Prevalence of Soy Protein Hypersensitivity in Cow's Milk Protein-Sensitive Children in Korea

Abstract

This study was aimed to evaluate the prevalence of soy protein hypersensitivity in cow's milk protein-sensitive children in Korea. A total of 1,363 patients with atopic dermatitis, urticaria, enterocolitis syndrome, bronchial asthma or allergic rhinitis were recruited. First, we estimated the prevalence of sensitization to soy in children sensitized to cow's milk. Specific IgE levels > 0.7 kU/L by CAP assay were considered positive. Next, the prevalence of soy allergy in cow's milk allergy (CMA) patients was investigated. Those children whose parents agreed to participate the open challenge test with soy had a convincing history of allergic reactions elicited by cow's milk and these symptoms were relieved by elimination. All of them had negative soy-specific IgE. Patients with positive soy-specific IgE accounted for 18.3% of 224 children sensitized to cow's milk protein. The prevalence of sensitization to soy decreased with age (36.8% in the first year of life, 16.4% in the second year, and 13.7% in the third year). Of 21 CMA patients, 42.9% (n=9) were determined to have soy allergy (mean age 10.3 months). Our results suggest that soy protein formula should be carefully used as a substitute for cow's milk in CMA patients, especially during infancy.

Development of a H2O2‐sensitive quantum dots‐based fluorescent sandwich ELISA for sensitive detection of bovine β‐lactoglobulin by monoclonal antibody

“…Actually, a previous study also showed BLG has a weak cross‐reactivity with CNs . In addition, both cows' milk protein‐sensitised mice and cows' milk allergy patients shown that milk proteins had cross reactivity to soy protein . However, no cross‐reactivity existed between BLG and soy protein (Fig.…”

“…36 In addition, both cows' milk protein-sensitised mice and cows' milk allergy patients shown that milk proteins had cross reactivity to soy protein. 37,38 However, no cross-reactivity existed between BLG and soy protein (Fig. 4C), indicating that the developed immunoassay was highly specific.…”

Allergenic Proteins in Soybean: Processing and Reduction of P34 Allergenicity

“…2,75,76 Soy formulas are often indicated when an infant is allergic to cow's milk; however, there is evidence that 8% to 14% of infants with cow's milk allergy are also reactive to soy formulas. 77,78 Ahn et al 79 studied the prevalence of soy protein hypersensitivity in children with cow's milk allergy; 18.3% of 224 children were found to have positive soy-specific IgE. Hydrolyzed formulas may be potentially useful for preventing allergic symptoms, but further studies are needed to evaluate this possibility.…”

Immunogenicity and allergenicity of 2S, 7S and 11S soy protein fractions

“…The prevalence of a concomitant intolerance to soy in the allergy to cow milk is between 0% and 63% with high levels in the enterocolitis/enteropathy syndromes not associated with IgE (Van Sickle et al, 1985;Bock, Atkins, 1990;Ragno et al, 1993;Burks et al, 1994;Harikul et al, 1995). However, the true prevalence of allergy to soy proteins in documented allergies to proteins in cow milk is not yet well established (Kuitunen et al, 1975;Jakobsson, Lindberg, 1979;Zeiger et al, 1999;Ahn et al, 2003).…”