Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study

Sategna-Guidetti, C; Volta, Umberto; Ciacci, Carolina; Usai, Paolo; Carlino, A.; Franceschi, Lucia De; Camera, Andrea; Pelli, Anna; Brossa, C

doi:10.1111/j.1572-0241.2001.03617.x

Cited by 137 publications

(51 citation statements)

References 10 publications

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“…The occurrence of autoimmune thyroid disease in patients with known CD is well studied [5][6][7], but the occurrence of CD among autoimmune thyroid disorders is less well documented, especially in childhood. Previous studies reported that the frequency of CD in adults with AT varies from 3.2% to 3.4% [10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…An association between CD and other autoimmune disease such as type 1 diabetes mellitus, pernicious anemia, and Addison's disease has been reported [1][2][3][4]. The occurrence of autoimmune thyroid disorders among patients with CD is also well documented in pediatric and adult patients [5][6][7], but the prevalence of CD in patients with thyroid autoimmunity is as yet unclear, especially in children.…”

Section: Introductionmentioning

confidence: 95%

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Prevalence of Celiac Disease in Turkish Children with Autoimmune Thyroiditis

et al. 2008

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The close association between celiac disease (CD) and autoimmune disorders is well documented in adult and pediatric patients. The aim of this study is to determine the prevalence of CD in Turkish children with autoimmune thyroiditis (AT). Sera from 101 children with AT (11 boys and 90 girls, from 2 to 18 years of age; mean age 12.28 +/- 3.26 years) and 103 healthy children (46 boys and 57 girls, from 3.5 to 17 years of age; mean age 12.18 +/- 3.11 years) were screened for CD using the IgA anti-tissue transglutaminase (IgA anti-tTG) antibody and total serum IgA. Small intestinal biopsy was offered to all antibody-positive patients. IgA anti-tTG was positive in eight children (7.9%) with AT. None of the serum samples of healthy children were positive for IgA anti-tTG antibody. Selective IgA deficiency was not detected in patients or controls. Intestinal biopsy was accepted by seven patients. In five patients (4.9%), subtotal villous atrophy was found. These findings indicate that the prevalence of CD is higher in Turkish children with AT than in healthy controls. Routine screening for CD should be performed in children with AT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Prevalence of Celiac Disease in Turkish Children with Autoimmune Thyroiditis

et al. 2008

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“…In a subset of individuals with data on SEI we adjusted for SEI. We also adjusted for the following disorders because they are associated with an increased risk of both CD and fractures and therefore constitute potential confounders: thyroid disorders, 27, 28 diabetes mellitus 13, 29 and depression 30, 31 . We did not adjust for hyperparathyroidism because high levels of parathyroid hormone are often caused by CD itself 32 .…”

Section: Methodsmentioning

confidence: 99%

Coeliac disease and the risk of fractures – a general population‐based cohort study

Ludvigsson

Michaëlsson

Ekbom

et al. 2007

Aliment Pharmacol Ther

159

118

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“…Many studies confirm an increased prevalence of autoimmune (Hashimoto’s) thyroiditis and Graves disease within adult [26–31] and pediatric [28, 32]celiac populations. The converse also appears to be true CD is found in persons with autoimmune thyroid disorders at higher rates than the general population [31, 33–35].…”

Section: Celiac Disease and Thyroid Disordersmentioning

confidence: 99%

Celiac Disease and Autoimmunity: Review and Controversies

Denham

Hill

2013

Curr Allergy Asthma Rep

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Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. There is a strong linkage between CD and HLA-DQ2 and HLA-DQ8 haplotypes. Multiple case reports and small series suggest concordance between CD and other autoimmune disorders. This paper provides a brief overview of the pathogenesis of CD and reviews the literature regarding associations between CD and other autoimmune diseases, including the potential effects of gluten-free diet therapy on the prevention or amelioration of associated diseases.

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Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study

Abstract: The greater frequency of thyroid disease among celiac disease patients justifies a thyroid functional assessment. In distinct cases, gluten withdrawal may single-handedly reverse the abnormality.

Cited by 137 publications

References 10 publications

Prevalence of Celiac Disease in Turkish Children with Autoimmune Thyroiditis

Prevalence of Celiac Disease in Turkish Children with Autoimmune Thyroiditis

Coeliac disease and the risk of fractures – a general population‐based cohort study

Celiac Disease and Autoimmunity: Review and Controversies

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