Prevalence of type 2 diabetes mellitus in a sample of the adult population of Alexandria, Egypt

Khalil, Samir Helmy Assaad; Megallaa, Magdy Helmy; Rohoma, Kamel Hemida; Ismael, Hanaa; Abou-Seif, M.; Kharboush, Ibrahim; Elkaffash, Dalal; Hassanein, Mohamed; Wahab, Moataza M. Abdel; Malaty, Amin; Sallam, Hassan

doi:10.1016/j.diabres.2018.07.025

Cited by 30 publications

(21 citation statements)

References 24 publications

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“…In this finding 248 (59%) were knowledgeable and 174 (41%) were poorly knowledgeable towards lifestyle modification. This result was higher than the studies conducted in South Africa 30 which was 7.8%, and 9.9% in Egypt, 31 (20.37%) in another study in South Africa. 32 But the result was lower than the study conducted in Adama 21 , which was found to be 77.59%.…”

Section: Discussioncontrasting

confidence: 64%

“…It was found to be lower than the studies conducted in Adama 81.89%, Botswana 89.4%, Egypt 89.3 %, and South Africa 84.3%, respectively. 21,30,31,33 The possible explanations for the variations in the attitude score about diabetes lifestyle modification might be due to the fact that health service, sociodemographic, and the scoring system variation. The cross-tabulation showed that the majority of participants in the age group of ≥30 years had a good attitude (50%) compared to <30 years of age (2.8%).…”

Section: Discussionmentioning

confidence: 99%

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<p>Knowledge, Attitude, and Practice Toward Lifestyle Modification Among Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital Northwest, Ethiopia</p>

Mekonnen

Abate

Tegegne

2020

DMSO

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Background: Diabetes, which is a non-communicable metabolic disease, imposes several complications and death worldwide. Strict lifestyle modification can prevent the progression of complications associated with diabetes. There is much evidence to show that following a healthy lifestyle such as healthy diet, moderate weight loss, and doing regular exercise can maintain normal blood glucose levels and minimize diabetes-related complications. Moreover, this lifestyle modification has a great impact on the control of hyperglycemia. Good knowledge, positive attitude, and good practice towards lifestyle modification can help to maintain a normal blood glucose level. Objective: The aim was to assess knowledge, attitude, and practice towards lifestyle modification of diabetes patients attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. Methods: An institutional-based crossectional study was conducted among diabetes patients attending chronic follow-up clinic from November 15, 2019 to December 15, 2019. Study participants were selected using a systematic random sampling technique. Data were collected by using a structured questionnaire and analyzed using the statistical package for social science version 20. Descriptive statistics were computed to determine the knowledge, attitude, and practice of diabetes patients toward lifestyle modification. Results: A total of 422 participants took part in this study with a response rate of 100%. In this study, 248 (59%) were knowledgeable, 223 (53%) had a positive attitude, and 172 (41%) had good practice, respectively. Conclusion: The findings of this study showed that the knowledge and attitude toward lifestyle modification were found to be good. However, the result of practice of lifestyle modification was low. Recommendation: Education about the disease condition and lifestyle modification (importance of physical exercise, weight loss, foot care, cessation of smoking, healthy dietary habit) to general society ought to be implemented by the responsible body.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

<p>Knowledge, Attitude, and Practice Toward Lifestyle Modification Among Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital Northwest, Ethiopia</p>

Mekonnen

Abate

Tegegne

2020

DMSO

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“…Currently, Egypt is ranked first, with the largest number of patients with diabetes in the Middle East and North Africa region 3 . By 2045, the number of diabetes patients in Egypt is predicted to be doubled from 8.2 million to 16.7 million 4 . Many factors, including obesity, unhealthy lifestyles, and family history could be the reasons behind the increased prevalence of DM in Egypt 5 .…”

Section: Introductionmentioning

confidence: 99%

The influence of SLC22A1 rs622342 and ABCC8 rs757110 genetic variants on the efficacy of metformin and glimepiride combination therapy in Egyptian patients with type 2 diabetes

