Prevalence of thiamine deficiency is significant in patients undergoing primary bariatric surgery

Albaugh, Vance L.; Williams, D. Brandon; Aher, Chetan V.; Spann, Matthew D.; English, Wayne J.

doi:10.1016/j.soard.2020.11.032

Cited by 11 publications

(10 citation statements)

References 21 publications

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“…Only one patient at 1 year following surgery exhibited thiamin abnormality and was clinically symptomatic. These findings are similar to those of Albaugh et al who found a 3.5% thiamin deficiency in a cohort of 346 patients 37 . However, it is in contrast with others, who have reported a much higher prevalence of thiamin deficiency of up to 29% 6,32,38 .…”

Section: Discussionsupporting

confidence: 91%

“…These findings are similar to those of Albaugh et al who found a 3.5% thiamin deficiency in a cohort of 346 patients. 37 However, it is in contrast with others, who have reported a much higher prevalence of thiamin deficiency of up to 29%. 6,32,38 This difference may be attributed to race with Caucasians experiencing less thiamin deficiency than African Americans or Hispanics.…”

Section: Discussionmentioning

confidence: 75%

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Investigating the prevalence of nutritional abnormalities in patients prior to and following bariatric surgery

Zarshenas

Tapsell

Batterham

et al. 2022

Nutrition & Dietetics

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Aims: Bariatric surgery remains an effective treatment for the condition of obesity. However it predisposes patients to nutritional deficiencies and related complications. The aim of this study was to identify nutritional abnormalities, weight loss, adherence to supplements, and presence of gastrointestinal symptoms in a cohort of bariatric surgical patients.Methods: An analysis of the electronic medical records of patients attending a multidisciplinary private clinic in Sydney, Australia from August 2020 to August 2021 was conducted. Data on anthropometric measures, nutritional indices, adherence to supplements and gastrointestinal symptoms preoperatively and then at ≤6 months, 1 and 2 years or more postoperatively were collected.Results: A total of 231 patients were included in the study. The majority of patients were female (76.2%), with a sleeve gastrectomy (78.8%). Average preoperative BMI was 43.4 ± 7.1 kg/m 2 . Weight loss ≥2 years postsurgery was 33.5 ± 12.4 kg. The most common abnormalities preoperatively were: C-reactive protein (47.7%), vitamin D (39%), B 12 (31%), parathyroid hormone (27.6%) and ferritin (12.7%). Vitamin B 12 (23.2%), parathyroid hormone (23%), vitamin D (17.7%) and ferritin (15.9%) remained common abnormalities postoperatively. Adherence to multivitamins was 90% in the first year following surgery, declining to 77% at ≥2 years. Gastrointestinal symptoms were predominantly present in the initial stages following surgery, manifesting thiamin deficiency in 6.5% of patients.Conclusions: Despite achieving durable weight loss, nutritional and related abnormalities remain an ongoing challenge for bariatric surgery. Adherence to nutrient supplements, gastrointestinal symptoms and related complications are important considerations in addressing the problem.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 75%

Investigating the prevalence of nutritional abnormalities in patients prior to and following bariatric surgery

Zarshenas

Tapsell

Batterham

et al. 2022

Nutrition & Dietetics

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“…Overall, while 35 patients (10%) were with thiamine deficiency with concentrations <70nM . On the average, these patients were of similar age and were all undergoing primary procedures (50% Roux-En-y gastric bypass, 50% sleeve gastrectomy) [5].…”

Section: Comparing the Results With Other Studies' Results For Other ...mentioning

confidence: 99%

Incidence of Vitamin B1 (Thiamine) Deficiency Post Mini-Gastric Bypass: A Prospective Study

IBRAHEM¹,

ELSAYED

2022

The Medical Journal of Cairo University

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Background: Laparoscopic Mini-Gastric Bypass is considered as a restrictive & mal-absorptive technique with excision of most of the stomach plus bypassing about 2 meters of small intestine including (duodenum and jejunum). The main complication is the Vitamins and micronutrients deficiency as Thiamine (vit. B1). These deficiencies caused by many causes as mal-absorption withMini Gastric Bypassdue to bypassing the site of thiamine absorption. Aim of Study:The study aims to determine the impact of Mini-Gastric Bypass on thiamine (vit. B1) absorption and deficiency.Patients and Methods: A Prospective study was included 15 patients presented for Mini-Gastric Bypass Surgery At Ain Shams Hospitals and Kafr El Sheikh General Hospital from October 2020 to October 2021. Clinical history was obtained that included demographic data, history of pre-operative vitamin deficiency and comorbid diseases.Diagnosis of Thiamine deficiency was by measuring thiamine at 3 and 6 months postoperative. All patients had performed Mini-Gastric Bypass operation with intraoperative parameters: Bilio-Pancreatic limb of 2 meters is bypassed. Patients postoperatively were ensured for daily supplement of oral thiamine. Results:The mean age of the studied group was 35 years. (55%) of them were females and (45%) males. The mean BMI was 40 kg/M2 .No one of the study cases had thiamine deficiency preoperative, all showed normal total thiamine level (3.2-9.5ug/dl).The results postoperative show 100% of cases show deficiency in total thiamine level 3 & 6 months postoperative.The Mean Excess Weight Loss percentage (EWL%) shows increase in loss about 36%, 56%, 3 & 6 months postoperatively respectively. Conclusion:Mini-Gastric Bypass is an effective operation in losing weight in the first postoperative months, despite of that is corresponding early significant deficiency of thiamine (Vit. B 1), one of the most important vitamins for energy and neurological integrity.

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“…[12][13][14] Importantly, the level of thiamine is also noted to be low in obese individuals with intention to have bariatric surgery. 15,16 Therefore, it is plausible to suggest that in our patient different factors have contributed to the need for thiamine replacement; among them are diabetes, obesity, and bariatric surgery. Ultimately, this may have resulted in persistent high plasma ketones level since she had the bariatric surgery.…”

Section: Discussionmentioning

confidence: 96%

Recurrent Diabetic Ketoacidosis following Bariatric Surgery: The Role of Micronutrients

2021

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We report a case of a 29-year-old woman admitted twice to our hospital with diabetic ketoacidosis (DKA) within 45 days following her bariatric surgery. The first admission required intensive care during her postoperative days after bariatric surgery. Subsequently, she continued to report high level of ketones on a daily basis. At her second admission, she presented with all three criteria of DKA. She was treated with a standard protocol for DKA, but ketones plasma level remained high despite significant improvement in pH and glycemic control. The administration of thiamine replacement was associated with normalization of the hyperketonemia. Thiamine deficiency can be associated with bariatric surgery and can lead to high ketone level in individuals with type 1 diabetes.

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Prevalence of thiamine deficiency is significant in patients undergoing primary bariatric surgery

Cited by 11 publications

References 21 publications

Investigating the prevalence of nutritional abnormalities in patients prior to and following bariatric surgery

Investigating the prevalence of nutritional abnormalities in patients prior to and following bariatric surgery

Incidence of Vitamin B1 (Thiamine) Deficiency Post Mini-Gastric Bypass: A Prospective Study

Recurrent Diabetic Ketoacidosis following Bariatric Surgery: The Role of Micronutrients

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