Prevalence of type-2 diabetes and prediabetes in Malaysia: A systematic review and meta-analysis

Akhtar, Sohail; Nasir, Jamal Abdul; Ali, Aqsa; Asghar, Mubeen; Majeed, Rizwana; Sarwar, Aqsa

doi:10.1371/journal.pone.0263139

Cited by 53 publications

(44 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PRISMA Guidelines ( 15 ) were followed in this study. Similarly, to our previous studies ( 16 – 18 ), two of us (S.A. and F.H.) identified articles on the prevalence of diabetic foot ulcers in Pakistan published from inception to August 10, 2022.…”

Section: Methodsmentioning

confidence: 91%

The prevalence of foot ulcers in diabetic patients in Pakistan: A systematic review and meta-analysis

Akhtar

Ali²,

Ahmad³

et al. 2022

Front. Public Health

Self Cite

View full text Add to dashboard Cite

We aimed to determine the pooled prevalence of diabetic foot ulcers in Pakistan. MEDLINE (PubMed), Web of Science, Google scholars, and local databases were systematically searched for studies published up to August 10, 2022, on the prevalence of foot ulcers among diabetic patients in Pakistan. Random-effects meta-analysis was used to generate summary estimates. Subgroup analysis and meta-regression models were used to address the issue of high heterogeneity. Two authors independently identified eligible articles, collected data, and performed a risk of bias analysis. Twelve studies were included in the meta-analysis (14201, range 230–2199, diabetic patients), of which 7 were of “high” quality. The pooled prevalence of diabetic foot ulcers was 12.16% (95% CI: 5.91–20.23%). We found significant between-study heterogeneity (I2 = 99.3%; p < 0.001) but no statistical evidence of publication bias (p = 0.8544). Subgroup meta-analysis found significant differences in foot ulcer prevalence by publication year and by the duration of diabetes. An increasing trend was observed during the last two decades, with the prevalence of diabetic foot ulcers being the highest in the latest period from 2011 to 2022 (19.54%) than in the early 2000 s (4.55%). This study suggests that the prevalence of diabetic foot ulcers in Pakistan is relatively high, with significant variation between provinces. Further study is required to identify ways for early detection, prevention, and treatment in the population.

show abstract

Section: Methodsmentioning

confidence: 91%

The prevalence of foot ulcers in diabetic patients in Pakistan: A systematic review and meta-analysis

Akhtar

Ali²,

Ahmad³

et al. 2022

Front. Public Health

Self Cite

View full text Add to dashboard Cite

show abstract

“…According to the 2019 National Health and Morbidity Survey (NHMS) report, the prevalence of DM in Malaysia has increased from 11.2% in 2011 to 13.4% in 2015 and 18.3% in 2019 [ 36 ], meaning that almost one in five Malaysian adults has diabetes. By 2025, seven million Malaysian adults are likely to have diabetes—an alarming trend that will lead to a diabetes prevalence of 31.3% among adults aged ≥18 years [ 37 ]. This has serious implications for the healthcare and social system and the national economy.…”

Section: Introductionmentioning

confidence: 99%

Health insurance status and its determinants among patients with type 2 diabetes mellitus in a tertiary teaching hospital in Malaysia

et al. 2022

View full text Add to dashboard Cite

Introduction Even in a country with a tax-based healthcare financing system, health insurance can play an important role, especially in the management of chronic diseases with high disease and economic burden such as Type 2 Diabetes Mellitus (T2DM). The insurance coverage among T2DM patients in Malaysia is currently unclear. The aim of this study was to determine the insurance status of T2DM patients in public and private healthcare facilities in Malaysia, and the association between this status and patients’ sociodemographic and economic factors. Methods A cross-sectional study among T2DM patients seeking inpatient or outpatient treatment at a public tertiary hospital (Hospital Canselor Tuanku Muhriz) and a private tertiary hospital (Universiti Kebangsaan Malaysia Specialist Centre) in Kuala Lumpur between August 2019 and March 2020. Patients were identified via convenience sampling using a self-administered questionnaire. Data collection focused on identifying insurance status as the dependent factor while the independent factors were the patients’ sociodemographic characteristics and economic factors. Results Of 400 T2DM patients, 313 responded (response rate, 78.3%) and 76.0% were uninsured. About 69.6% of the respondents had low monthly incomes of <RM5000. Two-thirds of participants (59.1%) spent RM100–500 for outpatient visits whilst 58.5% spent <RM100 on medicines per month (RM1 = USD0.244). Patients who visited a private facility had five times more likely to have insurance than patients who visited a public facility. Participants aged 18–49 years with higher education levels were 4.8 times more likely to be insured than participants aged ≥50 years with low education levels (2 times). Conclusions The majority of T2DM patients were uninsured. The main factors determining health insurance status were public facilities, age of ≥ 50 years, low education level, unemployment, and monthly expenditure on medicines.

show abstract

“…In today's world, diabetes mellitus is considered as one of the main threats to public health, and its prevalence has been increasing in recent decades in developed and developing countries (Akhtar et al, 2022). A report by the International Federation of Diabetes (IDF) in 2019 showed that 9.3% of the world's adults had diabetes.…”

Section: Introductionmentioning

confidence: 99%

The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain‐derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double‐blind, placebo‐controlled trial

Bazyar

Zaman

Javid

2022

Phytotherapy Research

View full text Add to dashboard Cite

This study aimed to investigate the effects of rutin flavonoid in type 2 diabetes mellitus (T2DM) patients. In this trial (double‐blind, placebo‐controlled), 50 T2DM patients (supplement, n = 25 and placebo, n = 25) were randomized and supplemented with 500 mg rutin or placebo per day for 3‐months. At the beginning and at the end of the study, metabolic parameters including fasting blood glucose (FBG), insulin, glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMO‐IR), quantitative insulin sensitivity check index (QUICKI), homeostasis model assessment of β‐cell function (HOMA‐β), triglyceride (TG), total cholesterol (CHOL), high‐density and low‐density lipoprotein cholesterol (HDL‐c and LDL‐c), and atherogenic index of plasma (AIP), inflammatory and oxidative stress markers such as interleukin 6 (IL‐6), total antioxidant capacity (TAC), and malondialdehyde (MDA) and brain‐derived neurotrophic factor (BDNF) were assessed. The results showed a significant decrease in FBG, insulin, HbA1c, HOMO‐IR, LDL‐c, TG, VLDL, CHOL, LDL‐c.HDL‐c ratio, AIP, IL‐6, and MDA and a significant increase in HDL‐c, QUICKI index, BDNF, and TAC compared with the initial value (p for all <.05). In the adjusted model, the mean changes of FBG, insulin, HbA1c, HOMO‐IR, LDL‐c, CHOL, LDL.HDL ratio, AIP, MDA, and IL‐6 were significantly lower and mean changes of QUICKI index, HDL‐c, and TAC were significantly higher in the rutin group compared with the placebo group (adjusted p for all <.05). It seems that rutin may have beneficial effects on improving metabolic parameters, BDNF, and inflammatory and oxidative stress factors in T2DM patients.

show abstract

Prevalence of type-2 diabetes and prediabetes in Malaysia: A systematic review and meta-analysis

Cited by 53 publications

References 27 publications

The prevalence of foot ulcers in diabetic patients in Pakistan: A systematic review and meta-analysis

The prevalence of foot ulcers in diabetic patients in Pakistan: A systematic review and meta-analysis

Health insurance status and its determinants among patients with type 2 diabetes mellitus in a tertiary teaching hospital in Malaysia

The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain‐derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double‐blind, placebo‐controlled trial

Contact Info

Product

Resources

About