Prevalence of ultrasonographic gastrointestinal wall changes in dogs with acute pancreatitis: A retrospective study (2012‐2020)

Hardwick, Joshua J.; Reeve, Elizabeth J; Hezzell, Melanie J; Reeve, Jenny

doi:10.1111/jvim.16414

Cited by 4 publications

(4 citation statements)

References 35 publications

(74 reference statements)

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“…10,19 Farklı hastalıklarda (akut pankreatitis, hipoadrenokortisizm, parvoviral enteritis ve yangısal bağırsak hastalığı), bağırsak duvar değişimlerinin ultrasonografiyle incelendiği araştırmalar olduğu hâlde daha önce renal hasarı bulunan köpeklerde ultrasonografi ile bağırsak duvar kalınlıkları ve anormalliğinin belirlendiği herhangi bir araştırmayla karşılaşılmamıştır. [21][22][23][24]…”

Section: Discussionunclassified

Intestinal Ultrasonography in Dogs with Acute Renal Injury: Prospective Assessment of the Renal-Intestinal Axis: A Randomized Clinical Study

GÖKÇAY,

ERDOĞAN,

ERDOĞAN

et al. 2024

Turkiye Klinikleri J Vet Sci

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Bu çalışma ile akut renal hasarı (ARH) bulunan köpeklerde, renal ve intestinal ilişkinin ultrasonografik olarak belirlenmesi ve ultrasonografik intestinal verilerin, ARH'ın erken belirteci olup olmayacağının ortaya konulması amaçlanmıştır. Gereç ve Yöntemler: Doğal yolla oluşan, ARH tanısı konulan ve herhangi bir şikâyeti bulunmayan sağlıklı olmak üzere her iki cinsiyetten ve farklı yaşlardaki (yaş aralığı 1-13) toplamda 64 köpek çalışmaya dâhil edilmiştir. Birinci grubu (n=24) sağlıklı köpekler, ikinci grubu (n=33) subklinik ARH'lı ve üçüncü grubu (n=7) tübüler zararla ilişkili ARH bulunan köpekler oluşturulmuştur. Bulgular: Subklinik ARH ile tübüler zararla ilişkili ARH kreatinin düzeyleri ve tüpüler zararla ilişkili ARH bulunan hastalarla, sağlıklı grup arasında anlamlı (p<0,001) bir farklılık tespit edilmiştir. Tübüler zararla ilişkili ARH bulunan hastalarda; kolon 3,3±0,1 mm, duodenum 5,1±0,4 mm, jejunum 4,4±0,3 mm olarak bulunurken, subklinik ARH grubuna dâhil edilen hastalarda; duvar kalınlıkları kolon 3,8±0,2 mm, duodenum 5,5±0,2 mm, jejunum 4,6±10,8 mm olarak tespit edilmiştir. Renal intestinal ilişki değerlendirildiğinde, yanlızca subklinik ARH'li köpeklerdeki intestinal değişimler sağlıklılara kıyasla anlamlı olarak kolon (p<0,001), duodenum (p<0,01) ve jejunum (p<0,05) bulunmuştur. Sonuç: ARH mevcut olan köpeklerde intestinal duvar kalınlıklarında artış görülmüştür. Elde edilen bu sonuçlar köpeklerde, böbrek-bağırsak iletişimini destekler niteliktedir. Anah tarKe li me ler: Akut renal hasar; disbiyozis; köpek; ultrasonografi ABS TRACT Objective: This study aims to elucidate the ultrasonographic interactions between the renal and intestinal domains in dogs afflicted with acute renal injury (ARI) and to ascertain the potential of ultrasonographic intestinal data as early indicators of ARI. Material and Methods: A cohort of 64 dogs, naturally diagnosed with ARI, encompassing both sexes and spanning diverse ages (1 to 13 years) was enrolled in the study. The first group (n=24) consisted of healthy dogs, the second group (n=33) comprised subjects with subclinical ARI, and the third group (n=7) consisted of individuals with ARI featuring tubular damage. Results: A significant difference (p<0.001) was observed in creatinine levels between subclinical ARI and ARI associated with tubular damage, as well as between patients with tubular damage-associated ARI and the healthy control group. In patients with ARI linked to tubular damage, the colon exhibited a wall thickness of 3.3±0.1 mm, the duodenum 5.1±0.4 mm, and the jejunum 4.4±0.3 mm, whereas those with subclinical ARI had a colon wall thickness of 3.8±0.2 mm, duodenum 5.5±0.2 mm, and jejunum 4.6±10.8 mm. Evaluation of the renalintestinal relationship revealed significant intestinal changes in dogs with only subclinical ARI compared to healthy dogs, particularly in the colon (p<0.001), duodenum (p<0.01), and jejunum (p<0.05) Conclusion: Dogs manifesting ARI demonstrated discernible augmentations in intestinal wall thickness. These findings lend support to th...

