Prevalence, treatment, and outcome of heart disease in live-born children: A prospective analysis of 91,823 live-born children

Šamánek, M; Slavík, Zdeněk; Zbořilová, B; Hrobonová,; Vorísková, M; Škovránek, J

doi:10.1007/bf02083294

Cited by 252 publications

(117 citation statements)

References 9 publications

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“…The most frequent abnormalities were the interventricular communication and the patent ductus arteriosus 19 .…”

Section: Discussionmentioning

confidence: 99%

“…Šamánek 19,20 and Brent 21 reported a prevalence of 6.2% of congenital cardiopathies in necropsies, responsible for 7.4% of the total mortality among live births and 41.4% of the congenital malformations diagnosed in Bohemia, currently the Czech Republic for 25 years, before the introduction of advanced methods of neonatal cardiac surgery. The most frequent abnormalities were the interventricular communication and the patent ductus arteriosus 19 .…”

Section: Discussionmentioning

confidence: 99%

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Malformações cardíacas congênitas em necropsias pediátricas: características, associações e prevalência

Leite¹,

Miziara²,

Veloso³

2010

Arq. Bras. Cardiol.

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Background: In Brazil, since 2001, the congenital abnormalities have represented the second cause of death in children younger than one year, with cardiovascular defects being responsible for 39.4% of these deaths.Objectives: To establish the prevalence and the characteristics of the congenital cardiac malformations in pediatric necropsies performed in Hospital Regional da Asa Sul, Brasília, DF, Brazil, from January 1996 to December 2007.Methods: This is a descriptive, cross-sectional study that reviewed 1,591 necropsies performed from January 1996 to December 2007 and found 189 (11.9%) with congenital cardiac malformations, included in this study.Results: The cardiac abnormalities were observed mainly in the group of live births (117/61.9%), followed by the stillbirths (35/18.5%), the infant group (30/15.9%) and the preschoolers' group (7/3.7%), with no cases identified among schoolaged children. The main alterations detected were: interatrial communication in 96 patients (27%), interventricular communication in 66 patients (18.5%) and patent ductus arteriosus in 51 (14.3%), with no predominance of either sex. In 133 patients (70.4%), the cardiopathies were multiple and in 96 (50.8%) they were associated with anomalies in other organs and systems; among these, 45 (23.8%) presented cardiopathies as syndrome components, especially trisomies, at all age ranges. Conclusions:The results of the present study show a high prevalence of congenital cardiac anomalies in our country and distribution and association that were similar to the ones observed in developed countries. The high mortality associated to such anomalies highlights the need for more comprehensive research in order to identify the risk factors and seek the primary prevention of some of these defects. ( awareness of the most prevalent anomalies and the possible associated risk factors can allow an early intervention directed at primary prevention, with a positive impact on the quality of life of the child and its family.The aims of the present study are to estimate the prevalence and study the morphologic characteristics of congenital cardiac malformations identified in pediatric necropsies performed at Hospital Regional da Asa Sul, Brasília, DF, Brazil, from January 1996 to December 2007. MethodsA descriptive, cross-sectional study was carried out, which consisted in the review of patients' files from the Cytopathologic and Pathologic Anatomy Center of Hospital Regional da Asa Sul (HRAS), of all deaths that occurred in this hospital between January 1996 and December 2007. The HRAS is a public hospital and a reference one for high-risk pregnancies in the Federal District (DF).Among the necropsies performed at the HRAS, all that presented cardiac malformations were reviewed by the author and a pathologist. The following variables were analyzed: maternal and child's age, necropsy diagnosis, sex, cardiac malformations and associated ones. Cardiorespiratory IntroductionCongenital malformations are associated with high mortality and it has been estima...

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“…The most frequent abnormalities were the interventricular communication and the patent ductus arteriosus 19 .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Malformações cardíacas congênitas em necropsias pediátricas: características, associações e prevalência

Leite¹,

Miziara²,

Veloso³

2010

Arq. Bras. Cardiol.

