Prevalence of thyroid dysfunction and its impact on cognition in older mexican adults: (SADEM study)

Juárez‐Cedillo, Teresa; Basurto-Acevedo, Lourdes; Vega-García, Sara; Martha, A Sánchez-Rodríguez; Retana-Ugalde, Raquel; Juárez‐Cedillo, Enrique; Roberto, C Gonzalez-Melendez; Escobedo, Jorge

doi:10.1007/s40618-017-0654-6

Cited by 38 publications

(20 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 6 Without correction, patients with abnormal thyroid results may have an increased risk of cardiovascular disease, dysrhythmias and fractures, 7 and are at risk of adverse effects on bone mass, 8 lipid metabolism, 9 blood pressure 10 and cognitive function. 11 12 Even variation in thyroid function within the normal population reference range may also be associated with important differences in key health outcomes. 13 14 Furthermore, neglected hypothyroidism can result in life-threatening myxoedema coma.…”

Section: Introductionmentioning

confidence: 99%

Attitudes and perceptions of health professionals towards management of hypothyroidism in general practice: a qualitative interview study

et al. 2018

View full text Add to dashboard Cite

ObjectiveTo explore the attitudes and perceptions of health professionals towards management of hypothyroidism that contributes to the suboptimal treatment of hypothyroidism in general practice.DesignA qualitative interview study using semistructured interviews.ParticipantsSixteen participants were interviewed between March and August 2016 comprising nine general practitioners (GPs), four pharmacists, two practice nurses and one nurse practitioner.SettingGeneral practice and community pharmacies in the counties of Northumberland, Tyne and Wear, Stockton-on-Tees and North Cumbria, North of England, UK.MethodA grounded-theory approach was used to generate themes from interviews, which were underpinned by the theory of planned behaviour to give explanation to the data.ResultsAlthough health professionals felt that hypothyroidism was easy to manage, GPs and nurses generally revealed inadequate knowledge of medication interactions and levothyroxine pharmacokinetics. Pharmacists felt limited in the advice that they provide to patients due to lack of access to patient records. Most GPs and nurses followed local guidelines, and relied on blood tests over clinical symptoms to adjust levothyroxine dose. The information exchanged between professional and patient was usually restricted by time and often centred on symptoms rather than patient education. Health professionals felt that incorrect levothyroxine adherence was the main reason behind suboptimal treatment, although other factors such as comorbidity and concomitant medication were mentioned. Enablers perceived by health professionals to improve the management of hypothyroidism included continuity of care, blood test reminders, system alerts for interfering medications and prescription renewal, and accessible blood tests and levothyroxine prescriptions for patients.ConclusionThere is a significant health professional behavioural component to the management of hypothyroidism. Addressing the differences in patient and professional knowledge and perceptions could reduce the barriers to optimal treatment, while continuity of care and increased involvement of pharmacists and practice nurses would help to promote optimal thyroid replacement.

show abstract

Section: Introductionmentioning

confidence: 99%

Attitudes and perceptions of health professionals towards management of hypothyroidism in general practice: a qualitative interview study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In this way, our findings might support previous results showing the reduction of thyroid hormone in the blood [ 19 – 22 ]. Prevalence of thyroid dysfunction and its impact on cognition in older adults has been described [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase

Traina

Cataldi

Siccu

et al. 2017

Mediators of Inflammation

View full text Add to dashboard Cite

Prevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified. In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones. We have first investigated the changes of thyroid microstructure and the possibility that molecules involved in thyroid function might be associated with structural changes. Results from this study indicate changes in the height of the thyrocytes and in the amplitude of interfollicular spaces, anomalous expression/localization of thyrotropin, thyrotropin receptor, and thyroglobulin aging. Thyrotropin and thyrotropin receptor are upregulated and are distributed inside the colloid while thyroglobulin fills the interfollicular spaces. In an approach aimed at defining the behavior of molecules that change in different physiopathological conditions of thyroid, such as galectin-3 and sphingomyelinase, we then wondered what was their behavior in the thyroid gland in aging. Importantly, in comparison with the thyroid of young animals, we have found a higher expression of galectin-3 and a delocalization of neutral sphingomyelinase in the thyroid of old animals. A possible relationship between galectin-3, neutral sphingomyelinase, and aging has been discussed.

show abstract

“…It has also been known for some time that decreased thyroid hormone action in the CNS is detrimental while increased thyroid hormone action in the CNS correlates with clinical benefit in AD and other diseases of cognitive impairment. 44–50 Our finding that TREM2 is a thyroid hormone regulated gene whose expression is increased by T3 acting on TR in microglia suggests a mechanistic connection between elevated levels of T3 in the CNS and clinical benefit in AD and related disorders. The beneficial effect of increased T3 in the brain may in part relate to increased stimulation of TREM2 expression in microglia and increased activity through the TREM2 pathway.…”

Section: Discussionmentioning

confidence: 99%

TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor

Ferrara

Chaudhary

DeBell

et al. 2021

Preprint

View full text Add to dashboard Cite

Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor on macrophages and microglia that senses and responds to disease associated signals to regulate the phenotype of these innate immune cells. The TREM2 signaling pathway has been implicated in a variety of diseases ranging from neurodegeneration in the central nervous system to metabolic disease in the periphery. We report here that TREM2 is a thyroid hormone regulated gene and its expression in macrophages and microglia is stimulated by thyroid hormone. Both endogenous thyroid hormone and sobetirome, a synthetic thyroid hormone agonist drug, suppress pro-inflammatory cytokine production from myeloid cells including macrophages that have been treated with the SARS-CoV-2 spike protein which produces a strong, pro-inflammatory phenotype. Thyroid hormone agonism was also found to induce phagocytic behavior in microglia, a phenotype consistent with activation of the TREM2 pathway. The thyroid hormone antagonist NH-3 blocks the anti-inflammatory effects of thyroid hormone agonists and suppresses microglia phagocytosis. Finally, in a murine experimental autoimmune encephalomyelitis (EAE) multiple sclerosis model, treatment with Sob-AM2, a CNS-penetrating sobetirome prodrug, results in increased Trem2 expression in disease lesion resident myeloid cells which correlates with therapeutic benefit in the EAE clinical score and reduced damage to myelin. Our findings represent the first report of endocrine regulation of TREM2 and provide a unique opportunity to drug the TREM2 signaling pathway with orally active small molecule therapeutic agents.

show abstract

Prevalence of thyroid dysfunction and its impact on cognition in older mexican adults: (SADEM study)

Abstract: The present study demonstrated a high prevalence of thyroid dysfunction in Mexican elderly people living in the community. A relationship between cognitive impairment and the presence of hypothyroidism was also shown, and to a lesser degree in hyperthyroidism.

Cited by 38 publications

References 39 publications

Attitudes and perceptions of health professionals towards management of hypothyroidism in general practice: a qualitative interview study

Attitudes and perceptions of health professionals towards management of hypothyroidism in general practice: a qualitative interview study

Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase

TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor

Contact Info

Product

Resources

About