there was no difference in muscle strength between the two groups. In the regression models, hemoglobin was independently associated with reduced exercise capacity and HRQL.ConclusionsAnemia in COPD was a risk factor for poorer exercise capacity and quality of life, and these outcomes were linearly associated with hemoglobin. Our results should stimulate further research into exploring whether increasing hemoglobin has a beneficial effect on the outcomes in COPD.

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Section: Discussioncontrasting

confidence: 94%

Anemia and hemoglobin serum levels are associated with exercise capacity and quality of life in chronic obstructive pulmonary disease

et al. 2015

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“…Surprisingly, there are scarce data about ID in COPD. Recently, Comeche Casanova et al have shown in a cohort of 130 patients with stable COPD that serum iron was significantly lower in anemic patients than in those without anemia [29]. …”

Section: Discussionmentioning

confidence: 99%

“…Anemia in patients with COPD is likely due to a combination of several factors [26,29,33]: (i) Elevated cytokines levels, especially Tumor Necrosis Factor alpha (TNF α) and interleukin-6 (IL-6) [1,12,17,18,34,35]. Moreover, persistent inflammation may be associated with poor clinical outcome for COPD patients [36].…”

Section: Discussionmentioning

confidence: 99%

Anemia and iron deficiency in COPD patients: prevalence and the effects of correction of the anemia with erythropoiesis stimulating agents and intravenous iron

et al. 2014

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BackgroundLittle is known about iron deficiency (ID) and anemia in Chronic Obstructive Pulmonary Disease (COPD). The purposes of this study were: (i) To study the prevalence and treatment of anemia and ID in patients hospitalized with an exacerbation of COPD. (ii) to study the hematological responses and degree of dyspnea before and after correction of anemia with subcutaneous Erythropoiesis Stimulating Agents (ESAs) and intravenous (IV) iron therapy, in ambulatory anemic patients with both COPD and chronic kidney disease.Methods(i) We examined the hospital records of all patients with an acute exacerbation of COPD (AECOPD) to assess the investigation, prevalence, and treatment of anemia and ID. (ii) We treated 12 anemic COPD outpatients with the combination of ESAs and IV-iron, given once weekly for 5 weeks. One week later we measured the hematological response and the severity of dyspnea by Visual Analogue Scale (VAS).Results(i) Anemia and iron deficiency in hospitalized COPD patients: Of 107 consecutive patients hospitalized with an AECOPD, 47 (43.9%) were found to be anemic on admission. Two (3.3%) of the 60 non-anemic patients and 18 (38.3%) of the 47 anemic patients had serum iron, percent transferrin saturation (%Tsat) and serum ferritin measured. All 18 (100%) anemic patients had ID, yet none had oral or IV iron subscribed before or during hospitalization, or at discharge. (ii) Intervention outpatient study: ID was found in 11 (91.7%) of the 12 anemic ambulatory patients. Hemoglobin (Hb), Hematocrit (Hct) and the VAS scale scores increased significantly with the ESAs and IV-iron treatment. There was a highly significant correlation between the ∆Hb and ∆VAS; rs = 0.71 p = 0.009 and between the ∆Hct and ∆VAS; rs = 0.8 p = 0.0014.ConclusionsID is common in COPD patients but is rarely looked for or treated. Yet correction of the ID in COPD patients with ESAs and IV iron can improve the anemia, the ID, and may improve the dyspnea.

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“…Of 107 consecutive patients hospitalized with an acute exacerbation of COPD patients (AECOPD), 47 (43.9%) were found to be anemic on admission in a study by Silverberg et al [13] One recent study by El-Korashy et al [14] showed that almost half of patients have anemia; however, one earlier study reported a very low prevalence of anemia in COPD patients that is 6%. [15]…”

Section: Discussionmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease with Anemia as Comorbidity in North Indian Population

et al. 2018

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Background:Chronic obstructive pulmonary disease (COPD) is an increasing cause of morbidity and mortality worldwide. Anemia is seen as a common comorbidity in COPD patients associated with reduced functional capacity, impaired quality of life, greater likelihood of hospitalization, and early mortality. The aim is to study the prevalence of anemia in patients with COPD and to study its association with different parameters.Materials and Methods:In the present case–control study, 150 stable COPD patients were enrolled from the Outpatient Department of Respiratory Medicine, King George Medical University, Lucknow, from October 2015 to January 2017. GraphPad PRISM version 6.01 was used for the analysis of data. Chi-square test was used to compare between the groups. P < 0.05 was considered statistically significant.Results:The present study showed the prevalence of anemia in COPD patients to be 31.6%. The mean hemoglobin level in anemic group was 11.04 ± 1.1 g/dl, whereas in nonanemic group, it was 13.9 ± 0.8 g/dl. Anemia was significantly associated with increased dyspnea in our study which was assessed by modified Medical Research Council grade (P = 0.04).Conclusion:The prevalence of anemia in COPD patients was 31.6%. Anemia is present as comorbidity in COPD patients and is associated with poor quality of life and increased morbidity in the form of number of exacerbation and hospital admission. Identification and correction of anemia in COPD patients may improve their clinical outcome.

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Prevalencia de anemia asociada a la enfermedad pulmonar obstructiva crónica. Estudio de las variables asociadas

Cited by 12 publications

References 24 publications

Anemia and hemoglobin serum levels are associated with exercise capacity and quality of life in chronic obstructive pulmonary disease

Anemia and hemoglobin serum levels are associated with exercise capacity and quality of life in chronic obstructive pulmonary disease

Anemia and iron deficiency in COPD patients: prevalence and the effects of correction of the anemia with erythropoiesis stimulating agents and intravenous iron

Chronic Obstructive Pulmonary Disease with Anemia as Comorbidity in North Indian Population

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