Prevalence of substance misuse in first-episode psychosis

Cantwell, Roch; Brewin, J.; Glazebrook, Cris; Dalkin, T.; Fox, Richard; Medley, Ian; Harrison, Glynn

doi:10.1192/bjp.174.2.150

Cited by 206 publications

(157 citation statements)

References 17 publications

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“…The finding in this study of a prevalence of 45.3% of DD is within the range found by some authors (Cantwell et al, 1999;Margolese et al, 2004), although it should be not- ed that other studies report lower prevalences. For example, Brady et al (1991) found that 29 out of 100 patients admited to a psychiatric unit for acute cases met the DSM-III-R criteria for SUD in the 30 days prior to their admission.…”

Section: Discussionsupporting

confidence: 69%

Sociodemographic and clinical factors associated with dual disorders in a psychiatric hospital

Pérez

Bernal

Silva

et al. 2017

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Introduction. Among patients with mental illness, dual disorders patients are characterized by a heterogeneous and more severe clinical presentation that is difficult to treat. Therefore, knowledge about the distribution of this disorder and the characteristics of these patients can be helpful to optimize and organize health resources. Objective. To explore the prevalence and socio-demographic and clinical factors associated with dual disorders patients who were hospitalized due to mental illness at a psychiatric unit in Colombia between January and June 2013; this data was collected and analyzed on the basis of the medical records of each patient. Method. Observational, quantitative, cross-sectional study of a secondary source. It included the analysis of 201 patients aged 18 to 65. Results. There were 201 patients analyzed; 45.3% had dual disorders, with a ratio of 2.24 men:women; there was a high frequency of single marital status (69.2%) and more than 90% had a low socioeconomic level. The factors significantly associated with dual disorders in order of importance were: age from 18 to 35 years (OR = 11.03; CI 95% [4.43, 27.46]), male (OR = 5.10, CI 95% [2.26, 11.50]), history of aggression (OR = 3.35; CI 95% [1. 63, 6.91]), and readmission in the year after hospital discharge (OR = 2.23; CI 95% [1.08, 4.61]). Discussion and conclusion. Dual disorders prevalence in this study is similar to that found by other authors. The high prevalence of dual disorders requires specialized therapeutic programs for treatment. The more hospitals know about the associated variables in this study, the more they will be able to improve their approach to patients.

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Section: Discussionsupporting

confidence: 69%

Sociodemographic and clinical factors associated with dual disorders in a psychiatric hospital

Pérez

Bernal

Silva

et al. 2017

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“…Nevertheless, this study suggests the need for greater attention to the prevalence, impact, and treatment of SUDs in HD. Given the similarity of these findings to studies on primary psychiatric syndromes where SUDs seem particularly associated with male gender, greater psychiatric morbidity, and earlier age of illness onset (Cantwell et al, 1999;Dixon, 1999;RachBeisel et al, 1999;Siegfried, 1998), further research on HD as a dual diagnosis condition with relatively well-defined genetic and neurobiological origins is warranted. Table 1 Demographics ( (36) 111 (62) 235 (58) 275 (71) Female 645 (64) 69 (38) 172 (42) 110 (29) Marital status Married 773 (77) 124 (69) 288 (71) 251 (65) Separated/divorced…”

Section: Discussionmentioning

confidence: 99%

Huntington disease as a dual diagnosis disorder: Data from the national research roster for Huntington disease patients and families

Ehret

Day

Wiegand

et al. 2007

Drug and Alcohol Dependence

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Although an extensive literature characterizes a linkage between primary mental illnesses and substance use disorders, a paucity of research exists concerning dual diagnosis phenomena in Huntington disease (HD). Data from the National Research Roster on HD suggest that higher levels of alcohol and cigarette use are associated with greater ratings of psychiatric symptoms and a younger age of HD symptom onset, and that progressive alcohol use after HD symptom onset is linked with worsening psychiatric symptom progression. These findings suggest HD entails dual diagnosis phenomena similar to that identified in patients with primary psychiatric disorders.

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“…(Cantwell et al, 1999;Veen et al, 2004;Henquet et al, 2005;Mauri et al, 2006;Koskinen et al, 2010;Mazzoncini et al, 2010;Barrigón et al, 2010). Several studies on schizophrenia have reported that patients with SUD have worse premorbid social functioning (Sevy et al, 2010;Mazzoncini et al, 2010;Compton et al, 2011;Schimmelmann et al, 2011), more severe symptoms at onset (Gearon and Bellack, 2000;Dawe et al, 2011), lower compliance and worse treatment response, thus more inappropriate use of mental health services, (Lambert et al, 2005;de Haan et al, 2007;Schimmelmann et al, 2011) with higher mental health costs (Bartels et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Does substance use disorder affect clinical expression in first-hospitalization patients with schizophrenia? Analysis of a prospective cohort

Picci

Versino

Oliva

et al. 2013

Psychiatry Research

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Introduction. Although several papers reported a wide range of negative outcomes among patients with both schizophrenia and SUD, only a few studies evaluated the impact of SUD on psychopathology and thus on the length of first-hospitalization. Objectives.To compare clinical expression of first-episode of schizophrenia between inpatients with and without SUD, giving close attention to the length of stay.Methods. 130 inpatients at first-episode of schizophrenia were assigned to SUD or not SUD group depending on SUD diagnosis and were assessed through BPRS at admission, during hospitalization and at discharge. Cross-sectional and longitudinal statistical analysis were performed to investigate differences between groups and also a linear regression was used to evaluate relationship between length of stay and BPRS scores.Results. During the hospitalization there was a more marked improvement of BPRS total score in patients without SUD with a lower length of hospitalization (P<0.001). BPRS score during hospitalization was predictor of higher length of stay.Discussion. The higher severity of psychopathology during the hospitalization suggest possible overlaps of substance induced and withdrawal symptoms. Conversely, higher levels of conceptual disorganization during the whole period of hospitalization also support a more severe and pharmacho-resistant expression of schizophrenia among SUD patients.

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Prevalence of substance misuse in first-episode psychosis

Abstract: This study confirms high rates of substance misuse at onset of psychosis. There is evidence for an increase in diagnosis of substance-related psychotic disorders over time. Those most at risk of substance misuse are young males.

Cited by 206 publications

References 17 publications

Sociodemographic and clinical factors associated with dual disorders in a psychiatric hospital

Sociodemographic and clinical factors associated with dual disorders in a psychiatric hospital

Huntington disease as a dual diagnosis disorder: Data from the national research roster for Huntington disease patients and families

Does substance use disorder affect clinical expression in first-hospitalization patients with schizophrenia? Analysis of a prospective cohort

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