Prevalence of transfusion transmitted infections amongst multiple blood transfused patients of β-thalassemia major in a tertiary care hospital

Mittal, Kundan; Abrol, Pankaj; Yadav, Jaivinder

doi:10.18203/2320-6012.ijrms20164545

Cited by 9 publications

(8 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Frequent blood transfusions increase the risk of TTI transmission. This was in concordance with the findings of Atwa and Abdel Wahed,[ 10 ] Mansour et al ,[ 21 ] Bhavsar et al [ 25 ] and Mittal et al [ 14 ] which found out the frequency of blood transfusion as an important determinant of TTIs. However, there are contrary evidence too, reported by Mahmoud et al [ 15 ] and Biswas et al [ 16 ] The variability of findings may be due to their small sample sizes compared to us.…”

Section: Discussionsupporting

confidence: 92%

“…Table 5 shows the burden of TTIs as reported by various studies and the current study. In our study, 34.5% of study participants were anti-HCV positive which was concurrent to findings of Mittal et al [ 14 ] (35.5%) and Mahmoud et al [ 15 ] (37.1%). There were studies which reported more[ 9 21 ] and vice versa[ 10 16 17 18 19 20 22 23 24 25 ] compared to our study.…”

Section: Discussionsupporting

confidence: 91%

“…In our study with increase in age chances of TTIs also increased which was similar to the findings of Atwa and Abdel Wahed,[ 10 ] Mahmoud et al ,[ 15 ] Mansour et al ,[ 21 ] and Kiani et al ,[ 18 ] but unlike the findings of Din et al [ 9 ] and Mittal et al [ 14 ] which failed to show any such association. Similarly, we also found that with the increase in age at the diagnosis the chances of getting TTI also reduces which was in concordance with the findings of Atwa and Abdel Wahed[ 10 ] and Mahmoud et al [ 15 ] which reported that with the increase in the duration of illness chances of TTIs increases.…”

Section: Discussionsupporting

confidence: 90%

See 2 more Smart Citations

Transfusion-transmitted infections, its risk factors and impact on quality of life: An epidemiological study among β-thalassemia major children

Biswas¹,

Naskar²,

Basu³

et al. 2022

Asian J Transfus Sci

View full text Add to dashboard Cite

BACKGROUND: Multi-transfused thalassemic children are at higher risk of acquiring transfusion-transmitted infections (TTIs). There are limited data available on TTIs among thalassemic children, especially on its impact on their quality of life (QoL). AIM: The aim of this study is to find out the proportion of multi-transfused β-thalassemia major (β-TM) children suffering from TTIs, its risk factors and impact on QoL. METHODS: This was a hospital-based, analytical observational study, cross-sectional in design, conducted among 328 β-TM children and their caregivers attending thalassemia day care unit of a medical college during May 2015–April 2016, with a structured schedule. Data were analyzed with appropriate statistical methods using the Statistical Package for the Social Sciences. RESULTS: Two-fifth (39.9%) of them were found to have TTIs with hepatitis C being the most common (34.5%), followed by hepatitis B (4.5%) and human immunodeficiency virus (1.8%). In the multivariable model, place of residence (adjusted odds ratio [AOR] – 2.23 [1.19–4.17]), per capita monthly family income (AOR – 1.84 [1.10–3.07]), and blood transfusion frequency (AOR – 1.19 [1.10–1.29]) were significant predictors of TTIs adjusted with their age, age at diagnosis, last pretransfusional hemoglobin level, size of spleen, and caregivers knowledge regarding the disease. The study participants with TTIs had a lower QoL compared to others as there were significant differences in between the total QoL scores ([49.9 ± 15.6 vs. 57.4 ± 15.5], P ≤ 0.001) and its various domains. CONCLUSION: There was high burden of TTIs among multi-transfused β-TM children and it has significant negative impact on their quality of lives.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Transfusion-transmitted infections, its risk factors and impact on quality of life: An epidemiological study among β-thalassemia major children

Biswas¹,

Naskar²,

Basu³

et al. 2022

Asian J Transfus Sci

View full text Add to dashboard Cite

show abstract

“…This finding is comparable to other studies. 4,6,7 In the study done by Mittal et al 14 , 66.6% of the patients who had received more than 400 blood transfusions were seropositive for Anti-HCV. There is a reduction in the development of anti-HCV post 2001, but it has not been eliminated.…”

Section: Discussionmentioning

confidence: 96%

Prevalence of Transfusion Transmitted Infections in Multiple Blood Transfused β-Thalassemia Patients from a Tertiary Care Centre in North India

