Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis

Chung, Cecilia P.; Oeser, Annette; Solus, Joseph F.; Avalos, Ingrid; Gebretsadik, Tebeb; Shintani, Ayumi; Raggi, Paolo; Sokka, Tuulikki; Pincus, Theodore; Stein, C. Michael

doi:10.1016/j.atherosclerosis.2007.01.004

Cited by 294 publications

(269 citation statements)

References 37 publications

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“…In India, also higher prevalence of MS has been reported from Silchar (39.28% in RA and 20 % in controls) and Chandigarh (31.57%in RA and 14.9%). 19,[21][22][23][24][25][26][27] When exploring the clinical and biochemical parameters in present study, RA patients had lower HDL, higher systolic BP and higher diastolic BP compared with healthy controls, a difference that was statistically significant. These results are in accordance with observations made by Rostom et al and Pandey et al 16,26 We did not find any significant correlation of body mass index (BMI), waist circumference and sugar between two groups.…”

Section: Discussionmentioning

confidence: 90%

“…These are in accordance with previous studies but we didn`t find any correlation of remaining two components of metabolic syndrome (abnormal waist circumference and elevated TG`s) with increased prevalence of MS in RA as in these studies. 16,25 The negative correlation of abnormal waist circumference with MS in our RA patients as discussed earlier can be linked to proposed hypothesis of poor nutrition. However, TG`s not having significant correlation with MS in RA patients in present study can be better explained by the fact that the lipid profile of RA patients has been evaluated in several studies that have reported dyslipidemia as well as normal pattern in RA patients when compared to controls.…”

Section: Discussionmentioning

confidence: 95%

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Prevalence and predictors of metabolic syndrome in rheumatoid arthritis

et al. 2017

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Background: Rheumatoid arthritis (RA) is associated with increased cardiovascular morbidity and mortality secondary to accelerated atherosclerosis. There is a strong association of metabolic syndrome (MS) with atherosclerosis. The objective of this study was to assess the prevalence of MS in RA and to identify the predictors of MS in RA. Methods: The study included 100 patients of RA (83 females,17 males; median age 42.5(17) years diagnosed according to 2010 American College of Rheumatology-European League Against Rheumatism classification criteria who were on treatment and 110 age and sex-matched apparently healthy controls (26 males, 84 females; median age 45 (20) years). The frequency of MS was assessed using joint consensus 2009 criteria. Patients were also assessed in terms of disease activity, using disease activity score 28 CRP. Logistic regression was used to identify predictors of MS in RA.Results: Metabolic syndrome was found in 45% of RA group and 22.7% of control group according to joint consensus 2009 criteria (p<0.005). RA group was significantly more likely to have low high-density lipoprotein (65%), elevated blood pressure (60%) levels and abnormal sugar (28%). In RA group, CRP (odds ratio: 1.101, confidence interval: 1.032-1.174 (p=0.004) {adjusted for age, DAS 28 score & Anti-CCP} remained independent predictor for presence of MS in RA.Conclusions: The frequency of MS was higher in RA group compared to control group. High CRP remained independent predictor associated with presence of MS. There was no association of high disease activity with MS in our RA patients. These findings suggest that the treating physician should screen RA patients early for presence of MS.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 95%

Prevalence and predictors of metabolic syndrome in rheumatoid arthritis

et al. 2017

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“…For example, in obesity and metabolic syndrome, host immune responses are also predisposed to a Th1-dominant profile via IL-12 and leptin (59 -61). Recent studies indicate strong clinical associations between metabolic syndrome and periodontitis (33,34), as well as chronic inflammatory diseases such as arthritis (62), atherosclerosis (63), and diabetes (64). These clinical associations may also be dependent upon the IL-12-mediated Th1 pathway.…”

Section: Discussionmentioning

confidence: 99%

T Cell Response Mediated by Myeloid Cell-Derived IL-12 Is Responsible for Porphyromonas gingivalis-Induced Periodontitis in IL-10-Deficient Mice

