2006
DOI: 10.1590/s0004-28032006000300013
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: -Background -Nonalcoholic steatohepatitis is a chronic liver disease with a high prevalence in the general population and a potential to evolve into cirrhosis. It is speculated that iron overload could be associated with liver injury and unfavorable progress in affected patients. Aims -To evaluate the prevalence of mutation of the hemochromatosis gene (HFE) in patients with nonalcoholic steatohepatitis and to correlate it with histological fi ndings in liver specimens. Patients and Methods -Twenty-nine patient… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
20
0
1

Year Published

2011
2011
2013
2013

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 14 publications
(66 citation statements)
references
References 36 publications
(66 reference statements)
1
20
0
1
Order By: Relevance
“…Corroborating our results, the study by Zamin et al did not establish correlation between mutation of the C282Y and H63D gene (mutation involved in the genesis of hemochromatosis), in 20 patients with NASH. This reinforces the nonparticipation of Fe deposits in the physiopathology of NASH (23) .…”
Section: Discussionsupporting
confidence: 72%
“…We excluded 153 studies due to lack of data on the HFE genotypes in NAFLD participants; whose liver disease was not defined as NAFLD; or whose participants were reported included in separate reports. A total of 16 case-control studies [20, 21, 3549] (Table 1) and 14 ‘case-only’ studies [5063] (Table 2), or 2,610 cases and 7,298 controls were included for the current review.…”
Section: Resultsmentioning
confidence: 99%
“…Overall, twenty-two studies were originated in Europe, North America, or Australia [20, 21, 35, 3740, 42–45, 47, 48, 50, 51, 5460, 63], two studies in Brazil [49, 52] and Japan [61, 62], respectively and, one study each in Korea [36], Taiwan [41], India[53] and Turkey [46]. The quality of the reporting varied across the papers.…”
Section: Resultsmentioning
confidence: 99%
“…It is likely that similar differences (in either lipidomic profiles or dietary fat composition) may influence effects of iron overload in humans, and may partly explain the somewhat mixed results of clinical studies. Hemochromatosis gene mutations have been either associated with increased severity [14,15,35,36] or found to be unrelated [37,38] to NASH. Stainable liver iron or serum transferrin were associated with NASH severity in some [16,35,39] but not all [37,40,41] studies.…”
Section: Discussionmentioning
confidence: 99%
“…However, subsequent studies in NAFLD subjects assessing the presence of stainable hepatic iron deposits, HIC or both, yielded conflicting results, with some studies finding hepatic iron to be associated with more advanced NASH [3][4][5] and others not finding such an association [6][7][8][9][10]. It is important to note that these early studies had several limitations including small sample size, lack of uniform criteria for the diagnosis of NASH and lack of a standardized liver histologic scoring system for stage or grade of liver disease and iron deposition.…”
Section: Introductionmentioning
confidence: 99%