Prevalence of thyroid antibodies in Nigerian patients

Okosieme, Onyebuchi; Taylor, Roberta; Ohwovoriole, A.E; Parkes, A. B.; Lazarus, John H.

doi:10.1093/qjmed/hcl137

Cited by 15 publications

(17 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, 80.6% patients were females. This compares with the study from Nigeria which found 77.9% of patients with thyroid disorders being females (6).…”

Section: Discussioncontrasting

confidence: 51%

“…As in this study, most of the patients in the study were in the 30 to 50 year age group. In a recent study among 104 patients with thyroid disorders in Nigeria, anti-TPOAbs were found in 60.5% of the patients (6).…”

Section: Discussionmentioning

confidence: 93%

“…It has been reported that thyroid autoimmunity is rare in iodine deficient areas but becomes more prevalent with improvement in iodine nutrition (6)(7)(8). Locally, it is a requirement that all domestic salt is iodinated in an attempt to reduce the occurrence of iodine deficiency disorders (9).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of Anti-Thyroid Antibodies in Patients with Primary Thyroid Disorders

Kuria

Amayo²

2008

E Af Med Jrnl

View full text Add to dashboard Cite

“…In this study, 80.6% patients were females. This compares with the study from Nigeria which found 77.9% of patients with thyroid disorders being females (6).…”

Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Prevalence of Anti-Thyroid Antibodies in Patients with Primary Thyroid Disorders

Kuria

Amayo²

2008

E Af Med Jrnl

View full text Add to dashboard Cite

“…34 In the preiodization era, a typical case of HT was described as having scanty or absent colloid. Iodineinduced thyroiditis is known to be associated with residual goiter in endemic areas under iodine prophylaxis.…”

Section: Cytomorphologic Analysis Of Ht and Its Serologic Correlationmentioning

confidence: 99%

Cytomorphologic Study of Hashimoto’s Thyroiditis and Its Serologic Correlation

et al. 2009

View full text Add to dashboard Cite

“…[11,12] Few studies have evaluated thyroid-antibody status in healthy African patients. [13][14][15][16][17][18] It is, however, known that thyroid-antibody levels decline progressively during pregnancy in healthy women without a thyroid disorder.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Analysis of Thyroid Disease in Pregnancy at Chris Hani Baragwanath Academic Hospital, Soweto, South Africa

et al. 2017

View full text Add to dashboard Cite

RESEARCHBackground. Thyroid diseases in pregnancy are associated with adverse outcomes for both mother and fetus. No studies have been reported examining the spectrum and nature of such disorders in the black population of South Africa. Objective. To examine thyroid disorders in pregnancy at Chris Hani Baragwanath Academic Hospital in Johannesburg, Soweto, by assessing the causes, management and outcomes. Methods. A retrospective review of thyroid disorders was undertaken in 88 patients attending the Antenatal Endocrine Clinic over a 4-year period. All underwent initial and follow-up clinical and biochemical assessments. Maternal delivery records and thyroid-function tests of the neonates ≥48 hours after delivery were reviewed. Results. A total of 58 pregnant women (66%) were hyperthyroid, 23 (26%) hypothyroid and 7 (8%) had euthyroid colloid goitres. Fortyeight (83%) hyperthyroid patients had Graves' disease, while 9 (16%) had gestational hyperthyroidism. Regarding the hypothyroid patients, more than half followed I131 ablation for Graves' disease. Overall, 87% of the hyperthyroid and 83% of the hypothyroid patients were euthyroid prior to delivery. One fatal maternal outcome, the result of uterine rupture, and six intra-partum fetal losses occurred. Amongst neonates, there was one case of a tracheo-oesophageal fistula and one of neonatal thyrotoxicosis. Conclusion. This is the first report in sub-Saharan Africa detailing thyroid diseases in pregnancy. Our findings add valuable epidemiological information to the paucity of data that has previously existed for thyroid disease in pregnancy in sub-Saharan Africa. S Afr J Obstet Gynaecol Corresponding author: V Nicolaou (docvic9@gmail.com)Over the past two decades, there have been several studies examining thyroid disorders in pregnancy, but none in South Africa. [1,2] The prevalence of hyperthyroidism is 0.1 -0.4% of all pregnancies in developed nations, with Graves' disease (GD) accounting for the majority of cases (85%). Hypothyroidism is estimated to occur in 2.3 -3.5% of pregnancies, of which overt hypothyroidism accounts for 0.3 -0.5%, and subclinical hypothyroidism for 2 -3% in iodinesufficient areas. [1,3] Data from a 2001 study demonstrated that more than one-third of South Africans are still iodine deficient, with endemic goiter being the most prevalent thyroid disorder. [4] The importance of thyroid disease in pregnancy is determined by the potential adverse outcomes of untreated disease for both mother and fetus. [5,6] While the diagnosis, evaluation and treatment are similar to those in the non-pregnant state, pregnancy poses its own unique challenges.Our study was carried out at Chris Hani Baragwanath Academic Hospital (CHBAH), Soweto, which is the largest hospital in Africa and serves a largely black population. We describe the underlying causes, management, control and outcomes of thyroid diseases in pregnancy. Methods Study populationWe reviewed 88 patients with a thyroid disorder who attended our Antenatal Endocrine Clinic from January 2004 to Ap...

show abstract

Prevalence of thyroid antibodies in Nigerian patients

Abstract: Thyroid autoimmunity appears more common in these Nigerian patients than in previous reports from Africa, and TPOAb was significantly associated with auto-immune thyroid disease. The clinical utility of these antibody measurements requires further evaluation in a wider African population.

Cited by 15 publications

References 17 publications

Prevalence of Anti-Thyroid Antibodies in Patients with Primary Thyroid Disorders

Prevalence of Anti-Thyroid Antibodies in Patients with Primary Thyroid Disorders

Cytomorphologic Study of Hashimoto’s Thyroiditis and Its Serologic Correlation

A Retrospective Analysis of Thyroid Disease in Pregnancy at Chris Hani Baragwanath Academic Hospital, Soweto, South Africa

Contact Info

Product

Resources

About