Sasaki¹,

Suzuki

Kent

et al. 2008

The Journal of Immunology

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Periodontal disease is a chronic inflammatory disease in the oral cavity, which culminates in alveolar bone loss. Porphyromonas gingivalis is a consensus periodontal pathogen that has been implicated in adult forms of periodontitis. We previously demonstrated that IL-10-deficient mice exhibit a hyperinflammatory phenotype and are highly susceptible to P. gingivalis-induced periodontitis, indicating an important anti-inflammatory effect of IL-10 in suppressing bone loss. In this study, we analyzed the pathway(s) by which IL-10 deficiency leads to severe P. gingivalis-induced periodontitis. Because Stat3 is essential in IL-10 signaling, immune cell-specific Stat3-deficient mice were subjected to P. gingivalis infection to identify the key IL-10-responsive cells in preventing periodontitis. Myeloid cell-specific Stat3-deficient mice exhibited increased periodontal bone loss (p < 0.001), whereas T cell- and B cell-specific Stat3 mice were resistant, suggesting that macrophages (MP) and/or polymorphonuclear leukocytes are the key target cells normally suppressed by IL-10. Myeloid cell-specific Stat3-deficient mice exhibited elevated gingival CD40L gene expression in vivo compared with wild-type controls (p < 0.01), and Stat3-deficient MPs exhibited vigorous P. gingivalis-stimulated IL-12 production in vitro and induced elevated Ag-specific T cell proliferation compared with wild-type MPs (p < 0.01). Of importance, both IL-12p40/IL-10 and T cell/IL-10 double-deficient mice were resistant to P. gingivalis-induced periodontitis, demonstrating roles for both IL-12p40 and T cells in pathogenesis in a hyperinflammatory model of disease. These data demonstrate that P. gingivalis-induced periodontitis in IL-10-deficient mice is dependent upon IL-12p40-mediated proinflammatory T cell responses.

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“…Many genetic links have been established for the comorbidity of CVD and RA such as histocompatibility complex [41], human leukocyte antigen DRB1 genotype [42], the IL-6-174C allele [43] and the TNF-α-1031 T/C polymorphism [44].…”

Section: Genetic Associationmentioning

confidence: 99%

Co-Morbidity of Cardiovascular Diseases and Rheumatoid Arthritis

Pandya

et al. 2017

Asian J Pharm Clin Res

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Rheumatoid arthritis (RA) is a chronic disease related to swelling of joints which lead to restriction in movement due to pain and deformity mainly in feet, ankle, wrist, and fingers. It is an autoimmune disease, and the manifestations caused due to its occurrence are not clearly understood. In today's time, it has been observed that comorbid conditions account for most of the deaths as they influence the outcome of RA and limit therapeutic options. The most common comorbid conditions which are diagnosed in RA patients are generally cardiovascular (CV) abnormalities, several infections, certain mental disorders, and malignancies. Among which CV comorbid diseases are the most common kind relating to disorders of heart and blood vessel that eventually leads to severe conditions such as angina, myocardial infarction, stroke, rheumatic heart disease, and many more. RA affects the quality of life of patients directly or indirectly, but it mainly shows a significant increase in the prevalence of CV diseases. Hence, it is essential to diagnose and understand about the related manifestations when one is suffering from RA. These studies will aid to make better treatment and management strategies. Hence, an attempt has been made in this review article regarding the epidemiology, impact of both diseases and related risk factors. It also gives information in brief about the pathological causes of the comorbidity and summarizes measures that may be used in the prevention and treatment of these conditions.

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Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis

Cited by 294 publications

References 37 publications

Prevalence and predictors of metabolic syndrome in rheumatoid arthritis

Prevalence and predictors of metabolic syndrome in rheumatoid arthritis

T Cell Response Mediated by Myeloid Cell-Derived IL-12 Is Responsible for Porphyromonas gingivalis-Induced Periodontitis in IL-10-Deficient Mice

Co-Morbidity of Cardiovascular Diseases and Rheumatoid Arthritis

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