Prevalence patterns of gastric cancers in Turkey: Model of a developing country with high occurrence of Helicobacter pylori

Abstract

In Turkey, a developing country with a high H. pylori prevalence, contrary to the state of developed countries, the ratio of distal versus proximal gastric adenocarcinomas has not changed. Geographical distribution should be taken into the account in projecting the changing patterns of gastric cancers.

Alteration in Methylation Pattern of Retinoblastoma 1 Gene Promotor Region in Intestinal Metaplasia with or without Helicobacter pylori and Gastric Cancer Patients

“…In the national studies carried out in Turkey, male/female ratio was also defined as similar to this ratio [15]. In this study, male/female ratio (n = 15/n = 9) was found to be 1.67, which correlates with the data from the world and Turkish studies [16].…”

Usefulness of Serum Pepsinogen Levels as a Screening Test For Atrophic Gastritis and Gastric Cancer

“…The single use of pepsinogen tests is by no means sufficient for stomach cancer screening; however, it provides a valuable measure for selecting a population that needs further screening with endoscopy [12][13][14][15]. Serum pepsinogen was introduced for cancer screening to identify individuals with extensive atrophic gastritis [16].…”

Aurora kinase A (AURKA) and never in mitosis gene A-related kinase 6 (NEK6) genes are upregulated in erosive esophagitis and esophageal adenocarcinoma

“…The incidence of EAC has increased faster than that of any malignancy in Western countries, with an increase of 400% over the past 40 years (2). However, there has been no increase in the prevalence of proximal gastric cancers and distal esophageal adenocarcinomas in the Turkish population (3). The prognosis for EAC is poor and the overall 5-year survival rate is less than 10% (4).…”