Prevalence of viral infections in Norwegian cats with and without feline lower urinary tract disease

Lund, Heidi Sjetne; Rimstad, Espen; Eggertsdóttir, Anna V

doi:10.1177/1098612x12459644

Cited by 13 publications

(15 citation statements)

References 26 publications

(62 reference statements)

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“…In addition, a correlation between lower urinary tract disease (LUTD) and infection of FmoPV has been reported recently [5]. LUTD including urethral obstruction (UO) and interstitial cystitic (IC) is also an important and common disease in domestic cats [10,11,[15][16][17][28][29][30]. Feline calicivirus, feline herpesvirus type II and feline foamy virus have been detected in some cats with LUTD [21,[28][29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological and pathological study of feline morbillivirus infection in domestic cats in Japan

et al. 2016

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BackgroundFeline morbillivirus (FmoPV) is a novel paramyxovirus found to infect domestic cats. FmoPV has been isolated in several countries in Asia and Europe and is considered to have genetic diversity. Also, it is suspected to be associated with feline renal diseases including tubulointerstitial nephritis (TIN), which affects domestic cats with a high incidence rate.ResultsTo clarify the state of FmoPV infection among domestic cats in Japan, an epidemiological survey was conducted. Twenty-one out of 100 cats were found to have serum antibodies (Ab) against FmoPV-N protein by indirect immunofluorescence assay (IF) using FmoPV-N protein-expressing HeLa cells. Twenty-two of the cats were positive for FmoPV RNA in the urine and/or renal tissues. In total, 29 cats were positive for Ab and/or viral RNA. These FmoPV-infected cats were classified into three different phases of infection: RNA+/Ab + (14 cats), RNA+/Ab- (8 cats) and RNA-/Ab + (7 cats). In immunohistochemistry (IHC), 19 out of 29 cats were positive for FmoPV-N protein in kidney tissues; however, the FmoPV-N protein was located in the inflammatory lesions with severe grade in only four out of the 19 cats. Since 15 out of 29 infected cats were positive for viral RNA and Ab, approximately half of the infected cats were persistently infected with FmoPV.ConclusionsA statistically significant difference was observed between infection of FmoPV and the presence of inflammatory changes in renal lesions, indicating a relationship between FmoPV infection and feline renal diseases. However, we could not obtain histopathological evidence of a relationship between FmoPV infection and TIN.

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Section: Discussionmentioning

confidence: 99%

Epidemiological and pathological study of feline morbillivirus infection in domestic cats in Japan

et al. 2016

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“…[13][14][15][16] DNA preparation DNA was isolated from 200 µl well-mixed non-sedimented urine using the QIAamp DNA mini kit (Qiagen) following the manufacturer's instructions, with the exception of the amount of elution buffer used in the final steps. A reduced volume of 50 µl elution buffer was used in order to increase the final DNA concentration in the eluate.…”

Section: Methodsmentioning

confidence: 99%

Absence of bacterial DNA in culture-negative urine from cats with and without lower urinary tract disease

Lund

Skogtun

Sørum

et al. 2014

Journal of Feline Medicine and Surgery

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A diagnosis of bacterial cystitis commonly relies on a positive microbiological culture demonstrating the presence of a significant number of colony-forming units/ml urine, as urine within the upper urinary tract, bladder and proximal urethra generally is considered sterile. Recent studies from human and veterinary medicine indicate the presence of non-culturable bacteria in culture-negative urine samples. The aim of the present study was to determine the occurrence of bacterial DNA in culture-negative urine samples from cats with signs of feline lower urinary tract disease (FLUTD) and healthy control cats by 16S ribosomal DNA PCR and subsequent sequencing. The study sample included 38 culture-negative urine samples from cats with FLUTD and 43 culture-negative samples from control cats. Eight culture-positive urine samples from cats with FLUTD were included as external positive controls in addition to negative reaction controls. Of possible methodological limitations, degradation of DNA due to storage, the use of non-sedimented urine for DNA isolation and lack of internal positive reaction controls should be mentioned. The positive controls were recognised, but occurrence of bacterial DNA in culture-negative urine from cats with or without signs of lower urinary tract disease was not demonstrated. However, considering the possible methodological limitations, the presence of bacterial DNA in the urine of culture-negative FLUTD cats cannot be excluded based on the present results alone. Therefore, a prospective study reducing the possibility of degradation of DNA due to storage, in combination with modifications enhancing the chance of detecting even lower levels of bacterial DNA in culture-negative samples, seems warranted.

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“…in cats and dogs (25,179,240,425). Viruses have also been detected in feline urine, including Herpesvirus (259) and Calicivirus (222). This section will herein focus only on bacterial urinary tract infection as clinical infection with other pathogen types in Australia is very rare ( Table 1-…”

Section: Aetiology and Risk Factorsmentioning

confidence: 99%

“…Therefore, the prevalence of urolithiasis in cats is similar to dogs, at up to 0.5% (calculated by the author from the above percentages). Besides FIC, other less common causes of FLUTD include bacterial, fungal or parasitic infection, urethral plugs, uroliths, anatomic abnormalities, trauma, neurological disease and iatrogenic causes (259,316,460).…”

Section: Inflammatory Bladder Diseasesmentioning

confidence: 99%

“…The welfare of cats with FIC is severely compromised, with a mortality rate of 12.5% that increases to 26% in cats with obstructive FIC, primarily due to elective euthanasia following repeated obstructive or non-obstructive episodes (98,142). The prevalence of feline lower urinary tract signs in the general cat population is 2-4.6% (171,198,258,259), with around two thirds of these cases attributed to FIC (62,98,110,231,232), therefore one in every 200 cats faces possible euthanasia due to the current lack of knowledge regarding the pathogenesis of FIC.…”

Section: Clinical Signs and Epidemiologymentioning

confidence: 99%

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Pathological and clinicopathological features of canine and feline bladder disease

Jones¹

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Dogs and cats commonly present to veterinary hospitals with urinary bladder disease, but despite their clinical importance and comparative potential to human diseases, bladder diseases in Australian dogs and cats are under investigated. In veterinary pathology, insufficient levels of diagnostic agreement can occur, and this is influenced by sample quality as well as the pathologist's own experience, training, and cognitive biases. Logistic regression is a statistical technique which, when applied to veterinary histopathology, could improve pathologist agreement. Thus, there were two overarching goals of this thesis-to investigate the pathology and comparative potential of canine and feline urinary bladder disease in Australia, and to explore the utility of logistic regression modelling in improving inter-pathologist agreement. This project conducted a retrospective evaluation of pathology cases of canine and feline urinary bladder tissue from the veterinary pathology archives of the

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Prevalence of viral infections in Norwegian cats with and without feline lower urinary tract disease

Cited by 13 publications

References 26 publications

Epidemiological and pathological study of feline morbillivirus infection in domestic cats in Japan

Epidemiological and pathological study of feline morbillivirus infection in domestic cats in Japan

Absence of bacterial DNA in culture-negative urine from cats with and without lower urinary tract disease

Pathological and clinicopathological features of canine and feline bladder disease

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