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Section: Discussionunclassified

Intestinal Ultrasonography in Dogs with Acute Renal Injury: Prospective Assessment of the Renal-Intestinal Axis: A Randomized Clinical Study

GÖKÇAY,

ERDOĞAN,

ERDOĞAN

et al. 2024

Turkiye Klinikleri J Vet Sci

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“…The UPASS is an indicator of the number of sonographic abnormalities of the pancreas. The presence or absence of gastrointestinal (GI) wall abnormalities were also recorded at each visit 21,22 …”

Section: Methodsmentioning

confidence: 99%

“…The presence or absence of gastrointestinal (GI) wall abnormalities were also recorded at each visit. 21 , 22 …”

Section: Methodsmentioning

confidence: 99%

Serial monitoring of pancreatic lipase immunoreactivity, C‐reactive protein, abdominal ultrasonography, and clinical severity in dogs with suspected pancreatitis

Mitchell,

Wang,

Lawver

et al. 2024

Veterinary Internal Medicne

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BackgroundDiagnosis of pancreatitis is based on clinical signs, pancreatic lipase immunoreactivity (cPLI), and abdominal ultrasonography (AUS). Diagnostic discrepancies exist between test results which might be related to differences in the timeline for resolution of these abnormalities after pancreatic injury.Hypothesis/ObjectivesTo evaluate disease severity, ultrasonographic findings, and serum biomarkers of pancreatitis in dogs over a period of 28‐days.AnimalsSixteen client‐owned dogs with a clinical suspicion for acute pancreatitis based on history/physical examination, an abnormal SNAP cPLI, and ultrasonographic evidence of pancreatitis.MethodsProspective observational study. Clinical severity (modified clinical activity index [MCAI]), cPLI, C‐reactive protein (CRP), and AUS were evaluated at days 0, 2, 7, and 28. Owner assessed overall health (OH) was noted. Dogs were stratified into baseline cPLI ≥400 μg/L vs <400 μg/L groups for reporting.ResultsThe median CRP, MCAI, and OH were 111.9 mg/L, 10, and 4/10 respectively in the cPLI ≥400 μg/L group. The median CRP, MCAI, and OH were 58.0 mg/L, 6, and 6/10 respectively in the cPLI <400 μg/L group. None of these variables were significantly different between groups. Most dogs (4/5) in the cPLI <400 μg/L group had a history of suspected pancreatitis (ie, suspect acute on chronic disease). cPLI and MCAI rapidly decreased in dogs with a baseline cPLI ≥400 μg/L, whereas sonographic evidence of pancreatitis persisted for a longer time period.Conclusions and Clinical ImportanceUltrasonographic evidence of pancreatitis in the absence of overt clinical or biochemical abnormalities might represent a resolving injury rather than active disease.

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“…AP is characterized by edema, necrosis, and neutrophilic infiltrates histologically ( Hardwick et al, 2022 ). The neutrophils are the prominent actors in the acute inflammation of AP, playing critical components of SAP and releasing cytokines that activate the inflammatory responses of several other immune cells ( Murthy et al, 2019 ; Andersson et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Identification and analysis of chemokine-related and NETosis-related genes in acute pancreatitis to develop a predictive model

Mo,

Wu,

Luo

et al. 2024

Front. Genet.

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Background: Chemokines and NETosis are significant contributors to the inflammatory response, yet there still needs to be a more comprehensive understanding regarding the specific molecular characteristics and interactions of NETosis and chemokines in the context of acute pancreatitis (AP) and severe AP (SAP).Methods: To address this gap, the mRNA expression profile dataset GSE194331 was utilized for analysis, comprising 87 AP samples (77 non-SAP and 10 SAP) and 32 healthy control samples. Enrichment analyses were conducted for differentially expressed chemokine-related genes (DECRGs) and NETosis-related genes (DENRGs). Three machine-learning algorithms were used for the identification of signature genes, which were subsequently utilized in the development and validation of nomogram diagnostic models for the prediction of AP and SAP. Furthermore, single-gene Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) were performed. Lastly, an interaction network for the identified signature genes was constructed.Results: We identified 12 DECRGs and 7 DENRGs, and enrichment analyses indicated they were primarily enriched in cytokine-cytokine receptor interaction, chemokine signaling pathway, TNF signaling pathway, and T cell receptor signaling pathway. Moreover, these machine learning algorithms finally recognized three signature genes (S100A8, AIF1, and IL18). Utilizing the identified signature genes, we developed nomogram models with high predictive accuracy for AP and differentiation of SAP from non-SAP, as demonstrated by area under the curve (AUC) values of 0.968 (95% CI 0.937–0.990) and 0.862 (95% CI 0.742–0.955), respectively, in receiver operating characteristic (ROC) curve analysis. Subsequent single-gene GESA and GSVA indicated a significant positive correlation between these signature genes and the proteasome complex. At the same time, a negative association was observed with the Th1 and Th2 cell differentiation signaling pathways.Conclusion: We have identified three genes (S100A8, AIF1, and IL18) related to chemokines and NETosis, and have developed accurate diagnostic models that might provide a novel method for diagnosing AP and differentiating between severe and non-severe cases.

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Prevalence of ultrasonographic gastrointestinal wall changes in dogs with acute pancreatitis: A retrospective study (2012‐2020)

Cited by 4 publications

References 35 publications

Intestinal Ultrasonography in Dogs with Acute Renal Injury: Prospective Assessment of the Renal-Intestinal Axis: A Randomized Clinical Study

Intestinal Ultrasonography in Dogs with Acute Renal Injury: Prospective Assessment of the Renal-Intestinal Axis: A Randomized Clinical Study

Serial monitoring of pancreatic lipase immunoreactivity, C‐reactive protein, abdominal ultrasonography, and clinical severity in dogs with suspected pancreatitis

Identification and analysis of chemokine-related and NETosis-related genes in acute pancreatitis to develop a predictive model

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