Prevalence of Vitamin-D deficiency is related to severity of liver damage in Hepatitis-C patients

Falak, Sadia; Aftab, Lubna; Saeed, Muhammad Usman; Islam, Aftab

doi:10.12669/pjms.36.3.1490

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…Inverse relationship between severity of liver disease and vitamin D levels was reported as 55.2% of decompensated cirrhosis patients were Vitamin-D deficient compared to 13.6% in compensated cirrhosis by Falak etal (22) In this study we found that in patients with liver cirrhosis vitamin D has inverse relationship with Child Pugh class as deficiency is more common as the Child class progresses. Patients with Child A cirrhosis 6/10 (60%) had deficiency, with child B 66/82 (80.5%) while with Child C 72/78 (92.3%) had deficiency of Vitamin D3.…”

supporting

confidence: 50%

Frequency of Vitamin D deficiency in liver cirrhosis and its correlation with Child Pugh Score

Dilshad¹,

Rasool²,

Latif³

et al. 2021

PJMHS

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Objective: To determine the frequency of vitamin D deficiency in patients with liver cirrhosis and the relationship of vitamin D deficiency with Child Pugh Class in patients with cirrhosis. Materials and Methods: Vitamin D and calcium levels were checked in patients with cirrhosis of liver aged 18 to 80 years admitted in Gastroenterology department of Lahore General Hospital. Investigations were also done to calculate Child Pugh (CTP) score and Child Class was assigned on the basis of score. Quantitative variables were expressed in terms of mean and standard deviation. Frequency and percentage were used for qualitative measures. The p-value was calculated by the contingency coefficient to find a relationship of vitamin D levels to CTP scores of liver cirrhosis. Data was analyzed using SPSS 24 Study Duration: The study was carried out from December 2019 to October 2020 Results: A total of 170 patients with mean age of 43.82 ± 9.72 (19-61) years were evaluated of which 144 (84.7%) were males, 26 (15.3%) were females. Vitamin D3 deficiency was found in 144/170 (84.7%) patients while insufficiency was found in 14/170(8.2 %). It was more common in male patients (86.1%) compared to female patients (76.9%). Mean vitamin D3 levels was 14.4 ± 9.4 ng/ ml. Patients with Child A cirrhosis 6/10 (60%) had deficiency, with child B 66/82 (80.5%) while with Child C 72/78 (92.3%) had deficiency of Vitamin D3. Conclusion: Vitamin D deficiency is common in patients with cirrhosis and level has decreased stepwise with higher Child Pugh Class. Keywords: Cirrhosis, Vitamin D, Child Pugh score

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supporting

confidence: 50%

Frequency of Vitamin D deficiency in liver cirrhosis and its correlation with Child Pugh Score

Dilshad¹,

Rasool²,

Latif³

et al. 2021

PJMHS

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“…Another study has also shown significantly low vitamin D levels in hepatitis C virus patients as compared to healthy subjects (Gao et al, 2016). Furthermore, this study showed the prevalence of 54.8% of vitamin D deficiency (referring to serum 25(OH)D concentrations < 20 ng/ml), which is slightly lower compared to the global prevalence of vitamin D deficiency among chronic liver disease populations ranging from 64 to 92% (Zhao et al, 2016, Falak et al, 2020.…”

Section: Discussionmentioning

confidence: 64%

A Cross-Sectional Study of Vitamin-D and Calcium Levels in Patients Living With Viral Hepatic Infections in Benin City, Nigeria

