Prevalence of Staphylococcus aureus carrying Panton—Valentine leukocidin genes among isolates from hospitalised patients in China

Yu, Fangyou; Chen, Z.; Liu, C.; Zhang, X.; Lin, Xiaohui; Chi, Shengying; Zhou, Tieli; Chen, X.

doi:10.1111/j.1469-0691.2007.01927.x

Cited by 139 publications

(122 citation statements)

References 19 publications

(30 reference statements)

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“…Apparently, some communityacquired MRSA types (e.g., ST30, ST80, ST152) are PVL positive in most cases, whereas others (e.g., ST398) are not. However, although all the MRSA ST398 isolates found in Europe to date were PVL negative, a PVL-positive MRSA ST398 strain was recently detected in China (13).…”

Section: The Studymentioning

confidence: 98%

Methicillin-ResistantStaphylococcus aureusST398 from Human Patients, Upper Austria

Krziwanek¹,

Metz-Gercek²,

Mittermayer³

2009

Emerg. Infect. Dis.

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Section: The Studymentioning

confidence: 98%

Methicillin-ResistantStaphylococcus aureusST398 from Human Patients, Upper Austria

Krziwanek¹,

Metz-Gercek²,

Mittermayer³

2009

Emerg. Infect. Dis.

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“…The prevalence of PVL-positive S. aureus was 2.3% in Chinese hospitals, but 12.8% in Wenzhou, China Yu et al, 2008). The prevalence of PVL-positive strains of S. aureus in Japan, Africa and the USA was 0.04, 14.7 and 48.3% (Kawaguchiya et al, 2011;Mesrati et al, 2010;Lowy et al, 2007), respectively.…”

Section: Mlst-ccmentioning

confidence: 93%

Molecular characteristic of Staphylococcus aureus isolates in a Chinese teaching hospital

Ma¹,

Chen²,

Zhou³

et al. 2011

Afr. J. Microbiol. Res.

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The aim of this study is to investigate the genetic backgrounds of methicillin susceptible Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA) and heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) isolates isolated from clinical specimens of the patients with verified infections in a Chinese teaching hospital. Macro E test (MET) was used to detect hVISA and multilocus sequence typing (MLST) was used to determine the STs of the selected isolates. The genotypes of SCCmec were determined by multiplex polymerase chain reaction (PCR) in MRSA isolates. Panton-valentine leucocidin (PVL) genes were also detected by PCR. Among 273 S. aureus isolates, hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA), community-associated methicillin-resistant S. aureus (CA-MRSA), hospital-acquired methicillin susceptible Staphylococcus aureus (HA-MSSA) and community-associated methicillin susceptible Staphylococcus aureus (CA-MSSA) isolates accounted for 55.6, 1.5, 36.3, and 6.6%, respectively. Nine isolates were confirmed as hVISA by MET. Among 60 HA-MRSA isolates, ST239-MRSA-III was the most prevalent clone accounting for 51.7%, followed by ST5-MRSA-II clone. Fifty percentage and 22.2% of CA-MSSA isolates were found to be ST121 and ST88. ST239-MRSA-III was the predominant clone in hVISA isolates. However, no predominant ST type was found in HA-MSSA isolates. Of 9 PVL-positive strains, ST88 was the most prevalent ST (50.0%; 4/8), followed by ST121 (33.3%; 3/9), ST5 (4.5%; 1/22) and ST239 (2.6%; 1/39). In conclusion, ST239-III was the major pandemic clone in hVISA and HA-MRSA and spread in China. ST5-emerging rapidly in China had remained stable viability.

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“…It is capable of acquiring virulence genes, and its acquisition of the PantonValentine leukocidin (PVL) gene (pvl) has been demonstrated [37,61,62]. Regarding other virulence factors, staphylococcal enterotoxins occasionally have been reported in LA-MRSA CC398 in pigs [53,[63][64][65] and turkeys [33••].…”

Section: Cc398mentioning

confidence: 99%

Livestock-Associated MRSA and Its Current Evolution

Butaye

Argudín

Smith

2016

Curr Clin Micro Rpt

106

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Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is a relatively recent phenomenon in veterinary medicine. Although in the beginning it was restricted to a single clonal complex (CC), CC398, it has expanded into several clonal complexes, and the diversity of subtypes in the clonal complexes is increasing also. The prevalence of each type is determined somewhat geographically; for instance, the most prevalent clonal complex in Europe is CC398, whereas in Asia, it is CC9. Although few data exist regarding North America, the situation appears to be mixed there. The SCCmec cassettes detected in LA-MRSA are limited mainly to SCCmec IVa and SCCmec V, although non-typeable cassettes and SCCmec type XI, containing mecC, also have been found.The source of the SCCmec in LA-MRSA was discovered to be animals. In searching from which bacteria the SCCmec cassettes in LA-MRSA have been transferred, the most obvious species to consider are the methicillin-resistant non-S. aureus staphylococci (MRNaS). However, very few data are available from those species in animals, and the data that do exist are not detailed enough to determine the origin. Nevertheless, similar cassettes were found in MRNaS, indicating a possible origin that needs to be investigated further.

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Prevalence of Staphylococcus aureus carrying Panton—Valentine leukocidin genes among isolates from hospitalised patients in China

Cited by 139 publications

References 19 publications

Methicillin-ResistantStaphylococcus aureusST398 from Human Patients, Upper Austria

Methicillin-ResistantStaphylococcus aureusST398 from Human Patients, Upper Austria

Molecular characteristic of Staphylococcus aureus isolates in a Chinese teaching hospital

Livestock-Associated MRSA and Its Current Evolution

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