Prevalence of Transfusion Transmitted Virus Infection and its Effect on Renal Graft Survival in Renal Transplant Recipients

Usta, Mehmet; Dilek, Kamıl; Ersoy, Alpaslan; Özdemi̇r, Bülent; Mıstık, Reşit; Vuruşkan, Hakan; Güllülü, Mustafa; Yavuz, Mahmut; Oktay, Bülent; Yurtkuran, Mustafa

doi:10.1080/003655902762467657

Cited by 10 publications

(8 citation statements)

References 19 publications

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“…A possible contribution of TTV to the immune impairment of patients with AIDS or other immunocompromising conditions has also been suggested 60, 98–103. In addition, the observation that anelloviruses often circulate in blood in the form of immune complexes and replicate in proliferating lymphoid cells has led to investigate a possible involvement of TTV and TTMV in certain kidney and hematological illnesses 41, 45, 73, 82, 104–108.…”

Section: Anelloviruses and Diseasementioning

confidence: 99%

Human anelloviruses and the central nervous system

Maggi

Bendinelli

2010

Reviews in Medical Virology

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Torque teno virus and related anelloviruses are a recent addition to the list of agents that cause chronic productive infections and high levels of plasma viraemia in humans. Many aspects of the natural history and pathogenesis of these under many respects surprising viruses are still poorly understood. In this review, we briefly outline the general properties of anelloviruses, examine what is currently known about the interactions they establish with the central nervous system (CNS), and discuss the possible pathological consequences.

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Section: Anelloviruses and Diseasementioning

confidence: 99%

Human anelloviruses and the central nervous system

Maggi

Bendinelli

2010

Reviews in Medical Virology

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“…In multicenter tests performed in the United States in 3078 organ donors, anti‐HCV antibodies were discovered in 4.2% of subjects using the ELISA second‐generation test, while HCV RNA was found in 2.4% of subjects using the PCR method 78 . The occurrence of anti‐HCV antibodies within this group depends on the geographic region, method of kidney‐substitutive treatment, hemodialysis duration, number of blood transfusions, and number of transplantations 79,80 . It is estimated that about 10% to 41% of patients have anti‐HCV antibodies after renal transplantation 79 .…”

Section: Hcv Infection In Kidney Transplant Recipientsmentioning

confidence: 99%

Hepatitis C virus infection in dialysis patients

Sułowicz

Radziszewski

Chowaniec

2007

Hemodialysis International

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Hepatitis C virus (HCV) infection is a global health problem, common worldwide, leading to acute and chronic hepatitis and its consequences of hepatocirrhosis and hepatocellular carcinoma. Patients on hemodialysis belong to the high-risk group of HCV infection. The prevalence of HCV infection in dialysis patients ranges from 4% to more than 70% in some countries. The main reasons for such a high incidence of infections are a high prevalence of HCV infection in the general population, lack of standard infection precautions and effective vaccination, inadequate disinfection procedures of dialysis machines and other medical equipment, as well as spread of infection from patient to patient, especially in dialytic centers with a high percentage of infected patients. The diagnostic procedures useful in the evaluation of HCV infection are detection of anti-HCV antibodies, identification of HCV RNA, counts of virus copies, and identification of its genome. From the 6 major genotypes and multiple subtypes of the HCV, genotypes 1a and 1b are the most common in Europe and Japan, and 1b is responsible for more severe liver disease and aggressive course leading to liver fibrosis. Antiviral therapy of HCV+ dialysis patients with interferon-alpha (INF-alpha) gives slightly better results than in the general population, but is poorly tolerated and associated with side effects. Although ribavirin in not recommended for dialysis patients, the addition of small doses of this compound to pegylated INF is discussed, especially for patients in whom previous infection treatment failed.

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“…Usta ve ark. [28] yaptıkları bir çalışmada TTV DNA renal transplant hastalarında %51,5 oranında pozitif saptanmış ve bu sonuç sağlıklı kontrol grubuna göre (%7) istatistiksel olarak oldukça anlamlı bulunmuştur. Aynı çalışmada TTV'nin renal graft reddine önemli bir etkisi olmadığı, herhangi bir karaciğer hasarı oluşturmadığı bildirilmiş; kan transfüzyon hızı, toplam diyaliz süresi ya da transplant sonrası sürelere bakıldığında TTV pozitif ve negatif hastalar arasında anlamlı bir farklılık saptanmamıştır.…”

Section: Discussionunclassified

The seroprevalance of hepatitis E, hepatitis G and TTV in haemodialysis patients

et al. 2017

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ÖzAmaç: Hemodiyaliz hastaları kan, kan ürünleri, perkütan yaralanma veya fekal-oral yolla bulaşabilen hepatit virüs-leri açısından risk grubunda yer alır. Bu çalışmada, hemodiyaliz hastalarında Hepatit E, Hepatit G ve TTV seropozitifliğinin belirlenmesi amaçlandı. Gereç ve Yöntemler:Çalışmaya 66 hemodiyaliz hastası (30 kadın, 36 erkek) ve 66 kontrol (43 kadın, 23 erkek) olmak üzere toplam 132 kişi dahil edildi. Çalışmada anti-HEV, anti HGV ve anti-TTV IgG düzeyleri ELISA yöntemi ile çalışıldı. İstatistiksel analizler SPSS programı ile yapıldı. Elde edilen sonuçların istatistiksel değerlendirilme-sinde Students t testi, Fischer exact testi ve Mann Whitney-U testleri kullanıldı. P < 0.05 değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Çalışmaya alınan 66 hasta ve 66 sağlıklı kontrol grubunun yaş ortalaması sırasıyla; 54,9 ve 47,2 idi. Hasta ve kontrol grubunun yaş ortalaması karşılaştırıldığında hasta grubunun yaş ortalaması daha yüksekti.Anti-TTV IgG ve anti-HEV IgG pozitifliği hemodiyaliz hastalarında kontrol grubuna göre daha yüksek bulundu. Hasta ve kontrol grubunda anti-HGV IgG pozitifliği tespit edilmedi. Hemodiyaliz hasta grubunda anti-TTV IgG ve anti-HEV IgG pozitifliği ile hemodiyaliz süresi, yaş ve cinsiyet arasında istatistiksel olarak anlamlı bir ilişki saptanmadı.Sonuç: Hemodiyaliz hastaları, TTV, hepatit E virüsü ve diğer hepatit virüslerinin bulaşı açısından yüksek risk taşırlar. Bu nedenle, hemodiyaliz ünitelerde temizlik ve dezenfeksiyon kurallarına uyulması HEV ve TTV gibi hepatit virüslerinin bulaşını önlemek için gereklidir.

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Prevalence of Transfusion Transmitted Virus Infection and its Effect on Renal Graft Survival in Renal Transplant Recipients

Cited by 10 publications

References 19 publications

Human anelloviruses and the central nervous system

Human anelloviruses and the central nervous system

Hepatitis C virus infection in dialysis patients

The seroprevalance of hepatitis E, hepatitis G and TTV in haemodialysis patients

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