Prevalence of venous thromboembolism in patients with acetabular or hip fractures and their association with hemoglobin concentration

Althuwaykh, Salem H; Alnasser, Abdulrhman; Khubrani, Abdullah; Alamari, Zeyad; Aljuhani, Wazzan S

doi:10.4103/jmsr.jmsr_86_19

Cited by 2 publications

(1 citation statement)

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“…[25]. In addition, the incidence of DVT in patients with acetabular fractures was significantly higher than that of patients with pelvic fractures According to Althuwaykh et al, the incidence in a series of 404 patients with acetabular fracture was 5%, while PE had 1.7% patients [26]. Despite the prophylaxis, the prevalence of post-traumatic and postoperative thromboembolism is approximately 11% [27].…”

Section: Primary Total Hip Replacement After Acetabular Fracturementioning

confidence: 99%

Fractures of the acetabulum - surgical treatment and complications

2020

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Acetabular fractures represent severe injuries that mostly occur in car accidents, or after falling from greater heights, most often in the working male population. Acetabular fractures are present in our clinical practice and require a good education and surgical training. Surgical experience is one of the prerequisites for achieving good treatment results, because these fractures are accompanied by numerous complications. In order to acquire knowledge and skills in this field of surgery, it is necessary to have a national center for education at one of the Medical Faculties in Serbia. All dislocated acetabular fractures (? 2mm), require early surgery, anatomical reduction and stable internal fixation of acetabular fracture. Acetabular fracture-dislocation requires urgent reduction of the dislocated femoral head. The anatomic reduction of the fracture is related to the time of definitive bone fixation of the fracture. After 14 days from the fracture, anatomic reduction is more difficult to achieve. In addition to these factors that positively affect the final results of treatment, there are negative factors as well, that result in poor outcomes. They are directly correlated to the initial trauma that occurs at the time of injury. Fracture comminution, large dislocation (> 20mm), injury of the femoral head, posterior dislocation of the hip, impaction, traumatic or iatrogenic sciatic nerve palsy, are factors that negatively affect the results and are responsible for complications, as opposed to positive factors.

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Section: Primary Total Hip Replacement After Acetabular Fracturementioning

confidence: 99%

Fractures of the acetabulum - surgical treatment and complications

2020

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Determination of rivaroxaban in rat plasma by ultra‐high‐performance liquid chromatography–Q‐Orbitrap high‐resolution mass spectrometry and its application to a pharmacokinetic study

Jiang

Yan

2022

Biomedical Chromatography

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Therapeutic drug monitoring is critical to decrease the incidence rate of bleeding and thrombosis for personalized treatment with rivaroxaban, especially for drug interaction treatment, patients with renal dysfunction, elderly patients, patients with cardiovascular problems, and so on. In addition, an accurate analytical method is necessary for therapeutic drug monitoring. This study developed a ultra-HPLC-tandem Orbitrap high-resolution MS (UHPLC-Q-Orbitrap HRMS) method to accurately identify and quantify rivaroxaban in rat plasma. The isotope internal standard method was applied for accurate quantification. Rivaroxaban-d 4 was selected as the isotope internal standard substance. The m/z 436.07263 ([M + H] + ) was selected as the precursor ion and m/z 144.95085 and m/z 231.11259 were selected as the main product ions for rivaroxaban. The lower limit of quantification of rivaroxaban in plasma was 0.01 mg/L. The intra-and inter-day precisions were ≤3.65% and ≤8.16%, while the recoveries ranged from 87.4% to 95.2%. This analysis method was simple, low cost, and easy to operate. The developed and validated method was subsequently applied to successfully investigate the pharmacokinetic parameters of rivaroxaban in rats after its oral administration. These results could be helpful to promote further research regarding the mechanisms of rivaroxaban and drug interaction, which can avoid false positives due to high-precision identification of the proposed method.

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Prevalence of venous thromboembolism in patients with acetabular or hip fractures and their association with hemoglobin concentration

Cited by 2 publications

References 1 publication

Fractures of the acetabulum - surgical treatment and complications

Fractures of the acetabulum - surgical treatment and complications

Determination of rivaroxaban in rat plasma by ultra‐high‐performance liquid chromatography–Q‐Orbitrap high‐resolution mass spectrometry and its application to a pharmacokinetic study

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