Prevalence of vitamin D insufficiency in elderly ambulatory outpatients in Denver, Colorado

Linnebur, Sunny A.; Vondracek, Sheryl F.; Griend, Joseph P. Vande; Ruscin, J. Mark; McDermott, Michael T.

doi:10.1016/j.amjopharm.2007.03.005

Cited by 41 publications

(30 citation statements)

References 20 publications

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“…Our results, as well as those from Oliveri et al [21], Portela [18], and Linnebur [22], demonstrate a strong correlation between female sex and vitamin D deficiency. These results could be explained by the variations in hormone secretion between the sexes, an association that merits exploration in future research.…”

Section: Discussionsupporting

confidence: 90%

Vitamin D deficiency in older adults and its associated factors: a cross-sectional analysis of the Mexican Health and Aging Study

et al. 2016

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Summary Vitamin D deficiency was common in older adults from a country with adequate sun exposure. The variables associated with this deficiency provide insight into the next steps needed to characterize older adults with this deficiency and to treat it accordingly. Purpose The aim of this study was to describe the prevalence of and factors associated with vitamin D deficiency among Mexican older adults. Methods This was a secondary analysis of the last wave of the Mexican Health and Aging Study. Vitamin D levels along with other biomarkers were obtained from a sub-sample of Mexican adults older than 60 years. Prevalence was described by sex and age group, and a multivariate analysis was performed to test the factors associated with this condition. Results Data from 1088 adults over the age of 60 years were analyzed. The mean serum vitamin D level was 23.1 ± 8.1 ng/mL and was significantly higher among men than women (25.6 ± 0.6 and 22.8 ± 0.5 ng/mL, respectively; p < 0.001). In total, 37.3% (n = 406) presented with vitamin D deficiency, 65% of whom were women. Low 25-(OH)-vitamin D levels were associated with female sex (OR 1.74, 95% CI 1.59–2.42), current smoking (OR 2.21, 95% CI 1.47–3.39), education (OR 1.1, 95% CI 1.06–1.13), physical activity (OR 1.74, 95% CI 1.31–2.23), and high levels of glycated hemoglobin (OR 1.16, 95% CI 1.07–1.25). Conclusions Vitamin D deficiency was highly prevalent in Mexican older adults and was associated with a number of factors, indicating the multifactorial causality of this deficiency.

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Section: Discussionsupporting

confidence: 90%

Vitamin D deficiency in older adults and its associated factors: a cross-sectional analysis of the Mexican Health and Aging Study

et al. 2016

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“…The high prevalence of hypovitaminosis D, estimated by serum 25(OH)D found in our population, reflects the data available in literature [36] in elderly subjects. This finding is consistent with the evidence of the antiinflammatory properties of 25(OH)D, and with the results of several studies demonstrating how vitamin D levels are correlated inversely with the extent of coronary artery calcification [37], and directly with coronary heart disease [38] and stroke [39].…”

Section: Discussionsupporting

confidence: 80%

Carotid intima-media thickness and bone turnover: the role of C-terminal telopeptide of type I collagen

et al. 2010

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Osteoporosis and vascular disease are commonly found together in elderly people. Several common mechanisms and risk factors have been suggested to contribute to the development of osteoporosis and atherosclerosis. The present cross-sectional study was performed to determine whether the degree of bone turnover is correlated to carotid intima-media thickness (CCA-IMT), as a marker of subclinical atherosclerosis. We selected 50 outpatients (mean age 71.7 +/- 12.3), underwent to eco-Doppler evaluation of extracranial carotid tract, without history of calcium and/or vitamin D supplementation, or antireabsorptive therapy. CCA-IMT was measured by high-resolution B-mode ultrasonography. Bone turnover was evaluated by analysing serum levels of C-terminal telopeptide of type I collagen (sCTX), and bone-specific alkaline phosphatase. We also evaluated the vitamin D status by determination of the serum concentration of 25-hydroxyvitamin D [25(OH)D]. We found a prevalence of hypovitaminosis D [serum 25(OH)D levels <30 ng/mL, mean value 10.7 +/- 5.8] of 91.8%, and an increased bone resorption, with mean sCTX levels higher than reference values (mean 1.18 +/- 0.57 ng/mL). A significant positive correlation was found between CCA-IMT and age (r = 0.480, P = 0.001), erythrocyte sedimentation rate (ESR: r = 0.438, P = 0.001), high-sensitivity C-Reactive Protein (HsCRP: r = 0.482, P = 0.011), serum creatinine (r = 0.305, P = 0.031), and sCTX (r = 0.389, P = 0.006). In a multivariate linear regression, CCA-IMT was independently predicted by age (beta = 0.34, P = 0.001), ESR (beta = 0.37, P = 0.005), and sCTX (beta = 0.32, P = 0.006). The preliminary results of our study seem to indicate that after adjustment for established cardiovascular risk factors, sCTX independently predict an increased CCA-IMT in the elderly population.

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“…[1][2][3][4][5][6][7][8][9][10] Some have proposed that increased body fat is associated with lower 25(OH)D levels because 25(OH)D accumulates in fat or because of lifestyle differences between obese and nonobese populations. 11,12 However, our longitudinal data in older women gaining weight are consistent with the hypothesis that low 25(OH)D levels could actually predispose to fat accumulation.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10] Although this association has been attributed to increased storage of 25(OH)D in fat tissue or potential lifestyle differences between obese and nonobese populations, 11,12 evidence from epidemiologic, [1][2][3][4][5][6][7][8][9][10] weight loss, [13][14][15][16][17] and in vitro/ animal studies [18][19][20][21][22][23][24] suggests that 25(OH)D might be involved in weight regulation. Vitamin D receptors (VDR) are present on human adipocytes.…”

mentioning

confidence: 99%

Associations Between 25-Hydroxyvitamin D and Weight Gain in Elderly Women

LeBlanc

Rizzo

Pedula

et al. 2012

Journal of Women's Health

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Results: Women with 25(OH)D levels ‡ 30 ng/mL had lower baseline weight (141.6 pounds) compared to women with 25(OH)D levels < 30 ng/mL (148.6 pounds) ( p < 0.001). Overall, 25(OH)D status was not associated with weight change over 4.5 years, although there was a significant interaction between 25(OH)D status and weight change category (loss, gain, stable) ( p < 0.0001). In women who gained ‡ 5% weight, those with baseline 25(OH)D levels ‡ 30 ng/mL gained 16.4 pounds (12.2% of baseline weight) over 4.5 years compared to 18.5 pounds (13.9% of baseline weight) in women with levels < 30 ng/mL ( p = 0.04). In women who lost ‡ 5% weight or remained stable ( < 5% weight change), there was no association between 25(OH)D status at baseline and weight change. Among women who gained weight and had 25(OH)D measured at both visits, having sustained or developing 25(OH)D levels ‡ 30 ng/mL was associated with less weight gain between visits (14.81 vs. 16.34 pounds, p = 0.04). Conclusions: Higher 25(OH)D levels are associated with lower weight gains, suggesting low vitamin D status may predispose to fat accumulation.

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Prevalence of vitamin D insufficiency in elderly ambulatory outpatients in Denver, Colorado

Cited by 41 publications

References 20 publications

Vitamin D deficiency in older adults and its associated factors: a cross-sectional analysis of the Mexican Health and Aging Study

Vitamin D deficiency in older adults and its associated factors: a cross-sectional analysis of the Mexican Health and Aging Study

Carotid intima-media thickness and bone turnover: the role of C-terminal telopeptide of type I collagen

Associations Between 25-Hydroxyvitamin D and Weight Gain in Elderly Women

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