Prevalence of vitamin D deficiency and insufficiency among 460,537 children in 825 hospitals from 18 provinces in mainland China

Yang, Chunsong; Mao, Meng; Li, Ping; Yu, Dan

doi:10.1097/md.0000000000022463

Cited by 20 publications

(20 citation statements)

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“…[8,21] A cohort study of neonates performed by Kanike et al [22] reported a high prevalence of vitamin D deficiency (31%) and insufficiency (49%) at birth. Similarly, a multicenter study in China conducted by Yang et al [19] reported that vitamin D deficiency was seen most commonly in neonates. These two studies pointed to maternal vitamin D deficiency as the cause of vitamin D deficiency in infants.…”

Section: Discussionmentioning

confidence: 88%

“…Many studies also showed this relationship, as in the present study (Table 5). [9,13,16,[18][19][20] In contrast, some studies found a lower frequency of vitamin D deficiency in adolescents. [8,21] A cohort study of neonates performed by Kanike et al [22] reported a high prevalence of vitamin D deficiency (31%) and insufficiency (49%) at birth.…”

Section: Discussionmentioning

confidence: 98%

“…[20,[27][28][29] Many studies reported that vitamin D levels were at the lowest in spring and winter. [16,19] Sunlight exposure is the main factor in vitamin D synthesis. High latitudes are associated with inadequate levels of vitamin D. However; vitamin D insufficiency is not explained only by season and latitude.…”

Section: Discussionmentioning

confidence: 99%

“…Naiboglu et al [12] 2019 103 0-14 y 23.9±13.7 49 -Ture et al [8] 2020 [34] 2014 1488 7-11 y 18.4 (6.7-33.1) 56.4 23.3 Moore et al [18] 2015 2492 6-18 y -26.8 46.7 Al-Sadat et al [27] 2016 1361 13-15 y -92.6 -Beer et al [21] [19] 2020 460537 0-18 y 28.9±12.0 22.6 -Chen et al [26] 2021…”

Section: Discussionmentioning

confidence: 99%

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Frequency of Vitamin D Deficiency in Children: A Single-Center Cross-Sectional Study in Istanbul

Varkal¹,

Özçetin²,

Kılıç³

2021

Journal of Contemporary Medicine

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Aim: Vitamin D deficiency is highly prevalent among children worldwide. This study aims to assess the frequency of vitamin D deficiency in children and how it varies according to gender, age, and season in Istanbul. Material and Method:The study included 3096 children aged 0-18 admitted to the pediatric outpatient clinic in Istanbul. The serum 25 hydroxyvitamin D concentration was analyzed by the High-Performance Liquid Chromatography method using HPLC systems analyzers, and the results were categorized into four groups: deficiency (<20 ng/mL), insufficiency (20-30 ng/mL), sufficiency (30-100 ng/mL), and toxicity (>100 ng/mL). Descriptive methods, Chi-square, Independent Samples T-Test, ANOVA, and correlation test were used in the statistical analysis of the data.Results: Of children, 52% were girls and 48% boys. The mean serum 25 hydroxyvitamin D concentration was 21.8±15.8 ng/mL, and the frequency of vitamin D deficiency was 53.1%. There was a different distribution of vitamin D status between age groups. Vitamin D deficiency was more common in older children. The frequency of vitamin D deficiency was significantly higher in girls than boys (57.6% versus 48.3%). The mean serum 25 hydroxyvitamin D concentration was significantly lower in winter and spring. A moderate negative correlation was found between age and serum 25 hydroxyvitamin D concentration (correlation coefficient:-0.36). Conclusion:This study showed that female sex, older children, and the winter/spring seasons were significantly associated with a higher frequency of vitamin D deficiency and a lower mean serum 25 hydroxyvitamin D concentration.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Frequency of Vitamin D Deficiency in Children: A Single-Center Cross-Sectional Study in Istanbul

Varkal¹,

Özçetin²,

Kılıç³

2021

Journal of Contemporary Medicine

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“…Studies have shown that vitamin D de ciency is still widespread around the world [7,8]. But most of the studies focused on adults, children, pregnant or lactating women [9,[18][19][20]. The study about the vitamin D status in college students was very limited.…”

