Prevalence of very mild and mild dementia in community-dwelling older Chinese people in Hong Kong

Lam, Linda Chiu Wa; Tam, Cindy W. C.; Lui, Victor W. C.; Chan, Wai-Chi; Chan, Sandra Sau Man; Wong, Sunny H.; Wong, Ada; Tham, May Ked; Ho, Kin Sang; Chan, Wai Man; Chiu, Helen Fung Kum

doi:10.1017/s1041610207006199

Cited by 111 publications

(104 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It should be noted that the low MMSE scores appeared to be on par with that reported for the community elderly persons with mild cognitive impairment and mild dementia in the local population with a generally low education level. 26 Among all clinical characteristics, higher proportion of ApoE ε4 allele was found in mVCI subjects, as epidemiological studies from various populations showed the prevalence of ApoE ε4 allele in ≈50% of patients with late-onset Alzheimer's pathology. [27][28][29] Mounting experiment evidence suggest that ApoE4 could accelerate Aβ accumulation by increasing aggregation and impairing clearance of Aβ.…”

Section: Discussionmentioning

confidence: 99%

Influence of Amyloid-β on Cognitive Decline After Stroke/Transient Ischemic Attack

Liu

Wong

et al. 2015

Stroke

View full text Add to dashboard Cite

C ognitive impairment in the context of stroke or transient ischemic attack (TIA) is a prototype of vascular cognitive impairment (VCI). Our recent in vivo study using carbon-11-labeled Pittsburgh compound B ( 11 C-PiB) positron emission tomography (PET) found that ≈30% of subjects with poststroke/TIA cognitive impairment harbored Alzheimer's pathology.1 Although some studies suggested that in patients with clinical Alzheimer's disease (AD), comorbid cerebrovascular disease was associated with a more rapid cognitive decline, 2,3 it is still unknown whether concurrent presence of Alzheimer's pathology is associated with a faster cognitive deterioration in patients with poststroke/TIA cognitive impairment.In this study, we compared the longitudinal cognitive changes between VCI patients with and without AD-like amyloid-beta (Aβ) deposition measured using 11 C-PiB PET. We hypothesized that over 3 years, PiB-positive VCI (mixed VCI [mVCI]) subjects would experience a more rapid and continuous course of cognitive deterioration, resulting in more severe cognitive impairment than those who were PiB-negative (pure VCI [pVCI]). Methods SubjectsSubjects of this study were participants of the ongoing Stroke Registry Investigating cognitive Decline (STRIDE) study. 1 In the Background and Purpose-We hypothesized that comorbid amyloid-beta (Aβ) deposition played a key role in long-term cognitive decline in subjects with stroke/transient ischemic attack. Methods-We recruited 72 subjects with cognitive impairment after stroke/transient ischemic attack to receive Carbon-11-labeled Pittsburgh compound B positron emission tomography. We excluded subjects with known clinical Alzheimer's disease. Those with and without Alzheimer's disease-like Aβ deposition were classified as mixed vascular cognitive impairment (mVCI, n=14) and pure VCI (pVCI, n=58), respectively. We performed Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment to evaluate global cognition and cognitive domains (memory, visuospatial function, language, attention, and executive function) at 3 to 6 months (baseline) and annually for 3 years after the index event. We compared cognitive changes between mVCI and pVCI using linear mixed models and analysis of covariance adjusted for age and education. Results-Over 3 years, there were significant differences between mVCI and pVCI on change of MMSE score over time (group×time interaction, P=0.007). We observed a significant decline on MMSE score (P=0.020) in the mVCI group but not in the pVCI group (P=0.208 6 were performed on subjects at 3 to 6 months (baseline) after the index event to index general cognition. Then subjects were further invited to return for annual follow-up. This study analyzed the data collected ≤3 years.This substudy included a sample of 72 subjects with cognitive impairment (CDR grade ≥0.5) from the STRIDE study. Clinical diagnoses were made by 2 neurologists specialized in dementia (V.C.T.M. and L.A.). Thirty-six subjects had CDR grade of ≥1 and met the criteria for dementia acco...

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of Amyloid-β on Cognitive Decline After Stroke/Transient Ischemic Attack

Liu

Wong

et al. 2015

Stroke

View full text Add to dashboard Cite

show abstract

“…As a result, the burden of chronic diseases, such as dementia, will rise dramatically in the coming decades. In fact, the current estimates of dementia prevalence (Table 1) may be too conservative in light of more aggressive efforts toward early diagnosis (Lam et al, 2008a). In terms of living arrangement, 60% of older people in 2011 were living with children, 24.8% with a spouse and no children, and 12.7% were living alone (Census and Statistics Department, n.d.).…”

Section: Demographic Situationmentioning

confidence: 99%

Hong Kong: Embracing a Fast Aging Society With Limited Welfare

Cheng

Lum

Lam³

et al. 2013

The Gerontologist

View full text Add to dashboard Cite

With a noninterventionist government and an ideology emphasizing family self-reliance, yet one of the oldest populations around the world, Hong Kong faces many unresolved policy issues in aging, including public financial support, long-term care, and the lack of health or mental health care policies for older people. Despite funding limitations, research is vibrant and population aging is drawing more researchers into the field. Following a review of some of the major research activities, we conclude with some observations on a few key issues for the field of gerontology to move forward with in Hong Kong.

show abstract

“…1 In Hong Kong, the prevalence of mild dementia has been reported to be 8.9% for adults aged 70 years or over, with 64.6% suffering from AD. 2 …”

Section: Introductionmentioning

confidence: 99%

Impact of 18FDG PET and 11C-PIB PET brain imaging on the diagnosis of Alzheimer’s disease and other dementias in a regional memory clinic in Hong Kong

Shea

et al. 2016

Hong Kong Med J

View full text Add to dashboard Cite

Prevalence of very mild and mild dementia in community-dwelling older Chinese people in Hong Kong

Abstract: A sizable proportion of community-living subjects suffered from milder forms of dementia. They represent a high risk for early intervention to reduce potential physical and psychiatric morbidity.

Cited by 111 publications

References 29 publications

Influence of Amyloid-β on Cognitive Decline After Stroke/Transient Ischemic Attack

Influence of Amyloid-β on Cognitive Decline After Stroke/Transient Ischemic Attack

Hong Kong: Embracing a Fast Aging Society With Limited Welfare

Impact of 18FDG PET and 11C-PIB PET brain imaging on the diagnosis of Alzheimer’s disease and other dementias in a regional memory clinic in Hong Kong

Contact Info

Product

Resources

About