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“…La coartación aórtica (CoAo) es una cardiopatía congénita que tiene una prevalencia del 5 al 8% de todos los defectos congénitos del corazón [1][2][3][4] . En el 85% de los casos se asocia con aorta bicúspide y en el 3 al 10% con estenosis subvalvular, valvular o supravalvular aórtica 4 .…”

Section: Introductionunclassified

Disfunción ventricular subclínica por Speckle Tracking en pacientes adultos con coartación de aorta

Espínola‐Zavaleta

Rúan-Díaz

Soto

et al. 2019

GMM

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“…In cats, TOF has also been rarely reported [4]. However, the actual prevalence may be higher than has been reported previously, because severely affected animals commonly die at a young age before having been thoroughly examined [7].Pentalogy of Fallot (POF) is a more complex congenital cardiac malformation characterised by TOF with either an atrial septal defect (ASD) or patent foramen ovale [12]. It also occurs in association with right aortic arch abnormalities or coronary arterial abnormalities in humans [3].…”

mentioning

confidence: 99%

“…Pentalogy of Fallot (POF) is a more complex congenital cardiac malformation characterised by TOF with either an atrial septal defect (ASD) or patent foramen ovale [12]. It also occurs in association with right aortic arch abnormalities or coronary arterial abnormalities in humans [3].…”

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confidence: 99%

Pentalogy of Fallot in a Korean Sapsaree Dog

Park

Lee

Kim

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. A 5-month-old female Korean Sapsaree dog was presented with severe ascites, cyanosis, respiratory difficulty and exercise intolerance. Diagnostic imaging studies revealed a dextropositioned and over-riding aorta, pulmonary valvular stenosis, ventricular and atrial septal defects, and right ventricular hypertrophy. Based on these findings, the dog was diagnosed as a case of tetralogy of Fallot with atrial septal defect (pentalogy of Fallot). The dog was medically managed by use of diuretics and vasodilators and an occasional phlebotomy. KEY WORDS: congenital heart disease, Korean Sapsaree, pentalogy of Fallot.J. Vet. Med. Sci. 69(1): 73-76, 2007 Tetralogy of Fallot (TOF) is a rare complex congenital cardiac defect characterised by a ventricular septal defect (VSD) with an overriding aorta, pulmonic stenosis (PS) and right ventricular hypertrophy. In dogs, TOF is rare (0.25/ 1000 dogs examined) [9]. In cats, TOF has also been rarely reported [4]. However, the actual prevalence may be higher than has been reported previously, because severely affected animals commonly die at a young age before having been thoroughly examined [7].Pentalogy of Fallot (POF) is a more complex congenital cardiac malformation characterised by TOF with either an atrial septal defect (ASD) or patent foramen ovale [12]. It also occurs in association with right aortic arch abnormalities or coronary arterial abnormalities in humans [3]. Increased resistance to right ventricular outflow tract (RVOT), caused by PS, result in R-L shunting of venous blood (responsible for cyanosis). Moreover RVOT obstruction, caused by PS and accounting for RV pressure overload and subsequent RV (right ventricle) hypertrophy, will contribute to the R-L (right to left) shunting.Several genetic aetiologies including Jagged-1 [5], NKX2-5 (NK2 transcription factor) [6] and ZFPM2 (zinc finger protein multitype 2) [11] have been identified in human TOF. Autosomal recessive inheritance and a possible genetic aetiology have been observed with TOF in Keeshond dogs [10,15], as this breed had been intentionally inbred. Further pedigree and clinical studies of family members is warranted to clarify a genetic etiology.A 5-month-old intact female Sapsaree (9.5 kg, Korean native dog), was presented at the Veterinary Teaching Hospital, Kangwon National University with signs of severe dyspnea, ascites, exercise intolerance and cyanosis. On thoracic auscultation, a grade V/VI holosystolic murmur was heard at the left and right apical region of the heart with a precordial thrill.On the day of presentation, electrocardiographic studies showed a sinus tachycardia (120 beats per min) with right axis deviation (+120°) of an abnormal QRS-complex with S-waves in leads I, II, III, indicating right ventricular hypertrophy (Fig. 1). No significant abnormalities were observed in routine hematology and blood chemistry except polycythemia (58% of packed cell volume; normal range: 37-55%). Radiographic studies of the thoracic and abdominal cavities revealed a global shaped cardiac ...

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Prevalence, treatment, and outcome of heart disease in live-born children: A prospective analysis of 91,823 live-born children

Cited by 252 publications

References 9 publications

Malformações cardíacas congênitas em necropsias pediátricas: características, associações e prevalência

Malformações cardíacas congênitas em necropsias pediátricas: características, associações e prevalência

Disfunción ventricular subclínica por Speckle Tracking en pacientes adultos con coartación de aorta

Pentalogy of Fallot in a Korean Sapsaree Dog

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