Bessong,

Adejumo,

Idiaghe

et al. 2023

OJBR

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The occurrence of vitamin D (25-(OH)D) insufficiency and hypocalcemia is associated with instances of chronic liver diseases. This investigation aimed to ascertain the prevalence of hypocalcemia and 25-(OH)D deficiency in people afflicted with viral liver infections and evaluate their serum calcium and 25-(OH)D concentrations to their respective characteristics. Forty-two individuals, with ages ranging from 20 to 70 years participated in the study. Within the sample population, a total of 29 individuals were diagnosed with hepatitis virus. The remaining thirteen participants consisted of healthy controls who were residents of Benin City. Blood samples were collected from the participants, followed by centrifugation to separate the serum. The resulting serum was then stored at a temperature of -20 degrees Celsius. The amounts of calcium and vitamin D were quantified using Calcium AMP/CPC tests and vitamin-D ELISA kits, respectively. The findings of the study indicated that 54.8% of the participants exhibited a deficiency in vitamin D, while 11.9% of the participants displayed hypocalcemia. A significant (p <0.001) decrease in calcium and 25-(OH)D levels was also observed among patients diagnosed with hepatitis A, B, and C compared to the control group. People who took 25-(OH)D supplements, had significantly higher calcium levels (p < 0.001) than people who did not take supplements. Based on our research, it seems likely that giving 25-(OH)D supplements to people with viral liver infections could help them get better in future programs aimed at treating vitamin D deficiency and low calcium levels.

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“…5 In a separate study conducted by Falak et al, it was observed that a significant proportion of patients, specifically 76.5%, exhibited a shortage in vitamin D levels. 8 The elevated prevalence of vitamin D deficiency seen in these studies could potentially be attributed to a higher proportion of female participants in comparison to male patients. The general population and those with chronic liver disease both demonstrate a notable correlation between gender and the occurrence of vitamin D insufficiency.…”

Section: Discussionmentioning

confidence: 83%

“…However, other research has failed to discover any significant variation in vitamin D levels between cirrhotic and noncirrhotic patients, or between different Child-Pugh groups. 8 Vitamin D insufficiency in alcoholics and those with cholestatic liver disease has received much of the attention. So, we set out to see how common vitamin D insufficiency is and how it relates to the degree of liver dysfunction among people who have chronic liver disease of diverse etiologies.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Impact of Vitamin D Deficiency Among Individuals Diagnosed with Chronic Liver Disease

Ullah,

Shaukat,

Abdullah

et al. 2023

PJMHS

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Introduction: Chronic liver disease is characterized by multi-nutrient deficiency. The propensity for individuals to have vitamin D insufficiency is greater in comparison to other essential minerals. Fibrosis results in a decline in the liver's ability to perform synthetic functions ultimately leading to lack of vitamin D due to poor activation caused by drop in proteins binding the vitamin. The situation is exacerbated by the decrease in productivity and the presence of nutritional deficiencies. Materials and Methods: The present descriptive research was carried out in the Department of Medicine at DHQ Teaching Hospital Haripur spanning from 1st January 2022 to 31st December 2022. The study population consisted of individuals between the ages of 40 and 70 years who were diagnosed with chronic liver disease. The concentration of vitamin D was assessed in blood samples obtained from patients at the hospital laboratory. The established threshold for identifying vitamin D insufficiency is a blood vitamin D level below 30 nmol/L. Data analysis was performed using statistical software SPSS version 24. Results: The age of the patients ranged from 40 to 70 years. The mean age of the patients was 53.40 years with standard deviation 12.194. Age wise distribution revealed 60.1% patients (n = 89) in the age group 40-55 years and 39.9% participants (n = 59) had age 56-70 years. The number of male participants were 94 (63.5%). Vitamin deficiency was observed in 64.9% patients (n = 96). The association of vitamin D deficiency with disease duration, child class and gender were statistically significant (p < 0.05). Conclusion: The potential association between vitamin D insufficiency and the extent of liver function impairment, degree of fibrosis, and susceptibility to infection consequences suggests that it may serve as a valuable prognostic indicator and diagnostic tool. Additional research is required to thoroughly assess and substantiate the significance of vitamin D in the context of liver cirrhosis. This necessitates the undertaking of extensive prospective cohort studies and randomized trials. Keywords: Vitamin D deficiency, Chronic Liver Disease (CLD)

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Prevalence of Vitamin-D deficiency is related to severity of liver damage in Hepatitis-C patients

Cited by 7 publications

References 22 publications

Frequency of Vitamin D deficiency in liver cirrhosis and its correlation with Child Pugh Score

Frequency of Vitamin D deficiency in liver cirrhosis and its correlation with Child Pugh Score

A Cross-Sectional Study of Vitamin-D and Calcium Levels in Patients Living With Viral Hepatic Infections in Benin City, Nigeria

Prevalence and Impact of Vitamin D Deficiency Among Individuals Diagnosed with Chronic Liver Disease

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