Prevalence of Urogenital Mycoplasmas and Ureaplasmas in Women After Kidney Transplantation

Ekiel, Alicja; Pietrzak, Bronisława; Kamiński, Paweł; Doleżych, Hanna; Jóźwiak, Jarosław; Martirosian, Gayane

doi:10.1097/tp.0b013e318199d19a

Cited by 20 publications

(12 citation statements)

References 25 publications

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“…One such population of immunocompromised individuals is solid organ transplant recipients. Ekiel et al found increased Ureaplasma and Mycoplasma urogenital colonization of kidney transplant and dialysis patients compared with age‐matched controls. They found a fourfold increase in U urealyticum colonization among transplanted and dialysis patients as well as a 50% increase in any Mycoplasmatale.…”

Section: Discussionmentioning

confidence: 96%

Ureaplasma urealyticum pyelonephritis presenting with progressive dysuria, renal failure, and neurologic symptoms in an immunocompromised patient

Schwartz

Elward

Storch

et al. 2018

Transplant Infectious Dis

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Ureaplasma urealyticum is a bacterial species correlated with urethritis in healthy individuals and invasive infections in immunocompromised patients. We describe a 20-year-old female with a history of remote heart transplant on everolimus, my cophenolate, and rituximab presenting with progressive urinary tract symptoms, renal failure, and neurologic symptoms. An extensive workup ultimately identified U urealyticum infection, and the patient successfully recovered after a course of azithromycin and doxycycline.

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Section: Discussionmentioning

confidence: 96%

Ureaplasma urealyticum pyelonephritis presenting with progressive dysuria, renal failure, and neurologic symptoms in an immunocompromised patient

Schwartz

Elward

Storch

et al. 2018

Transplant Infectious Dis

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“…Ekiel et al reported a higher frequency of urogenital colonization with U. urealyticum in young asymptomatic female kidney allograft recipients or dialysis patients (10%) as compared to matched healthy individuals (2.5%), whereas other Mycoplasma spp. with a less pathogenic potential are found equally often.…”

Section: Discussionmentioning

confidence: 99%

Ureaplasma and Mycoplasma in kidney allograft recipients—A case series and review of the literature

Gerber

Gaspert

Braghetti

et al. 2018

Transplant Infectious Dis

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Ureaplasma urealyticum and Mycoplasma hominis are common inhabitants of the human genital tract. Increasingly, serious and sometimes fatal infections in immunocompromised hosts have been reported, highlighting their pathogenic potential. We reviewed the clinical impact of positive Ureaplasma spp. and Mycoplasma spp. urine cultures in 10 renal allograft recipients who presented with sterile leukocyturia. Five recipients remained asymptomatic. Five patients were symptomatic with dysuria or pain at the graft site. Three patients developed biopsy-proven acute graft pyelonephritis with graft dysfunction. One of these patients additionally showed a renal abscess as demonstrated by magnetic resonance imaging (MRI). All were successfully treated. A literature search revealed a substantial number of case reports with severe and sometimes fatal Ureaplasma spp. or Mycoplasma spp. infections in immunocompromised patients. Colonization rate is high in renal transplant patients. A subset of patients is at risk for invasive disease.

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“…Although coinfections were common, multiple logistic regression revealed that only MG colonization was significantly associated with cervicitis [6]. Among nonpregnant women, MG also has been associated with salpingitis and in a study of Cefoxitin treatment of salpingitis, failure to eliminate symptoms was attributed to eradicate MG [7]. And in a study of Swedish women undergoing elective termination, postabortal salpingitis was associated with MG colonization in 2.8% of women, furnishing an odds ratio above 6-fold compared to noncolonized women [8].…”

Section: Mycoplasma Genitalium (Mg)mentioning

confidence: 99%

Mycoplasma,Ureaplasma, and Adverse Pregnancy Outcomes: A Fresh Look

Larsen

Hwang

2010

Infectious Diseases in Obstetrics and Gynecology

113

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Recent work on the Molicutes that associate with genital tract tissues focuses on four species that may be of interest in potential maternal, fetal, and neonatal infection and in contributing to adverse pregnancy outcomes. Mycoplasma hominis and Ureaplasma urealyticum have historically been the subject of attention, but Mycoplasma genitalis which causes male urethritis in addition to colonizing the female genital tract and the division of Ureaplasma into two species, urealyticum and parvum, has also added new taxonomic clarity. The role of these genital tract inhabitants in infection during pregnancy and their ability to invade and infect placental and fetal tissue is discussed. In particular, the role of some of these organisms in prematurity may be mechanistically related to their ability to induce inflammatory cytokines, thereby triggering pathways leading to preterm labor. A review of this intensifying exploration of the mycoplasmas in relation to pregnancy yields several questions which will be important to examine in future research.

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Prevalence of Urogenital Mycoplasmas and Ureaplasmas in Women After Kidney Transplantation

Abstract: Our observation showed the necessity of careful examination of possible atypical pathogens in diagnostic materials from hemodialyzed and kidney transplant patients.

Cited by 20 publications

References 25 publications

Ureaplasma urealyticum pyelonephritis presenting with progressive dysuria, renal failure, and neurologic symptoms in an immunocompromised patient

Ureaplasma urealyticum pyelonephritis presenting with progressive dysuria, renal failure, and neurologic symptoms in an immunocompromised patient

Ureaplasma and Mycoplasma in kidney allograft recipients—A case series and review of the literature

Mycoplasma,Ureaplasma, and Adverse Pregnancy Outcomes: A Fresh Look

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