Prevalence of Voice Disorders in Iranian Primary School Students

Mohammadzadeh, Ali; Sandoughdar, N

doi:10.1016/j.jvoice.2016.04.004

Cited by 24 publications

(6 citation statements)

References 23 publications

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“…The development of voice disorders is identified as an occupational hazard, particularly among speakers who depend on a healthy voice for their livelihood. School teachers, entertainers, legal professionals are all at greater risk of dysphonia from voice disorders [ 3 , 7 , 10 – 13 ]. The economic impact of voice disorders is substantial.…”

Section: Introductionmentioning

confidence: 99%

RNA sequencing identifies transcriptional changes in the rabbit larynx in response to low humidity challenge

et al. 2020

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Background Voice disorders are a worldwide problem impacting human health, particularly for occupational voice users. Avoidance of surface dehydration is commonly prescribed as a protective factor against the development of dysphonia. The available literature inconclusively supports this practice and a biological mechanism for how surface dehydration of the laryngeal tissue affects voice has not been described. In this study, we used an in vivo male New Zealand white rabbit model to elucidate biological changes based on gene expression within the vocal folds from surface dehydration. Surface dehydration was induced by exposure to low humidity air (18.6% + 4.3%) for 8 h. Exposure to moderate humidity (43.0% + 4.3%) served as the control condition. Ilumina-based RNA sequencing was performed and used for transcriptome analysis with validation by RT-qPCR. Results There were 103 statistically significant differentially expressed genes identified through Cuffdiff with 61 genes meeting significance by both false discovery rate and fold change. Functional annotation enrichment and predicted protein interaction mapping showed enrichment of various loci, including cellular stress and inflammatory response, ciliary function, and keratinocyte development. Eight genes were selected for RT-qPCR validation. Matrix metalloproteinase 12 (MMP12) and macrophage cationic peptide 1 (MCP1) were significantly upregulated and an epithelial chloride channel protein (ECCP) was significantly downregulated after surface dehydration by RNA-Seq and RT-qPCR. Suprabasin (SPBN) and zinc activated cationic channel (ZACN) were marginally, but non-significantly down- and upregulated as evidenced by RT-qPCR, respectively. Conclusions The data together support the notion that surface dehydration induces physiological changes in the vocal folds and justifies targeted analysis to further explore the underlying biology of compensatory fluid/ion flux and inflammatory mediators in response to airway surface dehydration.

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Section: Introductionmentioning

confidence: 99%

RNA sequencing identifies transcriptional changes in the rabbit larynx in response to low humidity challenge

et al. 2020

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“…Prevalence of pediatric dysphonia was found to be highly variable across studies. It was reported to range from 2% to 23.9% in the United states [1-3] and could go as high as 53.2% in an Iranian population [4]. In Hong Kong, the prevalence of dysphonia in school-age children was reported to be 5.4% [5].…”

Section: Introductionmentioning

confidence: 99%

Cross-cultural Adaptation and Validation of the Hong Kong-Chinese version of Children's Voice Handicap Index-10 for Parents (CVHI-10-P(HK))

Kwong

2023

Journal of Voice

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“…Voice disorders are a prevalent communication disorder affecting human health worldwide (1)(2)(3)(4)(5)(6). In the United States general population, the prevalence of voice disorders has been estimated at 6.2% (7), and more recently, at 7.6% (8).…”

Section: Introductionmentioning

confidence: 99%

“…The development of voice disorders is identi ed as an occupational hazard, particularly among speakers who depend on a healthy voice for their livelihood. School teachers, entertainers, legal professionals are all at greater risk of dysphonia from voice disorders (3,7,(10)(11)(12)(13). average associated health care costs in the United States have been estimated at almost 200 million dollars (14), and a study of Brazilian teachers having to take time away from work due to dysphonia illustrates the potential impact of a loss of productivity in the workforce (15).…”

Section: Introductionmentioning

confidence: 99%

RNA sequencing identifies transcriptional changes in the rabbit larynx in response to low humidity challenge

Bailey

Santos

Nascimento

et al. 2020

Preprint

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Background: Voice disorders are a worldwide problem impacting human health, particularly for occupational voice users. Avoidance of surface dehydration is commonly prescribed as a protective factor against the development of dysphonia. The available literature inconclusively supports this practice and a biological mechanism for how surface dehydration of the laryngeal tissue affects voice has not been described. In this study, we used an in vivo male New Zealand white rabbit model to elucidate biological changes based on gene expression within the vocal folds from surface dehydration. Surface dehydration was induced by exposure to low humidity air (18.6% + 4.3%) for 8 hours. Exposure to moderate humidity (43.0% + 4.3%) served as the control condition. Ilumina-based RNA sequencing was performed and used for transcriptome analysis with validation by RT-qPCR. Results: There were 103 statistically significant differentially expressed genes identified through Cuffdiff with 61 genes meeting significance by both false discovery rate and fold change. Functional annotation enrichment and predicted protein interaction mapping showed enrichment of various loci, including cellular stress and inflammatory response, ciliary function, and keratinocyte development. Eight genes were selected for RT-qPCR validation. Matrix metalloproteinase 12 (MMP12) and macrophage cationic peptide 1 (MCP1) were significantly upregulated and an epithelial chloride channel protein (ECCP) was significantly downregulated after surface dehydration by RNA-Seq and RT-qPCR. Suprabasin (SPBN) and zinc activated cationic channel (ZACN) were marginally, but non-significantly down- and upregulated as evidenced by RT-qPCR, respectively. Conclusions: The data together support the notion that surface dehydration induces physiological changes in the vocal folds and justifies targeted analysis to further explore the underlying biology of compensatory fluid/ion flux and inflammatory mediators in response to airway surface dehydration.

show abstract

Prevalence of Voice Disorders in Iranian Primary School Students

Cited by 24 publications

References 23 publications

RNA sequencing identifies transcriptional changes in the rabbit larynx in response to low humidity challenge

RNA sequencing identifies transcriptional changes in the rabbit larynx in response to low humidity challenge

Cross-cultural Adaptation and Validation of the Hong Kong-Chinese version of Children's Voice Handicap Index-10 for Parents (CVHI-10-P(HK))

RNA sequencing identifies transcriptional changes in the rabbit larynx in response to low humidity challenge

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