Prevalence of Treponema Pallidum Antibody among Volunteer Blood Donors in China

Abstract

Background. Infection with syphilis is still a major public health problem. The precise data for syphilis seroprevalence in the populations will help to develop a strategy for prevention and treatment of it. However, the data for syphilis prevalence in continuous years among volunteer blood donors in China is rare. Methods. A retrospective study for Treponema pallidum (TP) antibody in blood donors was conducted from January 2010 to December 2019 at the Blood Center of Zhejiang Province, China. TP antibody was detected with two different reagents using enzyme-linked immunosorbent assay and the only sample which was reactive in the two reagents was defined as seropositive. Results. A total of 992,646 volunteer blood donors were analyzed and the positive rate of TP antibody in the blood donors was 0.43%. From 2010 to 2019, the positive rates of TP antibody were 0.53%, 0.51%, 0.51%, 0.43%, 0.36%, 0.18%, 0.11%, 0.12%, 0.11%, and 0.10%, respectively. The positive rates of TP antibody were significantly different among blood donor age group ( p < 0.001 ), with the highest positive rate in 45–54-years-old group (0.93%). The positive rates of TP antibody in male and female blood donors were 0.44% and 0.41%, respectively. The positive rate was 0.57% among the first-time blood donors, which was significantly higher than that of the repeat blood donors (0.17%). The positive rate of TP antibody in blood donors decreased gradually with the increase of educational level. Conclusion. The syphilis seroprevalence is low in the blood donors of the Hangzhou area, and the positive rate of blood donors is associated with age, educational level, and times of blood donation. Increasing the number of repeat blood donations is helpful to improve blood safety.

Epidemiology of Syphilis Among Blood Donors in Brazzaville, Republic of Congo

“…In this study, the rate of T. pallidum antibody positivity decreased with increasing level of education. In similar studies performed by Singhal et al, in India and Zheng et al, in China [17,19], the percentage of syphilis was highest in uneducated donors, while the lowest was observed in graduates. This phenomenon may be linked to the fact that when the level of education is relatively high, the rate of awareness of health knowledge is relatively high and the risk of infection is low.…”

Prevalence and Residual Risk of HIV in Volunteer Blood Donors of Zhejiang Province, China, from 2018 to 2022

“…Te samples of the blood donors from the original 12 blood services were centralized for NAT in four blood services (Hangzhou, Ningbo, Jinhua, and Wenzhou) [11]. Additionally, a unifed blood information management system has been established for all blood services, facilitating comprehensive analysis of all blood donors' information in the Zhejiang Province [11,26,27]. Tis study retrospectively analyzes the HIV testing results of all blood donors in the Zhejiang Province over the past 5 years based on a large size of samples using the blood information management system, which will help improve blood donor recruitment strategy and HIV prevention and control strategies.…”

Prevalence and residual risk of HIV in volunteer blood donors of Zhejiang Province, China from 2018 to 2022

“…In most cases, serology test and NAT are preformed in the same blood services in China, but centralized NAT was implemented in Zhejiang Province,China from 2016 [11,25]. The samples of the blood donors from the original 12 blood services were centralized for NAT in four blood services( Hangzhou, Ningbo, Jinhua, and Wenzhou) [11].In additional, a uni ed blood information management system has established for all blood services in the Zhejiang Province, which facilitates comprehensive analysis of all blood donors information in the Zhejiang Province [11,25,27]. In this study, we retrospectively analyze the HIV testing results of all blood donors in the Zhejiang Province over the past 5 years based on a large size of samples using the blood information management system,which will help improving blood donors recruitment strategy and improving HIV prevention and control strategies.…”