Gugnani¹,

Oberoi²,

Arora³

2019

IJCMR

View full text Add to dashboard Cite

Introduction: The mainstay of therapy for patients suffering from beta thalassemia major is regular blood transfusion and chelation therapy due to constraints in bone marrow transplantation. The present study was conducted to estimate the prevalence of transfusion-transmitted infections (TTIs) in multitransfused patients of thalassemia major and to determine the association with relation to the number of blood transfusions received. Material and Methods: This study was conducted in Department of Microbiology on 126 β-thalassemia major patients registered for regular blood transfusions at Thalassemia Day Care Centre attached to Department of Pediatrics, Government Medical College, Amritsar, Punjab from January to July 2018. The patient's serum samples were screened for TTIs i.e. Human Immunodeficiency Virus (HIV), Hepatitis B virus (HBV) and Hepatitis C virus (HCV). Seropositivity screening for HBV and HCV was done by rapid Immunochromatographic test and confirmed by enzymelinked immunosorbent assays. (ELISA) while for HIV as per NACO guidelines. Results: Out of 126 patients, 14.28% (18/126) were seroreactive for TTIs. Of these sero-reactive patients, 13.4% (17/126) were positive for anti-HCV antibody, 0.79% (1/126) positive for HBsAg and none (0) for anti HIV antibody. Of the anti-HCV reactive cases, 70.5% (12 out of 17) were >12years of age, 58.8% (10 out of 17) had received more than 250 transfusions, and 23.5% (4 out of 17) had received transfusions between 100 to 250. Anti-HCV seroreactivity was thus found to increase with the age and increase in the number of transfusions received. Conclusion: It is concluded that HCV is the most prevalent TTI in multi-transfused children with thalassemia major and stringent pre-transfusion screening of blood for anti-HCV must be introduced in blood centers. HBV vaccination should also be done before the start of transfusion regimen or as soon as possible after diagnosis of thalassemia.

show abstract

“…Blood transfusion practices challenge the life of thalassemia patients and can cause new medical problems such as transfusion-transmitted infections like HCV, HBV, HIV, and syphilis infections. 7 , 8…”

Section: Introductionmentioning

confidence: 99%

Prevalence of transfusion-transmitted infections in multiple blood transfusion-dependent thalassemic patients in Asia: A systemic review

Riaz

Abbas

Rasool

et al. 2022

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Background Thalassemia is a hereditary hemolytic anemia marked by a defect in synthesizing one or more globin chains in hemoglobin. In Pakistan, approximately 10,000 patients with thalassemia are primarily dependent on blood transfusions. The β-thalassemia patients require blood transfusions and iron chelation therapy. Patients who need blood transfusions are at an increased risk of contracting transfusion-transmitted infections (TTIs) such as hepatitis B and C viruses (HBV and HCV, respectively), as well as the human immunodeficiency virus (HIV). Objective This systemic review aims to assess the prevalence of TTIs in transfusion-dependent β-thalassemia patients in Asia. Methods The data for the systematic review were gathered from PubMed, Google Scholar, the Directory of Open Access Journals (DOAJ), and ScienceDirect using the following keywords: “prevalence, HBV, HCV, HIV, thalassemia, and transfusion-transmitted infections (TTIs)," and so on. This review includes the research articles that address the prevalence of viral infections in thalassemic patients following blood transfusion. Results A preliminary search of various databases identified 231 potential studies. 157 duplicate studies were eliminated, and the eligibility of 59 full-length articles was determined. Only 43 studies met the inclusion criteria. Among the 43 studies analyzed, 11 reported a high prevalence of HCV alone in thalassemic patients, while 21 reported a high prevalence of HCV and HBV infection in thalassemic patients. Eight studies reported the prevalence of all three TTIs examined, namely, HCV, HBV, and HIV, in patients with transfusion-dependent thalassemia. Conclusion Preventable transfusion-transmitted infections occur frequently, and robust national policies and hemovigilance are required to detect and mitigate the infection risk.

show abstract

Prevalence of transfusion transmitted infections amongst multiple blood transfused patients of β-thalassemia major in a tertiary care hospital

Cited by 9 publications

References 1 publication

Transfusion-transmitted infections, its risk factors and impact on quality of life: An epidemiological study among β-thalassemia major children

Transfusion-transmitted infections, its risk factors and impact on quality of life: An epidemiological study among β-thalassemia major children

Prevalence of Transfusion Transmitted Infections in Multiple Blood Transfused β-Thalassemia Patients from a Tertiary Care Centre in North India

Prevalence of transfusion-transmitted infections in multiple blood transfusion-dependent thalassemic patients in Asia: A systemic review

Contact Info

Product

Resources

About