Prevalence, Risk Factors, and Mortality for Ventilator-Associated Pneumonia in Middle-Aged, Old, and Very Old Critically Ill Patients*

Blot, Stijn; Koulenti, Despoina; Dimοpoulos, George; Martin, Claude; Komnos, Apostolos; Krueger, Wolfgang A.; Spina, G; Armaganidis, Apostolos; Rello, Jordi

doi:10.1097/01.ccm.0000435665.07446.50

Cited by 150 publications

(131 citation statements)

References 42 publications

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“…[26] Our study also supports the observation that elderly population are at more risk of death due to VAP i.e. 55% in our study [27] [ Table 5]. Comorbidities have significant effect in the onset of VAP and mortality.…”

Section: Discussionsupporting

confidence: 80%

Ventilator Associated Pneumonia - Clinical Profile, Comorbidities and Prognosis

Sudulagunta¹,

L²,

Raja³

et al. 2016

jemds

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Section: Discussionsupporting

confidence: 80%

Ventilator Associated Pneumonia - Clinical Profile, Comorbidities and Prognosis

Sudulagunta¹,

L²,

Raja³

et al. 2016

jemds

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“…This result indicates that mortality and clinical and microbiological resolutions were strongly correlated with severity of the patients at the initial phase of pneumonia [31–33]. …”

Section: Discussionmentioning

confidence: 99%

Pseudomonas aeruginosa serotypes in nosocomial pneumonia: prevalence and clinical outcomes

et al. 2014

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IntroductionPseudomonas aeruginosa frequently causes nosocomial pneumonia and is associated with poor outcome. The purpose of this study was to assess the prevalence and clinical outcome of nosocomial pneumonia caused by serotype-specific P. aeruginosa in critically ill patients under appropriate antimicrobial therapy management.MethodsA retrospective, non-interventional epidemiological multicenter cohort study involving 143 patients with confirmed nosocomial pneumonia caused by P. aeruginosa. Patients were analyzed for a period of 30 days from time of nosocomial pneumonia onset. Fourteen patients fulfilling the same criteria from a phase IIa studyconducted at the same time/centers were included in the prevalence calculations but not in the clinical outcome analysis.ResultsThe prevalence of serotypes was: O6 (29%), O11 (23%), O10 (10%), O2 (9%), and O1 (8%). Serotypes with a prevalence of less than 5% were found in 13% of patients, 8% were classified as not typeable. Across all serotypes, 19% mortality, 70% clinical resolution, 11% clinical continuation, and 5% clinical recurrence were recorded. Age and higher APACHE II (Acute Physiology and Chronic Health Evaluation II) were predictive risk factors associated with probability of death and lower clinical resolution for P. aeruginosa nosocomial pneumonia. Mortality tends to be higher with O1 (40%) and lower with O2 (0%); clinical resolution tends to be better with O2 (82%) compared to other serotypes. Persisting pneumonia with O6 and O11 was, respectively, 8% and 21%; clinical resolution with O6 and O11 was, respectively, 75% and 57%.ConclusionsIn P. aeruginosa nosocomial pneumonia, the most prevalent serotypes were O6 and O11. Further studies including larger group sizes are needed to correlate clinical outcome with virulence factors of P. aeruginosa in patients with nosocomial pneumonia caused by various serotypes; and to compare O6 and O11, the two serotypes most frequently encountered in critically ill patients.

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“…Letter to the Editor Prevention of ventilator-associated pneumonia (VAP) remains a main objective in infection control in intensive care units (ICUs) [1,2] as VAP is associated with significant morbidity and possibly mortality in critically ill patients [3][4][5]. Maintaining or improving oral hygiene by means of an oral care protocol is an essential part of the comprehensive approach needed to reduce VAP risk and in this regard the use of mouth rinses with an antiseptic agent is considered pivotal.…”

Section: Accepted Manuscriptmentioning

confidence: 99%