Prevalence of Viral Hepatitis in Pregnant Women in the Republic of Sakha (Yakutia)

Sleptsovа, S.S.; Douglas, N.I.; Rad, Yana G; Burtseva, T.E.; Gogolev, N.M.; Makaeva, Diana A.

doi:10.21103/article7(3)_oa15

Cited by 4 publications

(7 citation statements)

References 5 publications

(5 reference statements)

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“…Республика Саха (Якутия) относится к регионам с высоким уровнем распространённости хронических вирусных гепатитов, в том числе увеличением случаев заболеваемости гепатитом С, наиболее интенсивным вовлечением в эпидемический процесс лиц молодого возраста [6]. Сложность изучения распространённости HCV-инфекции среди жителей Республики обусловлена как латентным и малосимптомным течением у большинства больных, так и недостаточным охватом скрининга среди населения, а также географическими, климатическими особенностями региона, увеличением миграционных потоков в промышленных районах Республики, в условиях которых возрастает необходимость в проведении мониторинга эпидемиологической обстановки по гепатиту С.…”

Section: Infectious Diseasesunclassified

“…На фоне неблагоприятной эпидемиологической ситуации, сложившейся по ВГС-инфекции в РС (Я), следует также отметить стабильно высокие показатели инцидентности первичным раком печени в этом регионе, которые, как было показано нашими предыдущими исследованиями [6], на протяжении многих лет в 4-5 раз превышают среднероссийские показатели (рис. Определение генетических особенностей вируса даёт возможность эффективно проводить расследование групповых случаев заболеваний, способствует установлению эпидемиологической связи случаев между собой и с источником инфекции, выявлению завозных случаев заболеваний, получения расширенной эпидемиологической характеристики территорий [5,7].…”

Section: результаты и их обсуждениеunclassified

“…Из анализа данных следует, что у лиц коренной национальности преобладает генотип HCV 1b и 2а (80 % и 58,3 % соответственно). При генотипе 3а преобладающую часть составили некоренные жители Республики (61,5 %) [6].…”

Section: результаты и их обсуждениеunclassified

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HCV Infection in the Republic of Sakha (Yakutia) and Its Role of Genotypes in Clinical Outcomes of the Disease

Semenova

Sleptsovа

Malov

et al. 2020

Acta biomedica scientifica

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Aim of the research. To study the epidemic manifestations of HCV infection in the Republic of Sakha (Yakutia) in order to develop recommendations for improving the effectiveness and quality of treatment and prevention measures. Materials and methods. The paper uses materials from the official statistics of the Territorial Department of Rospotrebnadzor of the Republic of Sakha (Yakutia) for 1994–2018, and data from the electronic register «Chronic viral hepatitis in the RS (Ya)» (2019). Molecular and biological studies of the genotype of the hepatitis C virus were performed jointly on the basis of the Federal state budgetary Institution «Central research Institute of epidemiology» of Rospotrebnadzor (2007–2011, n = 75). To assess the epidemiological situation, the rate of increase in morbidity is calculated on the basis of data equalized by the method of least squares. Statistical processing was performed using the SPSS 17 program. The critical significance level is assumed to be 0.05. Results. Thus, the study of long-term dynamics of the incidence of viral hepatitis shows that in the Republic of Sakha (Yakutia) a consistently high level of incidence of HCV with adverse trends in the development of the epidemic process remains. Analysis of the distribution of different variants of HCV genotypes allowed us to establish the prevalence of genotype 1b, which can determine the high frequency of cirrhosis and primary liver cancer. The current situation in the Republic regarding the incidence of viral hepatitis requires detailed monitoring, improvement of epidemiological surveillance and introduction of modern treatment methods. It is also necessary to improve the quality of health education among the population of the Republic.

