Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic Patients

Khalili, Shayesteh; Sabaghian, Tahereh; Sedaghat, Meghdad; Soroureddin, Zahra; Askari, Elham; Khalili, Neda

doi:10.1155/2021/6666086

Cited by 21 publications

(13 citation statements)

References 37 publications

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“…Among our study population, we observed an incidence of AKI of 25.8% similar to other reports [11,[22][23][24]. The reported rates of AKI are extremely variable; however, available evidence suggests that it likely affects >20% of hospitalized patients and >50% of patients in the ICU [25].…”

Section: Cumsupporting

confidence: 88%

“…On the basis of our multivariate logistic regression analysis; higher leukocytes, decreased eGFR and presence of proteinuria were independent predictors of AKI. As reported previously, we observed a high prevalence of hematuria and proteinuria in COVID-19 patients with AKI [3,12,19,21,22]. However, in a recent study, they found no significant differences in proteinuria, hematuria and leukocyturia among patients with AKI compared with non-AKI patients [24].…”

Section: Cumsupporting

confidence: 68%

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The value of urinalysis in predicting acute kidney injury and mortality in COVID-19 patients

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2021

Ukr. J. Nephrol. and Dial.

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Abstract. Kidney involvement is frequent among patients with coronavirus disease 2019 (COVID-19). However, kidney involvement is varied and mild kidney injury can easily go unnoticed. We aimed to investigate the urinalysis data of COVID-19 patients on admission and to explore the value of urinalysis in the prediction of acute kidney injury (AKI) and in-hospital mortality in patients with COVID-19. Methods. The demographic, clinical and laboratory data of patients with confirmed COVID-19 were retrospectively collected from the electronic health records of the hospital. The outcomes were the development of AKI and in-hospital mortality. Results. 244 patients were included in the analysis. The mean age was 59.6 ± 13.7 and 65.2% of patients were male. Serum creatinine on admission was 0.86 (0.72-1.05) mg/dL. Glucosuria, proteinuria and hematuria were found in 36.1%, 22.9% and 22.1% of patients, respectively. AKI was detected in 63 patients (25.8%) at any time of hospitalization. According to multivariate analysis, AKI development was associated with higher WBC and decreased eGFR as well as with proteinuria on admission. During median 8 (IQR, 5-12) days of follow-up, 33 patients (13.5%) died. Older age, higher C-reactive protein levels and proteinuria on admission were also independent predictors of in-hospital mortality. Conclusion. Proteinuria on admission was associated with the development of AKI and in-hospital mortality in patients with COVID-19. Urinalysis can be useful for early diagnosis of kidney damage before serum creatinine rise and mortality prediction in COVID-19 patients.

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Section: Cumsupporting

confidence: 88%

Section: Cumsupporting

confidence: 68%

The value of urinalysis in predicting acute kidney injury and mortality in COVID-19 patients

Oruç

Batırel

Trabulus

2021

Ukr. J. Nephrol. and Dial.

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“…These data are critical for understanding disease onset and progression. Identifying the potential risk factors for AKI in individuals with coexisting COVID-19 should help to guide therapeutic methods and, as a result, improve the prognosis of these patients [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Evolving Risk of Acute Kidney Injury in COVID-19 Hospitalized Patients: A Single Center Retrospective Study

