Prevalence of undiagnosed diabetes mellitus in male erectile dysfunction

Krishnamurthy, Sairam; Kulinskaya, Elena; Boustead, G.; Hanbury, Damian; McNicholas, Tom

doi:10.1046/j.1464-410x.2001.02260.x

Cited by 74 publications

(54 citation statements)

References 15 publications

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“…Surprisingly, diabetes as a risk factor for ED has not been evaluated prospectively in a population, and the lag time between the onset of diabetes and the increased risk of ED is unknown. There is some evidence that ED commonly precedes the diagnosis of diabetes (32). Previous studies of the relationship between ED and diabetes or glycemia are retrospective or cross-sectional (4 -7).…”

Section: Smokingmentioning

confidence: 99%

Heart disease risk factors predict erectile dysfunction 25 years later

Fung

Bettencourt

Barrett‐Connor

2004

Journal of the American College of Cardiology

277

185

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Section: Smokingmentioning

confidence: 99%

Heart disease risk factors predict erectile dysfunction 25 years later

Fung

Bettencourt

Barrett‐Connor

2004

Journal of the American College of Cardiology

277

185

View full text Add to dashboard Cite

show abstract

“…Some have suggested that it may be a biomarker for occult diabetes, 4,5 CVD, [6][7][8][9] and lower urinary tract infections. [10][11][12] ED has been shown to have a profound effect on the quality of life of aging men.…”

mentioning

confidence: 99%

The validity of a single-question self-report of erectile dysfunction

et al. 2005

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OBJECTIVE:To determine how well a single question of self-reported erectile dysfunction compares to a gold standard clinical urologic examination. DESIGN AND SETTING:Clinical validation study nested within the Massachusetts Male Aging Study (MMAS), which is an observational cohort study of aging and health in a population-based random sample of men.MEASUREMENT: During an in-person interview, men were asked to respond to a single-question self-report of erectile dysfunction. A subsample of MMAS participants was then subjected to a clinical urologic examination to obtain a clinical diagnosis of erectile dysfunction. PARTICIPANTS:One hundred thirty-nine men 55 to 85 years of age from the MMAS. RESULTS:Complete data were available from 137 men. Erectile dysfunction (ED) measured by self-report and independent urologic examination were strongly correlated (Spearman r =.80). Receiver operating curve analysis showed that the self-reported ED item accurately predicts the clinician-diagnosed ED (area under the curve [AUC] =0.888). Stratum-specific likelihood ratios (95% confidence intervals) for selfreports predicting the gold standard were: no ED =0.11 (0.06 to 0.22), minimal ED =1.48 (0.67 to 3.26), moderate ED =8.57 (1.21 to 60.65), and complete ED =12.69 (1.81 to 88.79). These data indicate that men diagnosed with ED by urologic examination can be distinguished from men not diagnosed with ED by urologic examination if the respondent self-reported no, moderate, or complete ED. CONCLUSION:Our single-question self-report accurately identifies men with clinically diagnosed ED, and may be useful as a referral screening tool in both research studies and general practice settings. (Table 1). We have previously shown that self-administration of this single question correlates well with the IIEF and the BMSFI, and that the proportion with missing data for the single question (9%) was similar to that for the BMSFI (8%) and lower than that for the IIEF (18% METHODSThe MMAS is an observational cohort study of health and aging in a population-based random sample of men. The design has been well-described elsewhere. 3,22,23 As part of the in-person interview, respondents were queried about erectile function with a single question. Table 1 presents the ED single question as it was presented to respondents in the MMAS. The substudy was described to all participants at the conclusion of the in-person interview, and each was offered the opportunity to participate. They were told that participation was strictly voluntary and independent of their participation in

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“…Sairam et al [15], for example, found that patients with type 2 diabetes had associated ED in 35-75% of cases.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Risk Assessment Using High-Sensitivity C-Reactive Protein in Patients with Erectile Dysfunction

et al. 2013

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Background: Erectile dysfunction (ED) is associated with cardiovascular events. High-sensitivity C-reactive protein (hsCRP) is a cardiovascular risk marker. The aim of this study is to determine whether hsCRP is useful in evaluating ED. Methods: In 121 patients with ED, age, ED type and severity, time since onset of ED, weight, height, BMI, body fat percentage, waist and hip circumference, hsCRP and hormone profile were studied. Patients were classified as low or moderate-high cardiovascular risk based on hsCRP levels. A descriptive and univariate study was performed. A logistic regression was used to establish factors associated with low versus moderate-high cardiovascular risk and hsCRP. Results: Most patients had moderate-severe ED (70%). 74% had a moderate-high cardiovascular risk based on hsCRP levels, and 33.9 and 34.7% had hypogonadism according to total (TT) and free testosterone. In the univariate analysis, a relationship between hsCRP and TT and physical examination variables was observed (p < 0.05). In the multivariate analysis, TT was found to be a predictor (OR: 0.676; 95% CI: 0.491-0.029). Higher cardiovascular risk was found in the hypogonadic group (OR: 5.51; 95% CI: 1.185-25.662) and waist- to-hip ratio (p = 0.008; OR: 1.361; 95% CI: 1.075-1.612). Conclusions: A majority of patients with ED have high cardiovascular risk based on hsCRP levels and there is an association with hypogonadism and obesity.

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Prevalence of undiagnosed diabetes mellitus in male erectile dysfunction

Cited by 74 publications

References 15 publications

Heart disease risk factors predict erectile dysfunction 25 years later

Heart disease risk factors predict erectile dysfunction 25 years later

The validity of a single-question self-report of erectile dysfunction

Cardiovascular Risk Assessment Using High-Sensitivity C-Reactive Protein in Patients with Erectile Dysfunction

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