Section: Discussionmentioning

confidence: 99%

Diet, Physical Activity, and UV Protection Comprehensively Influenced Vitamin D Status: A Cross-Section Study of Chinese College Students

Luo

Zhang

et al. 2021

Preprint

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Background: Vitamin D deficiency is a major public health problem in China while there are seldom reports about vitamin D nutrition status in Chinese college students. The purpose of this study is to explore the vitamin D status of the college freshmen who came from different provinces of China and to comprehensive analyze the effects of diet, physical activity, and UV protection on serum vitamin D levels. Methods: Totally 1,667 freshmen who came from 26 provinces, autonomous districts or municipalities, were recruited into this study. An online questionnaire was used to collect the information including demographic status, diet habit, physical activity, and UV protection of the participants. Serum 25(OH)D3 concentrations were measured using a liquid chromatograph mass spectrometer. Multivariate linear regression analyses were used to explore the comprehensive influence of diet, physical activity, and UV protection on serum 25(OH)D3 levels. Results: The average age of the subjects was18.55±0.90 years, with 23.0% male and 77.0% female. The mean serum 25(OH)D3 was 18.06±6.34ng/mL and the proportion of vitamin D deficiency and insufficiency was 67.5% and 27.8%, respectively. Multivariate linear regression indicated that milk and yogurt intake≥200mL/d, calcium or vitamin D supplements and average time of outdoor activity ≥60 min/day were positively linked to higher serum vitamin D while sweets intake ≥10g/d and higher UV protection index were negatively influenced serum vitamin D after adjusted for age, gender, students’ original residence, latitudes and longitude. Conclusions: Vitamin D deficiency is an important health problem in Chinese college students. Milk and yogurt intake and outdoor activity should be encouraged while sweets intake should be limited for preventing vitamin D deficiency. Public health policies should consider well-balanced guidelines on UV protection and vitamin D food fortification or supplementation.

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Vitamin D status among infants and children in Shanghai, China: A hospital‐based study

Wang

et al. 2023

Food Science & Nutrition

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The variation in vitamin D status is still unclear. We aim to describe the vitamin D status among healthy infants and children in Shanghai (31° N latitude), one of the largest cities in China. We conducted a hospital‐based, 2‐year retrospective observational study and recruited children for health examination at the Tongren Hospital affiliated with Shanghai Jiao Tong University School of Medicine from January 2019 to December 2020. Serum 25‐hydroxyvitamin D (25(OH)D) levels were measured using an enzyme‐linked immunosorbent assay. A total of 6164 children aged 0–11 years were included. Of these, 94.4% of the serum 25(OH)D measurements at first assessment were within the range of 12–50 ng/mL. The median 25(OH)D level was 31.3 (IQR 25.6, 38.1) ng/mL, the percentages of 25(OH)D < 20 ng/mL and 25(OH)D < 30 ng/mL were 10.0% and 43.8%, respectively. Low vitamin D status (deficiency and insufficiency) differed significantly by age group (infants, toddlers, preschoolers, and schoolers) and seasonality (all p < .001), but not by gender. For the sub‐group (n = 855) of children with repeated assessments, their low 25(OH)D levels increased significantly whether after about a 7‐month (n = 351) or 12‐month (n = 504) interval, and the increments of median 25(OH)D levels were 8.1 ng/mL and 2.1 ng/mL respectively (p < .001). This study documents the vitamin D status in Shanghai, showing that low vitamin D status is common in infants and children and suggesting that the assessment of 25(OH)D level is necessary for individuals who are at risk for deficiency or excess.

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Prevalence of vitamin D deficiency and insufficiency among 460,537 children in 825 hospitals from 18 provinces in mainland China

Cited by 20 publications

References 15 publications

Frequency of Vitamin D Deficiency in Children: A Single-Center Cross-Sectional Study in Istanbul

Frequency of Vitamin D Deficiency in Children: A Single-Center Cross-Sectional Study in Istanbul

Diet, Physical Activity, and UV Protection Comprehensively Influenced Vitamin D Status: A Cross-Section Study of Chinese College Students

Vitamin D status among infants and children in Shanghai, China: A hospital‐based study

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