International Journal of Occupational Medicine and EnvironmentalThe study results show that a relatively high proportion of workers (20.7%) belongs to the high-strain group based on Karasek's model. The prevalence of work-related depression among workers was relatively high (18.8%). The factors associated with depression at work were high psychological demand (adjusted OR = 3.0, 95% CI: 1.1-8.3), low social support (adjusted OR = 4.7, 95% CI: 1.2-12.8), inadequate work protection materials (OR = 4.1, 95% CI: 2.2-10.1) and work absenteeism (OR = 6.2, 95% CI: 2.5-18.9). Conclusions: Strengthening the social support network (involving supervisors and co-workers), reducing psychological job demand and assuring work protection materials at the workplace may highly facilitate reducing work-related depression.