Prevalence, risk factors, and impact of lung cancer on outcomes of idiopathic pulmonary fibrosis: a study from the Middle East

Salim, Mohamed; Bayoumi, Hassan; El‐Aziz, Nashwa Abd; Mousa, Ehab; Gamal, Yasser

doi:10.4081/mrm.2018.191

Cited by 6 publications

(8 citation statements)

References 14 publications

(60 reference statements)

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“…The incidence of LC in patients who had been hospitalized with pneumonia was significantly higher than in the general population [28]. This is expected to be more challenging in patients with LC-IPF [2], particularly those who receive chemo-or radiotherapy for their disease [2,4]. The use of sensitive biomarkers, like PCT, could be helpful in that situation.…”

Section: Discussionmentioning

confidence: 99%

“…A systematic search of the patient database at the chest department of AUH revealed that 152 patients fulfilled the international guidelines on the diagnosis and management of IPF [1] during the period of August 1, 2014, to August 31, 2019. Among these 152 patients, we randomly selected 137 patients diagnosed with IPF who were then followed up regularly at our department according to a prospective protocol for the follow-up of IPF patients, as shown previously [2]. The remaining 15 patients were excluded due to incomplete follow-up data.…”

Section: Study Design and Populationmentioning

confidence: 99%

“…Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias and carries the worst prognosis [ 1 ]. Despite the fact that several clinicopathologic and radiographic variables have been shown to correlate with survival in patients with IPF [ 2 ], the development of lung cancer (LC) among those patients, which ranges from 4.8 to 48% [ 2 - 4 ], further worsens their prognosis [ 2 , 5 ]. Procalcitonin (PCT) is the prohormone of calcitonin and is thought to be mainly produced in the liver by macrophages (Kupffer cells) or neuroendocrine (NE) cells [ 6 - 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Serum Procalcitonin in Patients With Combined Lung Cancer and Idiopathic Pulmonary Fibrosis (LC-IPF)

Salim

Abdelhaffez

El‐Aziz

2020

Cureus

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Background Procalcitonin (PCT) is a potential biomarker for sepsis and acts as a guide to antibiotic administration. Previous studies showed that lung cancer (LC) may increase serum PCT levels. However, no studies addressed serum PCT in patients with combined LC and idiopathic pulmonary fibrosis (IPF): LC-IPF. We aimed to evaluate the significance of serum PCT in patients with LC-IPF. Methods A total of 137 patients with IPF who had complete follow-up data were reviewed. They were categorized into two groups: 30 patients with LC and IPF (LC-IPF) and 82 patients with IPF only (IPF). PCT assays in the two groups were done using the enzyme-linked immunosorbent assay (ELISA) technique. Results Median serum PCT (IQR) was significantly higher in patients with LC-IPF in comparison to those with IPF only (0.655± 3.60 vs 0.07 ± 0.11 ng/ml, p=0.016), respectively. LC-IPF patients with neuroendocrine (NE) component, stage IV disease, and with >2 metastatic sites had a significantly higher PCT in comparison to those with non-NE, stages I-III, and <2 metastatic sites, respectively. The presence of the NE component was the only independent risk factor predictive for PCT positivity in patients with LC-IPF; OR1.8 (95% confidence interval (CI) 0.042-2.145; p = 0.042). Conclusion Patients with LC-IPF have higher serum PCT levels than those with IPF alone. These levels are related to the presence of NE component, advanced cancer stage, and the presence of multiple metastases. The presence of the NE component is the only independent risk factor predictive for PCT positivity in patients with LC-IPF. Further studies are warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Study Design and Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum Procalcitonin in Patients With Combined Lung Cancer and Idiopathic Pulmonary Fibrosis (LC-IPF)

Salim

Abdelhaffez

El‐Aziz

2020

Cureus

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“…In China, LC also has high incidence and mortality, and men's morbidity and mortality are more than twice than that of women (6). Most studies suggested that the occurrence of LC is related to environmental (smoke, occupational exposure, and air pollution) and genetic factors (7,8), especially genetic factors play important role. Li et al (9) revealed that LC susceptibility in Chinese Han population is related to HOTAIR gene mutation.…”

Section: Introductionmentioning

confidence: 99%

Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer in a Chinese Han population