et al. 2022

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Background and Objectives: Within a year, COVID-19 has advanced from an outbreak to a pandemic, spreading rapidly and globally with devastating impact. The pathophysiological link between COVID-19 and acute kidney injury (AKI) is currently being debated among scientists. While some studies have concluded that the mechanisms of AKI in COVID-19 patients are complex and not fully understood, others have claimed that AKI is a rare complication of COVID-19-related disorders. Considering this information gap and its possible influence on COVID-19-associated AKI management, our study aimed to explore the prevalence of AKI and to identify possible risk factors associated with AKI development among COVID-19 hospitalized patients. Materials and Methods: A retrospective cohort study included 83 laboratory-confirmed COVID-19 patients hospitalized at the isolation department in a tertiary hospital in Zagazig City, Egypt between June and August 2020. Patients younger than 18 years of age, those diagnosed with end-stage kidney disease, or those on nephrotoxic medications were excluded. All study participants had a complete blood count, liver and renal function tests, hemostasis parameters examined, inflammatory markers, serum electrolytes, routine urinalysis, arterial blood gas, and non-enhanced chest and abdominal computer tomography (CT) scans. Results: Of the 83 patients, AKI developed in 24 (28.9%) of them, of which 70.8% were in stage 1, 8.3% in stage 2, and 20.8% in stage 3. Patients with AKI were older than patients without AKI, with hypertension and diabetes being the most common comorbidities. Risk factors for AKI include increased age, hypertension, diabetes mellitus, and a higher sequential organ failure assessment (SOFA) score. Conclusions: AKI occurs in a considerable percentage of patients with COVID-19, especially in elderly males, those with hypertension, diabetes, and a higher sequential organ failure assessment (SOFA) score. Hence, the presence of AKI should be taken into account as an important index within the risk spectrum of disease severity for COVID-19 patients.

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“…In present study, DM came out to be a significant risk factor for developing AKI as reported by other studies. 10,13,15 In a study by Khalili et al 18 , amongst hospitalized COVID-19 patients, AKI developed more in diabetics as compared to non-diabetics (62% vs. 38%). Hyperglycemia, suppressed immunity, thromboembolic events and sepsis/septic shock are important pathogenic mechanisms involved in causing AKI in DM.…”

Section: A H E a D O F P R I N Tmentioning

confidence: 99%

The Frequency and Risk Factors for Acute Kidney Injury in patients with COVID-19

et al. 2022

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Objective: To determine the frequency of Acute Kidney Injury (AKI) and its underlying risk factors in patients with Coronavirus Disease (COVID-19). Methods: This retrospective study was conducted by reviewing the medical records of patients admitted in Covid-19 Intensive Care Unit (ICU) of Farooq Hospital, West Wood Branch, Lahore during the period from 1st April, 2020 to 30th June, 2020. COVID-19 was diagnosed on basis of Real Time Polymerase Chain Reaction (RT-PCR) through nasal swab. Demographic, clinical and laboratory data were collected at the time of admission in the hospital. AKI was diagnosed on basis of ≥ 0.3 mg/dl increase in serum Creatinine (sCr) from baseline during the hospital stay. The outcome of study was AKI. Results: One hundred and seventy-six patients who fulfilled the inclusion criteria were recruited of which most were males (78.4%). The mean age was 51.26 ± 15.20 years and the frequency of AKI was 51.1%. The risk factors for AKI were increasing age (OR=2.10, p=0.017); presence of COVID-19 symptoms (OR=6.62, p=0.004); prolonged hospital stay (OR=2.26, p=0.011); Diabetes Mellitus (OR=1.81, p=0.057); hypoxemia (OR=5.98, p=0.000); leukocytosis (OR=2.91, p=0.002); lymphopenia (OR=5.77, p=0.000); hypoalbuminemia (OR=4.94, p=0.000); elevated C-reactive protein (CRP) (OR=6.20, p=0.000) and raised D-diamers (OR=3.16, p=0.000). Conclusions: AKI was present in half of the COVID-19 patients. The most significant risk factors for AKI were increasing age, prolonged hospital stay, hypoxemia, hypoalbuminemia, DM and raised inflammatory markers. doi: https://doi.org/10.12669/pjms.38.4.4980 How to cite this:Anees M, Farooq O, Raza M, Mumtaz A. Frequency and Risk Factors for Acute Kidney Injury in patients with COVID-19. Pak J Med Sci. 2022;38(4):---------. doi: https://doi.org/10.12669/pjms.38.4.4980 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic Patients

Cited by 21 publications

References 37 publications

The value of urinalysis in predicting acute kidney injury and mortality in COVID-19 patients

The value of urinalysis in predicting acute kidney injury and mortality in COVID-19 patients

Evolving Risk of Acute Kidney Injury in COVID-19 Hospitalized Patients: A Single Center Retrospective Study

The Frequency and Risk Factors for Acute Kidney Injury in patients with COVID-19

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