Prevalence of thoracic aortic calcification and its relationship to cardiovascular risk factors and coronary calcification in an unselected population-based cohort: the Heinz Nixdorf Recall Study

Kälsch, Hagen; Lehmann, Nils; Möhlenkamp, Stefan; Hammer, Cornelia; Mahabadi, Amir A.; Moebus, Susanne; Schmermund, Axel; Stang, Andreas; Bauer, Marcus; Jöckel, Karl‐Heinz; Erbel, Raimund

doi:10.1007/s10554-012-0051-3

Cited by 66 publications

(47 citation statements)

References 30 publications

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“…20,21 This stands in contrast to the Heinz-Nixdorf Recall Study, where ATAC was present in 43% of subjects. 22 Nonetheless, due to low ATAC prevalence, the findings of our study do not support widespread imaging of the ascending thoracic aorta. This was reflected in the marginal and non-significant increase in the AUC beyond that provided by both CVD risk factors and CAC when evaluated in the full cohort.…”

Section: Discussioncontrasting

confidence: 77%

Density of calcium in the ascending thoracic aorta and risk of incident cardiovascular disease events

et al. 2017

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Background and aims The volume and density of coronary artery calcium (CAC) both independently predict cardiovascular disease (CVD) beyond standard risk factors, with CAC density inversely associated with incident CVD after accounting for CAC volume. We tested the hypothesis that ascending thoracic aorta calcium (ATAC) volume and density predict incident CVD events independently of CAC. Methods The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective cohort study of participants without clinical CVD at baseline. ATAC and CAC were measured from baseline cardiac computed tomography (CT). Cox regression models were used to estimate the associations of ATAC volume and density with incident coronary heart disease (CHD) events and CVD events, after adjustment for standard CVD risk factors and CAC volume and density. Results Among 6811 participants, 234 (3.4%) had prevalent ATAC and 3395 (49.8%) had prevalent CAC. Over 10.3 years, 355 CHD and 562 CVD events occurred. One-standard deviation higher ATAC density was associated with a lower risk of CHD (HR 0.48 [95% CI 0.29–0.79], p<0.01) and CVD (HR 0.56 [0.37–0.84], p<0.01) after full adjustment. ATAC volume was not associated with outcomes after full adjustment. Conclusions ATAC was uncommon in a cohort free of clinical CVD at baseline. However, ATAC density was inversely associated with incident CHD and CVD after adjustment for CVD risk factors and CAC volume and density.

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Section: Discussioncontrasting

confidence: 77%

Density of calcium in the ascending thoracic aorta and risk of incident cardiovascular disease events

et al. 2017

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“…However, generally valve atherosclerosis is encountered earlier than coronary atherosclerosis 25. Atherosclerosis is a diffuse process that may affect different vascular beds with considerable overlap between coronary, cerebrovascular and peripheral arterial disease 26. It is possible that due to its early occurrence and the high prevalence of metabolic syndrome, the prevalence of AVC limits its discriminatory predictive power.…”

Section: Discussionmentioning

confidence: 99%

Beyond Framingham risk factors and coronary calcification: does aortic valve calcification improve risk prediction? The Heinz Nixdorf Recall Study

Kälsch

Lehmann

Mahabadi

et al. 2014

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“…reported that the aortic calcium score was associated with BMI, SBP, and pulse pressure. [36] A significant independent association between the total plaque score and MS was observed in males. [37] MS components are related to GD, and BMI and increased age are also related to GD.…”

Section: Discussionmentioning

confidence: 99%

The association between gallstone disease and plaque in the abdominopelvic arteries

et al. 2017

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Background:The aim of this study was to assess the atheromatous plaque, in the abdominopelvic arteries as a marker of cardiac risk in patients with or without gallstone disease (GD).Materials and Methods:A total of 136 patients were enrolled in this cross-sectional study. Forty-eight patients had GD and the remaining 88 patients did not. The presence or absence of gallstones was noted during abdominal ultrasonography while vascular risk factors such as plaque formation, intima-media thickness, plaque calcification, mural thrombus, stenosis, aneurysm, and inflammation were recorded during an abdominopelvic computed tomography scan. In addition, percentage of the abdominopelvic aorta surface covered by atheromatous plaque was calculated.Results:The mean age of patients with GD and without GD was 50.81 ± 16.20 and 50.40 ± 12.43, respectively. Patients with GD were more likely to have diabetes mellitus, a higher body mass index (BMI) (P < 0.001), and higher cholesterol (P < 0.01), and low-density lipoprotein-cholesterol (P < 0.02) levels. No significant differences were found between the groups regarding other atherosclerotic risk factors. Patients with GD had significantly higher rates of the vascular risk factors as intima-media thickness, plaque formation, calcification, aneurysm, mural thrombosis, stenosis, and inflammation in all abdominal arterial segments other than aneurysm in the femoral arteries. In addition, patients with GD had severe atheromatous plaques in the abdominal aorta, common iliac, external iliac, and common femoral artery (CFA). In patients with GD, parameters of age, BMI, and systolic and diastolic blood pressure were all correlated with the severity of the atheromatous plaque in abdominal aorta, common iliac, external iliac, and CFA.Conclusion:We demonstrated a direct relationship between GD and abdominopelvic atheromatous plaque, which is a marker for increased cardiovascular risk, for the first time in the literature. Patients with GD exhibit greater abdominopelvic atherosclerosis and therefore, have a higher risk of cardiovascular disease.

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Prevalence of thoracic aortic calcification and its relationship to cardiovascular risk factors and coronary calcification in an unselected population-based cohort: the Heinz Nixdorf Recall Study

Cited by 66 publications

References 30 publications

Density of calcium in the ascending thoracic aorta and risk of incident cardiovascular disease events

Density of calcium in the ascending thoracic aorta and risk of incident cardiovascular disease events

Beyond Framingham risk factors and coronary calcification: does aortic valve calcification improve risk prediction? The Heinz Nixdorf Recall Study

The association between gallstone disease and plaque in the abdominopelvic arteries

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