Duan

Liu

Niu³

et al. 2020

Preprint

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Background The aim of this study was to investigate the effects of COL6A4P2 polymorphisms on lung cancer (LC) in Chinese Han population.Methods To examine whether variants of COL6A4P2 contribute to LC, five single nucleotide polymorphisms (SNPs) of COL6A4P2 were genotyped by Agena MassARRAY in 510 LC patients and 495 controls. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression.Results We found that COL6A4P2 rs34445363 significantly increased the risk of LC in the alleles model (OR = 1.26, 95%CI: 1.01 - 1.58, p = 0.038). And rs34445363 also increased the LC risk under the log-additive model (OR = 1.26, 95%CI: 1.01 - 1.58, p = 0.041) with the multigene model analysis. Further stratification analysis showed that rs34445363 increased the LC risk under the log-additive model (OR = 1.42, 95%CI: 1.03 - 1.95, p = 0.033) in people aged ≤ 61; and rs61733464 was associated with a decreased LC risk in the log-additive model (OR = 0.72, 95%CI: 0.52 - 0.99, p = 0.048) in people aged ≤ 61. We also found that the mutations of rs34445363 and rs77941834 were associated with increased LC risk in the codominant model (rs34445363, GA vs. GG, OR = 1.73, 95%CI: 1.04 - 2.86, p = 0.034; rs77941834, TA vs. TT, OR = 1.88, 95%CI: 1.06 - 3.34, p = 0.032) in females.Conclusions This study provided an evidence for polymorphisms of COL6A4P2 gene associated to the development of LC, also a new insight into etiology of LC.

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“…At present, surgery is still the treatment of choice for early stage lung cancer, most lung cancer patients have been diagnosed at an advanced stage, lost the best treatment opportunity, and its 5-year survival rate is only 19.7% [1,3]. Most studies suggested that the occurrence of Lung cancer is related to environmental, such as smoking, occupational exposure, and air pollution [4,5]. At the same, genetic factors play an important role in the development of lung cancer, including EGFR [6], CHRNA5 [7], CLPTM1L [8], TP63 [9], and so on.…”

Section: Introductionmentioning

confidence: 99%

Impact of GTF2H1 and RAD54L2 gene polymorphisms on the non-small cell lung cancer with Platinum chemotherapy in high altitude areas

Li¹,

Chen²,

Ji³

et al. 2019

Preprint

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Background Repair pathway genes are closely related to the sensitivity of tumor patients to drugs. It is particularly important to study the correlation between non-small cell lung cancer (NSCLC) and DNA repair gene (GTF2H1 and RAD54L2) in high altitude areas.Materials and methods Four SNPs on RAD54L2 and five SNPs on GTF2H1 were genotyped via the Agena MassARRAY in 506 age-and gender-matched patients with NSCLC and 510 healthy controls. The influence of GTF2H1 and RAD54L2 on lung cancer was assessed by logistic regression analysis. The effects of polymorphisms of these two genes on the efficacy and side effects of NSCLC patients with platinum-based chemotherapy were further evaluated.Results RAD54L2 rs9864693 GC heterozygote genotype was increased the risk of NSCLC (OR = 1.33, 95%CI: 1.01 – 1.77, p = 0.045). Stratified analysis found that GTF2H1 rs4150667 promoted the risk of lung cancer in individuals younger than 59 years group (OR = 1.32, 95%CI: 1.00 – 1.75, p = 0.048). However, the individuals with GTF2H1 rs3802967 CT-TT reduced the risk of the lung squamous cell carcinoma by 32% (OR = 0.68, 95%CI: 0.46 – 0.99, p = 0.045). The patients with GTF2H1 rs3802967 TT genotypes showed a significantly higher curative effect (OR = 2.65, 95%CI: 1.14 - 6.15, p = 0.023); patients with GTF2H1 rs3802967 TT genotypes showed a significantly lower risk of side effects (OR = 0.32, 95%CI: 0.10 - 0.98, p = 0.047).Conclusion Our study indicated that RAD54L2 and GTF2H1 gene was associated with NSCLC susceptibility.

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Prevalence, risk factors, and impact of lung cancer on outcomes of idiopathic pulmonary fibrosis: a study from the Middle East

Cited by 6 publications

References 14 publications

Serum Procalcitonin in Patients With Combined Lung Cancer and Idiopathic Pulmonary Fibrosis (LC-IPF)

Serum Procalcitonin in Patients With Combined Lung Cancer and Idiopathic Pulmonary Fibrosis (LC-IPF)

Impact of COL6A4P2 gene polymorphisms on the risk of lung cancer in a Chinese Han population

Impact of GTF2H1 and RAD54L2 gene polymorphisms on the non-small cell lung cancer with Platinum chemotherapy in high altitude areas

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