Ebid

Ehab

Ismail³

et al. 2019

Journal of Drug Assessment

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Background: The incidence of Type 2 Diabetes Mellitus (T2DM) in Egypt is considered one of the highest in the world. Metformin and Sulfonylureas are usually prescribed together due to their efficacy and their relatively low cost. Organic cation transport 1, encoded by SLC22A1 gene, is the main transporter of metformin into hepatocytes, which is considered metformin site of action. Sulfonylureas enhance insulin release from pancreatic B- cells through binding to sulfonylurea receptor 1, encoded by ABCC8 gene. Single nucleotide polymorphisms in the SLC22A1 and ABCC8 genes might affect the response of each drug. Aims: To investigate the influence of SLC22A1 rs622342 (A>C) and ABCC8 rs757110 (A>C) genetic variants on the efficacy of metformin and glimepiride combination therapy in Egyptian T2DM patients. Methods: Observational cross-sectional study in which patients receiving metformin and glimepiride combination therapy for at least 6 months were included for genotyping and classified into either responders or non-responders, based on their HbA1C level. Results: A total of 127 patients were included and genotyped. They were divided into 93 responders (HbA1C<7%) and 34 non-responders (HbA1C≥7%). Minor allele frequencies for rs622342 and rs757110 were 0.189 and 0.271, respectively. Only SLC22A1 rs622342 variant was found to be associated with the response of combination therapy, in which AA alleles carriers were 2.7-times more responsive to metformin than C allele carriers (Recessive model, odds ratio = 2.718, p = 0.025, 95% CI = 1.112–6.385). Conclusion: Genotyping of rs622342 can be useful in predicting the response to metformin in combination therapy in Egyptian T2DM patients.

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“…Egypt occupies the 8 th ranks regarding the prevalence of diabetes. The estimated prevalence of diabetes in Alexandria, Egypt was 16.8% in 2018 [2]. The main pathogenic mechanism of T2DM is insulin resistance that results in relative insulin deficiency [1].…”

Section: Introductionmentioning

confidence: 99%

Serum leptin level and microvascular complications in type 2 diabetes

Aaty

Rezk

Megallaa

et al. 2020

Clinical Diabetology

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Background. Type 2 diabetes (T2DM) and its complications are highly prevalent in Egypt and are considered a major health problem. Insulin resistance arising from visceral obesity is the main pathological mechanism of T2DM. Leptin is an adipokine secreted from visceral adipose tissue and its level is proved to be higher in patients with T2DM, but its association with microvascular complications is not yet well-established, for this aim the present study was conducted. Methods. This cross-sectional study was conducted among 120 participants with T2DM recruited from the diabetes outpatient clinic of Alexandria Main University Hospital, Alexandria, Egypt. Each participant was subjected to full history taking, complete physical examination and laboratory investigations. Results. Serum leptin level was significantly positively correlated with diabetes duration, BMI, WC, systolic and diastolic blood pressure, FPG, HbA 1c , serum insulin level, HOMA-IR, total cholesterol, triglycerides and LDL-C. Regarding microvascular complications, serum leptin level was highly significantly positively correlated with UACR, peripheral neuropathy and retinopathy

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Prevalence of type 2 diabetes mellitus in a sample of the adult population of Alexandria, Egypt

Cited by 30 publications

References 24 publications

<p>Knowledge, Attitude, and Practice Toward Lifestyle Modification Among Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital Northwest, Ethiopia</p>

<p>Knowledge, Attitude, and Practice Toward Lifestyle Modification Among Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital Northwest, Ethiopia</p>

The influence of SLC22A1 rs622342 and ABCC8 rs757110 genetic variants on the efficacy of metformin and glimepiride combination therapy in Egyptian patients with type 2 diabetes

Serum leptin level and microvascular complications in type 2 diabetes

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