Prevalence, risk factors and sequelae of Staphylococcus aureus carriage in diabetes: the Fremantle Diabetes Study Phase II

Hart, Julie; Hamilton, Emma; Makepeace, Ashley; Davis, Wendy A.; Latkovic, Erin; Lim, Ee Mun; Dyer, John; Davis, Timothy

doi:10.1016/j.jdiacomp.2015.06.005

Cited by 23 publications

(20 citation statements)

References 28 publications

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“…From the aforementioned statistics, we know that the prevalence of S. aureus nasal colonization was lower in this community-based diabetes population than in the hospital-based 30 and 2014 (44.60%) 31 in China, which can be partially explained by the high prevalence of MRSA nasal colonization in the present community-based diabetes population. However, there was no statistical difference in the prevalence of S. aureus and MRSA nasal colonization between the two populations, which was consistent with several studies 19,32 .…”

Section: Discussionsupporting

confidence: 92%

“…The proportion of MRSA nasal colonization in S. aureus strains (47.83%, 22/46) among the diabetes population in the present study was higher than the nationally average proportion of MRSA in S. aureus strains in 2013 (45.20%) and 2014 (44.60%) in China, which can be partially explained by the high prevalence of MRSA nasal colonization in the present community‐based diabetes population. However, there was no statistical difference in the prevalence of S. aureus and MRSA nasal colonization between the two populations, which was consistent with several studies.…”

Section: Discussionsupporting

confidence: 92%

“…The present study adds to the existing knowledge by giving insight into the genotypic and phenotypic characteristics of S. aureus and MRSA nasal colonization among the diabetes population in community settings. The prevalence of S. aureus (8.70%, 46/529) nasal colonization among the community-based diabetes population in this study was lower than those of a diabetic outpatient population in Turkey (41.78%, 127/304) 21 , longterm hemodialysis type 2 diabetes patients in Saudi Arabia (72.41%, 42/58) 28 , hospitalized diabetic patients in India (56.67%, 34/60) 17 , diabetes patients in Australia (39.09%, 258/ 660) 19 , hospitalized diabetic patients (20.50%, 41/200) in China 20 and type 2 diabetes outpatients in China (10.31%, 43/417) 21 .…”

Section: Discussioncontrasting

confidence: 60%

“…The prevalence of MRSA (4.16%, 22/529) nasal colonization among the community-based diabetes population in this study was lower than those of type 2 diabetes patients in China (5.28%, 22/417) 18 , a diabetic outpatient population in Turkey (9.87%, 30/304) 21 and long-term hemodialysis type 2 diabetes patients in Saudi Arabia (18.97%, 11/58) 28 , but was higher than those of hospitalized diabetic patients in China (0.50%, 1/ 200) 20 , diabetes patients in Australia (1.21%, 8/660) 19 and type 1 diabetes pediatric outpatients in Turkey (in 2005, 0.99%, 1/101; in 2013, 0.75%, 1/134) 29 .…”

Section: Discussionmentioning

confidence: 86%

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Prevalence and characteristics of Staphylococcus aureus and methicillin‐resistant Staphylococcus aureus nasal colonization among a community‐based diabetes population in Foshan, China

Lin

Yang

et al. 2016

J of Diabetes Invest

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Aims/IntroductionEvidence suggests that diabetes might cause an increase in colonization of Staphylococcus aureus (S. aureus) and methicillin‐resistant S. aureus (MRSA) in community settings. We carried out a cross‐sectional study to determine the prevalence and influencing factors of S. aureus and MRSA nasal colonization among a community‐based diabetes population, and to identify the characteristics of the isolated strains.Materials and MethodsA total of 956 participants from 11 community settings were included in the study.ResultsOf the 529 diabetes participants, 46 were colonized with S. aureus and 22 were colonized with MRSA. Of the 427 non‐diabetes participants, 25 were colonized with S. aureus and 12 were colonized with MRSA. Men (odds ratio 0.45, 95% confidence interval 0.20–0.99, P = 0.047) were less likely to have S. aureus nasal colonization, and those with well‐controlled blood glucose (odds ratio 2.04, 95% confidence interval 1.01–4.13, P = 0.047) among the diabetes population were more likely to have S. aureus nasal colonization. The proportion of multidrug‐resistant S. aureus strains in the diabetes population (52.17%) was higher than that in the non‐diabetes population (28.00%; χ2 = 3.848, P = 0.050). The most common clonal complex type and Staphylococcal chromosome cassette mec type of MRSA in diabetes population was clonal complex 5 (40.91%) and type IV (27.27%), respectively. The proportion of Panton–Valentine leukocidin gene in MRSA strains was 17.65%. There was great sequence type diversity in MRSA strains.ConclusionsThe prevalence of MRSA in the community‐based diabetes population was moderate, and the high proportions of multidrug‐resistant S. aureus strains and diverse molecular characteristics in the diabetes population should be noticed.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 86%

