Prevalences and pregnancy outcome of vanishing twin pregnancies achieved by in vitro fertilization versus natural conception

Abstract

Vanishing twin pregnancies had a lower prevalence and a worse perinatal outcome after IVF-ICSI as compared with those of their spontaneously conceived counterparts.

Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review

“…However, an effect of vanishing twin syndrome (VTS) [34], as consequence of DET or multiple embryo transfer, cannot be excluded. This is particularly true in consideration of the higher risk of pregnancy complications observed in VTS pregnancies from IVF/ICSI cycles in comparison with VTS pregnancies from NC [35]. A large cohort study including 7,757 deliveries following IVF/ICSI procedures found more adverse outcomes among VTS survivors occurring after 8 weeks of gestation, even after adjustment for maternal age and parity [36].…”

“…To this regard, a recent retrospective matched (for maternal age, previous gravidity, parity, and prepregnancy BMI) analysis demonstrated that the incidence of the VTS in infertile IVF/ICSI patients is lower than in NC (12.6 % vs. 18.2 %, respectively; estimated for twin pregnancies) but the perinatal outcomes resulted worse. In fact, the risk of GDM (aOR 3.0, 95 % CI 1.6 to 5.6 vs. aOR 0.46, 95 % CI 0.2 to 1.1) and of PE (aOR 1.6, 95 % CI 0.7 to 6.1 vs. aOR 1.00, 95 % CI 0.8 to 1.8) in VTS pregnancies was very high in IVF/ICSI patients but lower or unchanged in NC women [35]. Also the incidence of IUGR (aOR 3.0, 95 % CI 1.8 to 5.2 vs. aOR 9.2, 95 % CI 5 to 22) and of LBW (aOR 4.0, 95 % CI 1.8 to 7.1 vs. aOR 2.1, 95 % CI 1.6 to 4.0) in VTS pregnancies was higher in IVF/ICSI patients than in NC women [35].…”

“…In fact, the risk of GDM (aOR 3.0, 95 % CI 1.6 to 5.6 vs. aOR 0.46, 95 % CI 0.2 to 1.1) and of PE (aOR 1.6, 95 % CI 0.7 to 6.1 vs. aOR 1.00, 95 % CI 0.8 to 1.8) in VTS pregnancies was very high in IVF/ICSI patients but lower or unchanged in NC women [35]. Also the incidence of IUGR (aOR 3.0, 95 % CI 1.8 to 5.2 vs. aOR 9.2, 95 % CI 5 to 22) and of LBW (aOR 4.0, 95 % CI 1.8 to 7.1 vs. aOR 2.1, 95 % CI 1.6 to 4.0) in VTS pregnancies was higher in IVF/ICSI patients than in NC women [35]. Very interesting data from multiple logistic regression analyses that identified in VTS pregnancies obtained after IVF/ICSI cycles a risk of IUGR 28-fold higher (aOR 28.2, 95 % CI 2.2 to 14.5) [35].…”

“…Also the incidence of IUGR (aOR 3.0, 95 % CI 1.8 to 5.2 vs. aOR 9.2, 95 % CI 5 to 22) and of LBW (aOR 4.0, 95 % CI 1.8 to 7.1 vs. aOR 2.1, 95 % CI 1.6 to 4.0) in VTS pregnancies was higher in IVF/ICSI patients than in NC women [35]. Very interesting data from multiple logistic regression analyses that identified in VTS pregnancies obtained after IVF/ICSI cycles a risk of IUGR 28-fold higher (aOR 28.2, 95 % CI 2.2 to 14.5) [35]. …”

Twinning as an Evolved Age-Dependent Physiological Mechanism: Evidence from Large Brazilian Samples

“…In the past, this occurred without women's knowledge, but with the use of ultrasonography fetal resorption is more frequently diagnosed. Monitoring 228 twin pregnancies after natural conception, Márton et al [51] reported an incidence of vanishing twin syndrome in 18.2% of twins, although it varies considerably, from 0 to 100% [39].…”