Prevalence Trends of Site‐Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019

Abstract

Objective To estimate systematic and anatomic site–specific age‐standardized prevalence rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and national levels. Methods Data were derived from the Global Burden of Disease Study 2019. ASRs and their estimated annual percentage changes (EAPCs) were used to describe the secular trends of OA according to age group, sex, region, country, and territory, as well as the joints involved. Results Globally, prevalent cases of OA increased by 113.25%, from 247.51 million in 1990 to 527.81 million in 2019. ASRs were 6,173.38 per 100,000 in 1990 and 6,348.25 per 100,000 in 2019, with an average annual increase of 0.12% (95% confidence interval [95% CI] 0.11%, 0.14%). The ASR of OA increased for the knee, hip, and other joints, but decreased for the hand, with EAPCs of 0.32 (95% CI 0.29, 0.34), 0.28 (95% CI 0.26, 0.31), 0.18 (95% CI 0.18, 0.19), and −0.36 (95% CI −0.38, −0.33), respectively. OA prevalence increased with age and revealed female preponderance, geographic diversity, and disparity with regard to anatomic site. OA of the knee contributed the most to the overall burden, while OA of the hip had the highest EAPC in most regions. Conclusion OA has remained a major public health concern worldwide over the past decades. The prevalence of OA has increased and diversified by geographic location and affected joint. Prevention and early treatment are pivotal to mitigating the growing burden of OA.

Tackling Unmet Medical Need: How Slow-Release Intra-articular Corticosteroids Could Play a Role in Improving Quality of Life and Reducing Risk in Osteoarthritis

“…Affected joints vary, but the most common site is the knee, followed by the hand and the hip. 1 While younger people may experience trauma-initiated OA, it is primarily an age-related condition attributable to slow accumulation of structural damage over time. 1 In line with ageing populations worldwide, its prevalence among older people is on the increase.…”

“…1 While younger people may experience trauma-initiated OA, it is primarily an age-related condition attributable to slow accumulation of structural damage over time. 1 In line with ageing populations worldwide, its prevalence among older people is on the increase. Data from the 2019 Global Burden of Disease (GBD) study show a 113.25% increase in cases, from 247.51 million to 527.81 million, between 1990 and 2019.…”

“…The same period also saw a 114.5% increase in years lived with disability caused by OA. 1 OA is the fastest growing cause of disability worldwide, 2 and the impact can be significant, said Conaghan. "Not everyone has severe symptoms, but roughly one-third will have severe symptoms with impact on QoL," Conaghan told EMJ.…”

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“…Simultaneously, bone turnover is increased, leading to subchondral bone thickening and osteophytes formation on the joint margins, all of which signify aberrant bony remodeling in the joint [ 3 ]. Recently published data on OA prevalence indicate that as of 2019, there were more than 500 million OA cases globally [ 4 ]. With a lack of reliable treatment options, patients with OA suffer chronically from pain and loss of mobility, leading to a significant financial burden on the medical system, as well as on the individuals, due to the disease [ 5 ].…”

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“…Osteoarthritis (OA) is the most common rheumatic condition over the world and its prevalence is rising due to the increasing obesity and life span of the general population. It is estimated that the number of people affected by this condition will increase by approximately 50% over the next 20 years ( Hunter and Bierma-Zeinstra, 2019 ; Long et al, 2022 ).…”