2016
DOI: 10.1007/s00296-016-3526-z
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Prevalence, severity, and clinical features of acute and chronic pancreatitis in patients with systemic lupus erythematosus

Abstract: Pancreatitis is a rare, life-threatening complication of systemic lupus erythematosus (SLE). This study aimed to describe the clinical features of acute pancreatitis (AP) and chronic pancreatitis (CP) in patients with SLE. Data of patients who fulfilled the revised criteria of the American Rheumatism Association for diagnosis of SLE were retrospectively analyzed. SLE activity was graded according to the SLE Disease Activity Index. Logistic regression analysis was conducted to find out independent associations.… Show more

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Cited by 31 publications
(51 citation statements)
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References 19 publications
(27 reference statements)
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“…12 Corticosteroids should be used for the medical management of SLE-related acute pancreatitis; in particular, treatment with additional steroids at high doses has been successful in the management of SLE-related pancreatitis. 2,13 In this report, the patient developed SLE-related acute pancreatitis concurrently with lupus nephritis; both complications were successfully treated with corticosteroids. Immunosuppressive agents such as mycophenolate mofetil or cyclophosphamide can be used in combination with corticosteroids.…”
Section: Figure1 Laboratory Results During Treatment Of Pancreatitismentioning
confidence: 79%
See 1 more Smart Citation
“…12 Corticosteroids should be used for the medical management of SLE-related acute pancreatitis; in particular, treatment with additional steroids at high doses has been successful in the management of SLE-related pancreatitis. 2,13 In this report, the patient developed SLE-related acute pancreatitis concurrently with lupus nephritis; both complications were successfully treated with corticosteroids. Immunosuppressive agents such as mycophenolate mofetil or cyclophosphamide can be used in combination with corticosteroids.…”
Section: Figure1 Laboratory Results During Treatment Of Pancreatitismentioning
confidence: 79%
“…Good supportive measures are helpful for facilitating functional recovery and improving patient outcomes 2 . In severe cases, plasmapheresis and intravenous gamma-globulin infusion may be beneficial 13 . Our case suggests that methylprednisolone pulse therapy should be promptly administered if clinical and biochemical investigation suggest that SLE is responsible for pancreatitis.…”
Section: Figure1 Laboratory Results During Treatment Of Pancreatitismentioning
confidence: 99%
“…12 Se deben usar corticoesteroides para el tratamiento médico de la pancreatitis aguda asociada a LES; en particular, el tratamiento con corticoesteroides en dosis altas adicionales ha sido satisfactorio en el manejo de la pancreatitis asociada a LES. 2,13 La paciente descrita en este informe desarrolló pancreatitis aguda asociada a LES concurrente con nefritis lúpica; ambas complicaciones se trataron adecuadamente con corticoesteroides. Los agentes inmunosupresores, como micofenolato mofetilo o ciclofosfamida, p u e d e n u s a r s e e n c o m b i n a c i ó n c o n corticoesteroides.…”
Section: Discussionunclassified
“…The high mortality rate in SLE pancreatitis is associated with severe disease activity, thrombocytopenia and acute renal failure (3,4,6). Due to clinically significant renal failure, our patient was referred to haemodialysis treatment via CVK.…”
Section: Figure 1 Computed Tomography Scans (A) (B) (C) Show Enlarmentioning
confidence: 99%
“…Other biochemical abnormalities include hypertriglyceridemia, hypocalcaemia, hypoalbuminemia, abnormal liver function tests and elevated serum creatinine. The exact pathogenic mechanisms of SLE related pancreatitis are not clear, but are probably mediated by immune complex-induced microangiitis (2)(3)(4).…”
Section: Introductionmentioning
confidence: 99%