See 2 more Smart Citations

Prevalence and characteristics of Staphylococcus aureus and methicillin‐resistant Staphylococcus aureus nasal colonization among a community‐based diabetes population in Foshan, China

Lin

Yang

et al. 2016

J of Diabetes Invest

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“…Carriage of MRSA has been associated with an increased risk of subsequent infection—both nosocomial and community‐acquired (Wertheim et al, ). A number of studies in Australia have estimated a low prevalence of MRSA carriage; 3.1% in diabetes outpatients in Perth (Hart et al, ), 2.2% in new hospital admissions in Darwin (Brennan et al, ) and 0.7% in the general community in Brisbane (Munckhof et al, ). In contrast, the prevalence of MRSA carriage in an Aboriginal community in Queensland was as high as 15% (Vlack et al, ), a factor that might contribute to the higher incidence of MRSA infections in similar populations.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of community‐associated methicillin‐resistant Staphylococcus aureus from pet dogs

Gemma

Worthing

Gottlieb

et al. 2019

Zoonoses and Public Health

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Community‐associated methicillin‐resistant Staphylococcus aureus (MRSA) is a serious public health concern and in Australia, one that disproportionately affects Aboriginal people. Paralleling MRSA in human medicine, methicillin‐resistant S. pseudintermedius (MRSP) is an increasingly prevalent pathogen in veterinary medicine. We aimed to characterize the carriage of MRSA and MRSP in dogs and cats from predominantly Aboriginal communities in a very remote region of New South Wales (NSW), Australia. Pets (303 dogs and 80 cats) were recruited from six communities in western NSW. Three swabs were collected from each animal (anterior nares, oropharynx and perineum) and from skin lesions or wounds (if present) and cultured on selective media for methicillin‐resistant staphylococci. Human host‐adapted community‐associated MRSA representing four multilocus sequence types (ST1‐IV, ST5‐IV, ST72‐IV, ST93‐IV) were isolated from eight dogs (prevalence 2.6%, 95% confidence interval 1.3%–5.1%). Two ST5‐IV isolates from a single dog were phenotypically trimethoprim‐resistant, harbouring trimethoprim‐resistant gene dfrG within the SCCmec type IVo mobile genetic element. MRSA was not isolated from any cats and MRSP was not isolated from any dogs or cats. This study estimated a high prevalence of human host‐adapted community‐associated MRSA carriage in dogs despite an absence of MRSP. This suggests MRSA carried by dogs in remote NSW originate from human hosts. The cycle of transmission between people, dogs and common environmental sources warrants further investigation. To our knowledge, this is the first report of trimethoprim‐resistant ST5‐IV in eastern Australia and the first report of trimethoprim‐resistant ST5‐IV from a dog.

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Infections and the diabetic foot

2017

Practical Diabetes Care

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Prevalence, risk factors and sequelae of Staphylococcus aureus carriage in diabetes: the Fremantle Diabetes Study Phase II

Cited by 23 publications

References 28 publications

Prevalence and characteristics of Staphylococcus aureus and methicillin‐resistant Staphylococcus aureus nasal colonization among a community‐based diabetes population in Foshan, China

Prevalence and characteristics of Staphylococcus aureus and methicillin‐resistant Staphylococcus aureus nasal colonization among a community‐based diabetes population in Foshan, China

Molecular characterization of community‐associated methicillin‐resistant Staphylococcus aureus from pet dogs

Infections and the diabetic foot

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