Prevalence of symptoms, sensitization to rats, and airborne exposure to major rat allergen (Rat n 1) and to endotoxin in rat‐exposed workers: a cross‐sectional study

Lieutier‐Colas, F.; Meyer, P.; Pons, Ferrán; Hédelin, Guy; Larsson, Peter; Malmberg, Per; Pauli, G.; Blay, F. De

doi:10.1046/j.1365-2745.2002.01502.x

Cited by 34 publications

(25 citation statements)

References 24 publications

(39 reference statements)

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“…Other nonallergenic pollutants, such as endotoxins, may be responsible for WRNS in subjects with negative SPT to LA, even though the relation between endotoxin levels and WRNS was not confirmed in workers exposed to rats (21). Moreover, some SPT-negative symptomatic worker may have local immunoglobulin E production to LA allergens in the nasal mucosa, may have been tested with a low quality LA extract or may have been sensitized to another allergen in the workplace that was not tested in SPT (21).…”

Section: Discussionmentioning

confidence: 93%

“…Prevalence rates were reported by the authors in six studies (15,(18)(19)(20)(21)(22). We calculated prevalence rates in the others (8-14, 16, 17) as the percentage of cases of OA or OR divided by the number of subjects in each study (Table 1).…”

Section: Prevalence Ratesmentioning

confidence: 99%

“…Between 1980 and 2004, 15 prevalence reports studied OA and OR in workers exposed to LA (Table 1) (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). The participation rate ranged from 61% to 100%, median 77-78%.…”

Section: Cross-sectional Studiesmentioning

confidence: 99%

“…In one study exposure to which LA was not specified, but they were small mammals used in a pharmaceutical company (9). Exposure to one animal only was found in six studies: to a rat in four (17)(18)(19)21) and a mouse in two (Table 1) (11,18). Positive SPT to common aeroallergens, performed in 12 studies, ranged from 15.6% to 60.0%, median 40%.…”

Section: Cross-sectional Studiesmentioning

confidence: 99%

“…To investigate trends in the prevalence and incidence of OA and OR over time, we reviewed the available published literature for both (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27).…”

mentioning

confidence: 99%

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Have the prevalence and incidence of occupational asthma and rhinitis because of laboratory animals declined in the last 25 years?

Folletti¹,

Forcina²,

Marabini

et al. 2008

Allergy

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Background: Data for time trends in the prevalence of occupational asthma (OA) and rhinitis (OR) are not known.Objective: To investigate the prevalence and incidence of OA and OR over time.Methods: We chose to review studies on the prevalence and incidence of OA and OR due to laboratory animals (LA) as a marker of changing OA and OR patterns over time and analysed 15 cross‐sectional and 4 longitudinal studies published from 1980 to 2006.Results: The estimated prevalence of OA, defined as work‐related chest symptoms (WRCS), declined from 8.2% in 1976 to 4.2% in 2001 (P < 0.005). When defined by WRCS and positive skin prick test (SPT) to LA, the estimated prevalence of OA was 6.7% in 1977 and 2.9% in 1999 (P < 0.02). The prevalence of OR, defined by WRNS or WRNS and SPT to LA, was not related to study date but was inversely associated with mean exposure duration. In four longitudinal studies no clear trend emerged over time.Conclusions: This review suggests a trend toward a progressive decline in the prevalence of occupational asthma due to laboratory animals, which may be due to the reduction of exposure since the early 1980s. A further reduction of exposure is needed to prevent the onset of occupational rhinitis.

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Section: Discussionmentioning

confidence: 93%