Prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome and its association with metabolic syndrome – A prospective observational study

Mogili, Krishna Deepti; Karuppusami, Reka; Thomas, Sumi; Chandy, Achamma; Kamath, Mohan S; Tk, Aleyamma

doi:10.1016/j.ejogrb.2018.08.001

“…Furthermore, poor exposure to sunlight, and insufficient dietary consumption of vitamin D may have also contributed to these results. The study has shown that PCOS women have lower vitamin D levels than non-PCOS women, which is in agreement with the studies of Hamdi et al, and Mogili et al (27,28). Vitamin D related polymorphisms could be the cause of its deficiency in PCOS (21).…”

Section: Methodssupporting

confidence: 91%

Level of follicular fluid vitamin D and embryo quality in a sample of Iraqi women undergoing IVF

Alawad

¹

2019

JFacMedBagdad

4

0

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Background: Vitamin D has been linked to fertility since its receptors were found in reproductive organs. Nevertheless, its exact role in fertility is yet to be cleared. Objectives: To analyze follicular fluid (FF) vitamin D in females doing Intracytoplasmic Sperm Injection (ICSI), to compare its level between Polycystic Ovary Syndrome (PCOS) and non-PCOS females, and to explore whether vitamin D correlates with oocytes number, percentage of oocyte maturity, fertilization rate and percentage of high quality embryos. Patients and methods: This comparative observational study was done, from January to October 2018, at Al Amal IVF Center, Jenin hospital, Baghdad. The study was conducted on 40 women; 18 had PCOS, 15 had blocked fallopian tubes and 7 had idiopathic infertility. FF vitamin D was analyzed by Ichroma kit, Boditech. Deficient, insufficient, and sufficient vitamin D levels were as: <10, 10-29, and 30-100 ng/ml, respectively. Results: Most participants were deficient (12 women) or insufficient (18 women) of vitamin D, only 10 women had adequate vitamin D levels. FF vitamin D was higher in non-PCOS than PCOS women (P= 0.011). The correlation between vitamin D and oocytes number was not significant. However, it was significant with percentage of oocyte maturity (rho= 0.459, P= 0.003), fertilization rate (rho= 0.471, P= 0.002) and percentage of high quality embryos (rho= 0.316, P= 0.047). Conclusions: PCOS patients, when compared to non-PCOS, have lower vitamin D levels. FF vitamin D might correlate with percentage of oocyte maturity, fertilization rate and percentage of high quality embryos in patients undergoing ICSI.

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“…Furthermore, poor exposure to sunlight, and insufficient dietary consumption of vitamin D may have also contributed to these results. The study has shown that PCOS women have lower vitamin D levels than non-PCOS women, which is in agreement with the studies of Hamdi et al, and Mogili et al (27,28). Vitamin D related polymorphisms could be the cause of its deficiency in PCOS (21).…”

Section: Methodssupporting

confidence: 91%

Level of follicular fluid vitamin D and embryo quality in a sample of Iraqi women undergoing IVF

Alawad

¹

2019

J. Fac. Med Baghdad

0

View full text Add to dashboard Cite

Background: Vitamin D has been linked to fertility since its receptors were found in reproductive organs. Nevertheless, its exact role in fertility is yet to be cleared. Objectives: To analyze follicular fluid (FF) vitamin D in females doing Intracytoplasmic Sperm Injection (ICSI), to compare its level between Polycystic Ovary Syndrome (PCOS) and non-PCOS females, and to explore whether vitamin D correlates with oocytes number, percentage of oocyte maturity, fertilization rate and percentage of high quality embryos.

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“…Several underlying mechanisms have been identified, ranging from vitamin D deficiency (VDD) to oxidative stress. VDD can be identified in 70-80% of PCOS women [ 4 , 5 ]. VDD itself is associated with various morbidities including metabolic syndrome, obesity, and cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D Status on Vascular Function of the Aorta in a Rat Model of PCOS

Lajtai

¹

,

Tarszabó

²

,

Bányai³

et al. 2021

Oxidative Medicine and Cellular Longevity

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Polycystic ovary syndrome (PCOS) is associated with elevated cardiovascular risk. Early vascular dysfunction may lead to the development of cardiovascular disease in PCOS. Vitamin D deficiency (VDD) is a common comorbidity of PCOS that contributes to the pathogenesis of the disease and its complications. Both PCOS and VDD are accompanied by increased oxidative stress that may be involved in the arising vascular dysfunction. We aimed to investigate the role of vitamin D status on aortic function. PCOS was induced by an 8-week-long transdermal testosterone treatment of female rats, and low and adequate vitamin D status was achieved by dietary means. Contraction and relaxation abilities of isolated aortic segments were measured by myograph. Resorcin-fuchsin staining and immunohistochemical labeling of 3-nitrotyrosine were performed. No difference was shown in the norepinephrine-induced contraction of the aortas of different groups, whereas we detected reduced acetylcholine- and insulin-evoked relaxation in VDD groups. A lower level of resorcin-fuchsin staining and elevated 3-nitrotyrosine immunostaining was observed in VDD. In our study, we demonstrated early endothelial dysfunction in VDD PCOS rat model. Vitamin D supplementation could prevent vascular disturbances, while VDD itself damaged endothelium-dependent vasorelaxation and induced nitrative stress.

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Prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome and its association with metabolic syndrome – A prospective observational study

Cited by 33 publications

References 32 publications

Level of follicular fluid vitamin D and embryo quality in a sample of Iraqi women undergoing IVF

Level of follicular fluid vitamin D and embryo quality in a sample of Iraqi women undergoing IVF

Level of follicular fluid vitamin D and embryo quality in a sample of Iraqi women undergoing IVF

Effect of Vitamin D Status on Vascular Function of the Aorta in a Rat Model of PCOS

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