2018
DOI: 10.1097/md.0000000000011003
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Prevalence, risk factors, and prognosis of interstitial lung disease in a large cohort of Chinese primary Sjögren syndrome patients

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Cited by 64 publications
(71 citation statements)
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References 27 publications
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“…[5,7,14] In ILD in the context of autoimmune disorders, alterations to systemic in ammatory parameters like CRP have been frequently reported and also pose a risk factor for the development of pulmonary involvement in such conditions. [28,[34][35][36] Contrary to CRP, we found lactate dehydrogenase (LDH) signi cantly positively correlated with multiple non-in ammatory/ brotic as well as in ammatory HRCT nding scores. Elevations in LDH have been reported in IPF, where they may be associated with functional impairment and have prognostic properties.…”
Section: Discussioncontrasting
confidence: 59%
“…[5,7,14] In ILD in the context of autoimmune disorders, alterations to systemic in ammatory parameters like CRP have been frequently reported and also pose a risk factor for the development of pulmonary involvement in such conditions. [28,[34][35][36] Contrary to CRP, we found lactate dehydrogenase (LDH) signi cantly positively correlated with multiple non-in ammatory/ brotic as well as in ammatory HRCT nding scores. Elevations in LDH have been reported in IPF, where they may be associated with functional impairment and have prognostic properties.…”
Section: Discussioncontrasting
confidence: 59%
“…Chinese investigators retrospectively reviewed 1,341 hospitalized patients with SS (pSS, n ¼ 853; sSS, n ¼ 488). 202 ILD was present in 19.3% of patients with pSS and in 5.8% of patients with sSS. 202 Among those with lung involvement, 91.5% were women.…”
Section: Interstitial Lung Diseasementioning
confidence: 94%
“…Clinically significant ILD develops in 8 to 27% of subjects with pSS. 7,8,45,50,164,[198][199][200][201][202][203] Among patients with pSS, 10% had developed ILD by 1 year postdiagnosis and 20% by 5 years. 45 Compared with pSS patients without lung disease, pSS with lung involvement have a higher mortality rate 45,200 and poorer quality of life.…”
Section: Interstitial Lung Diseasementioning
confidence: 99%
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“…A nonspecific interstitial pneumonitis is the most common ILD in SS, 25,103,104 which can overlap with OP (see "Polymyositis/Dermatomyositis" section). 104 A UIP morphology is not uncommon.…”
Section: Parenchymal Diseasementioning
confidence: 99%