Prevalence of Unilateral and Bilateral Deafness in Border Collies and Association with Phenotype

Platt, Simon; Freeman, Julia; Stefani, AIberta di; Wieczorek, Lara; Henley, William

doi:10.1111/j.1939-1676.2006.tb00751.x

Cited by 37 publications

(41 citation statements)

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“…Similarly, in a study in Border Collie puppies [11], the prevalence of CHSD was significantly higher in offspring from unilaterally deaf dams (10%) compared with those from normal hearing dams (2%). In contrast, there was no significant association between parental and offspring hearing status in Australian Cattle Dogs and Bull Terriers [1], although in that study, only a few subjects had parents of known hearing status [1].…”

Section: Discussionmentioning

confidence: 72%

“…The literature is divided as to the effects of sex on the prevalence of CHSD. In some studies, no association was observed between sex and CHSD in a variety of breeds [1,8,11]. This included a study in Australian Cattle Dogs that used both binary (ie deaf/not deaf) and ordinal (normal/unilateral/bilateral) outcome variables [1].…”

Section: Discussionmentioning

confidence: 99%

“…Relationships between CHSD and sex have not been observed in Australian Cattle Dogs, Australian Stumpy-tail Cattle Dogs, Border Collies, Bull Terriers, and in some studies in Dalmatians [1,7,8,11]. In contrast, in other studies in Dalmatians, females were more likely to have CHSD [14,15,17].…”

Section: Introductionmentioning

confidence: 93%

“…In a study of 2,597 Border Collies, prevalence of deafness was higher in dogs with merle coat pigmentation, excessive white on the head, or blue eyes [11]. However, this contrasts with findings from a later study, where the prevalence of CHSD was not increased in Border Collies with increased white head patches [12].…”

Section: Introductionmentioning

confidence: 98%

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Prevalence of congenital hereditary sensorineural deafness in Australian Cattle Dogs and associations with coat characteristics and sex

et al. 2012

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BackgroundCongenital hereditary sensorineural deafness (CHSD) occurs in many dog breeds, including Australian Cattle Dogs. In some breeds, CHSD is associated with a lack of cochlear melanocytes in the stria vascularis, certain coat characteristics, and potentially, abnormalities in neuroepithelial pigment production. This study investigates phenotypic markers for CHSD in 899 Australian Cattle Dogs.ResultsAuditory function was tested in 899 Australian Cattle Dogs in family groups using brainstem auditory evoked response testing. Coat colour and patterns, facial and body markings, gender and parental hearing status were recorded.Deafness prevalence among all 899 dogs was 10.8% with 7.5% unilaterally deaf, and 3.3% bilaterally deaf, and amongst pups from completely tested litters (n = 696) was 11.1%, with 7.5% unilaterally deaf, and 3.6% bilaterally deaf.Univariable and multivariable analyses revealed a negative association between deafness and bilateral facial masks (odds ratio 0.2; P ≤ 0.001). Using multivariable logistic animal modelling, the risk of deafness was lower in dogs with pigmented body spots (odds ratio 0.4; P = 0.050).No significant associations were found between deafness and coat colour.Within unilaterally deaf dogs with unilateral facial masks, no association was observed between the side of deafness and side of mask. The side of unilateral deafness was not significantly clustered amongst unilaterally deaf dogs from the same litter. Females were at increased risk of deafness (odds ratio from a logistic animal model 1.9; P = 0.034) after adjusting for any confounding by mask type and pigmented body spots.ConclusionsAustralian Cattle Dogs suffer from CHSD, and this disease is more common in dogs with mask-free faces, and in those without pigmented body patches. In unilaterally deaf dogs with unilateral masks, the lack of observed association between side of deafness and side of mask suggests that if CHSD is due to defects in molecular pigment pathways, the molecular control of embryonic melanoblast migration from ectoderm to skin differs from control of migration from ectoderm to cochlea. In Australian Cattle Dogs, CHSD may be more common in females.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 98%

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Prevalence of congenital hereditary sensorineural deafness in Australian Cattle Dogs and associations with coat characteristics and sex

et al. 2012

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“…Although useful, alternative data sources including referral practice data [51], [52], [53], pet insurance databases [27], official health schemes [54], [55], [56] and large scale questionnaire surveys [26], [57], [58], [59] are reported to suffer many limitations for the generation of prevalence values that can be generalised to the wider dog population. Analyses based on primary-care veterinary EPR data benefit from open-ended data collection allowing generation of stronger evidence from cohort compared with cross-sectional study designs [60], [61], [62].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Disorders Recorded in Dogs Attending Primary-Care Veterinary Practices in England

et al. 2014

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Purebred dog health is thought to be compromised by an increasing occurence of inherited diseases but inadequate prevalence data on common disorders have hampered efforts to prioritise health reforms. Analysis of primary veterinary practice clinical data has been proposed for reliable estimation of disorder prevalence in dogs. Electronic patient record (EPR) data were collected on 148,741 dogs attending 93 clinics across central and south-eastern England. Analysis in detail of a random sample of EPRs relating to 3,884 dogs from 89 clinics identified the most frequently recorded disorders as otitis externa (prevalence 10.2%, 95% CI: 9.1–11.3), periodontal disease (9.3%, 95% CI: 8.3–10.3) and anal sac impaction (7.1%, 95% CI: 6.1–8.1). Using syndromic classification, the most prevalent body location affected was the head-and-neck (32.8%, 95% CI: 30.7–34.9), the most prevalent organ system affected was the integument (36.3%, 95% CI: 33.9–38.6) and the most prevalent pathophysiologic process diagnosed was inflammation (32.1%, 95% CI: 29.8–34.3). Among the twenty most-frequently recorded disorders, purebred dogs had a significantly higher prevalence compared with crossbreds for three: otitis externa (P = 0.001), obesity (P = 0.006) and skin mass lesion (P = 0.033), and popular breeds differed significantly from each other in their prevalence for five: periodontal disease (P = 0.002), overgrown nails (P = 0.004), degenerative joint disease (P = 0.005), obesity (P = 0.001) and lipoma (P = 0.003). These results fill a crucial data gap in disorder prevalence information and assist with disorder prioritisation. The results suggest that, for maximal impact, breeding reforms should target commonly-diagnosed complex disorders that are amenable to genetic improvement and should place special focus on at-risk breeds. Future studies evaluating disorder severity and duration will augment the usefulness of the disorder prevalence information reported herein.

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2018

Breed Predispositions to Disease in Dogs and Cats

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Prevalence of Unilateral and Bilateral Deafness in Border Collies and Association with Phenotype

Abstract: Associations between CSD and pigmentation patterns linked to the merle gene were demonstrated for Border Collies. Evidence for an inherited component to CSD in Border Collies supports selective breeding from only tested and normal parents to reduce the prevalence of this disease.

Cited by 37 publications

References 20 publications

Prevalence of congenital hereditary sensorineural deafness in Australian Cattle Dogs and associations with coat characteristics and sex

Prevalence of congenital hereditary sensorineural deafness in Australian Cattle Dogs and associations with coat characteristics and sex

Prevalence of Disorders Recorded in Dogs Attending Primary-Care Veterinary Practices in England

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