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Section: Infectious Diseasesunclassified

Section: результаты и их обсуждениеunclassified

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HCV Infection in the Republic of Sakha (Yakutia) and Its Role of Genotypes in Clinical Outcomes of the Disease

Semenova

Sleptsovа

Malov

et al. 2020

Acta biomedica scientifica

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“…(7) The Republic of Sakha (Yakutia) (RS(Y)) is one of the regions of Russia that is unfavorable for the prevalence of viral hepatitis B, C and D, as well as their adverse outcomes-cirrhosis and primary liver cancer. (8) According to the electronic register "Chronic viral hepatitis in Yakutia," 14,791 people are registered and 4.3% of them have chronic triple infection with hepatitis B, C, and D viruses.…”

Section: Introductionmentioning

confidence: 99%

Chronic Triple Infection with Hepatitis B, C, and D Viruses in the Republic of Sakha (Yakutia)

Petrova¹,

Sleptsovа²,

Андреев³

et al. 2018

IJBM

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The purpose of this work was to study the features of the clinical course of mixed infections with hepatitis B+C+D viruses in the Republic of Sakha (Yakutia) (RS(Y)). Materials and Methods: The incidences of these infections were studied in the infectious disease department of the Yakutsk City Clinical Hospital. A total of 74 patients with chronic infection with hepatitis B, C, and D viruses were analyzed. The following markers of HBV (HBsAg, HBeAg, anti-HBcIgG, HBV DNA), HCV (anti-HCV) and HDV (anti-HDV, HDV RNA) were detected. Results: According to PCR (n=35), HCV-RNA was detected in 29(82.8%) patients. In 65.8% of cases, HCV-RNA replication was observed in the absence of HDV-DNA. Mono-replication of HBV (HBV-DNA+, HCV-RNA-) was detected in 17.1% patients, mono-replication of HCV (HBV-DNA-, HCV-RNA+) in 65.7% patients and mixed replication of viruses C, D and/or G (HBV-DNA-, HCV-RNA+, HDV-RNA+/HGV-RNA+) in 17.1% patients. The comparison of biochemical parameters of patients with chronic mixed hepatitis showed that more expressed changes are observed with the mixed replication than with the mono-replicative form of hepatitis.

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“…According to the population register "Chronic viral hepatitis in the RS(Y)," on January 1, 2016, the number of registered patients who were CHB and HBV carriers was 6,935 and 4,019, respectively, and the share of HBV infection in the overall structure of chronic hepatitis was 6.8%. [3] Patients with hematologic diseases are a group of individuals at high risk for HBV reactivation or development of acute HBV infection. This is primarily due to the development of secondary immunodeficiency on the background of the underlying disease, transfusion of the blood, and antitumor therapy.…”

Section: Introductionmentioning

confidence: 99%

Association of Chronic HBV Infection with Chronic Lymphoproliferative Disorders: A Review and Case Report

Sleptsovа¹,

Yadrichinskaya²,

Palchina³

et al. 2016

Int J Biomed

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This article presents a clinical report on the associated course of chronic hepatitis B virus (HBV) infection with Castleman's disease (CD). We noticed the reactivation of previously latent chronic hepatitis B (CHB) with high replicative activity of HBV DNA during the treatment of lymphoproliferative disease. This clinical case dictates the need for pre-emptive therapy of HBV infection with nucleoside analogues in patients who are receiving chemotherapy. (Int J Biomed. 2016;6(2):128-132.).

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Prevalence of Viral Hepatitis in Pregnant Women in the Republic of Sakha (Yakutia)

Abstract: The prevalence of viral hepatitis in pregnant women in the Republic of Sakha (Yakutia) (RS(Y)) for 2007-2016 is presented in this article.

Cited by 4 publications

References 5 publications

HCV Infection in the Republic of Sakha (Yakutia) and Its Role of Genotypes in Clinical Outcomes of the Disease

HCV Infection in the Republic of Sakha (Yakutia) and Its Role of Genotypes in Clinical Outcomes of the Disease

Chronic Triple Infection with Hepatitis B, C, and D Viruses in the Republic of Sakha (Yakutia)

Association of Chronic HBV Infection with Chronic Lymphoproliferative Disorders: A Review and Case Report

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